(Q28271011)

2

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Makoto Goto

3

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Yasuhiro Furuichi

4

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Masanobu Sugimoto

Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer

5

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language of work or name

English

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publication date

May 2008

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published in

Cancer Science

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volume

99

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issue

5

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page(s)

843-8

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cites work

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2008.00778.X

Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases

21 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2008.00778.X

A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity

21 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2008.00778.X

Nucleolar localization of the Werner syndrome protein in human cells

21 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2008.00778.X

Functional and physical interaction between WRN helicase and human replication protein A

21 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2008.00778.X

Mammalian telomeres end in a large duplex loop

21 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2008.00778.X

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

21 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2008.00778.X

Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution

21 April 2017

1 reference

https://api.crossref.org/works/10.1111/J.1349-7006.2008.00778.X

Positional cloning of the Werner's syndrome gene

21 April 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

Cancer. Addiction to oncogenes--the Achilles heal of cancer

21 April 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

Molecular biology of Werner syndrome

21 April 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

Differential effects of cytotoxic drugs on mortal and immortalized B-lymphoblastoid cell lines from normal and Werner's syndrome patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

Telomerase, Cell Immortality, and Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

Steps involved in immortalization and tumorigenesis in human B-lymphoblastoid cell lines transformed by Epstein-Barr virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

Reconsideration of senescence, immortalization and telomere maintenance of Epstein-Barr virus-transformed human B-lymphoblastoid cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

WRN gene and other genetic factors affecting immortalization of human B-lymphoblastoid cell lines transformed by Epstein-Barr virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

In vitro establishment of tumorigenic human B-lymphoblastoid cell lines transformed by Epstein-Barr virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

A critical role for telomeres in suppressing and facilitating carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

Abnormal telomere dynamics of B-lymphoblastoid cell strains from Werner's syndrome patients transformed by Epstein-Barr virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

Telomeres, stem cells, senescence, and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

Telomeres, crisis and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

Differential regulation of human RecQ family helicases in cell transformation and cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

Differential cytotoxicity of anticancer agents in pre- and post-immortal lymphoblastoid cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

Effects of topoisomerase II inhibition in lymphoblasts from patients with progeroid and "chromosome instability" syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

Telomeres do D-loop-T-loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

Functional interaction between Ku and the werner syndrome protein in DNA end processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

DNA damage-induced translocation of the Werner helicase is regulated by acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X

A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1349-7006.2008.00778.X