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The human Mediator complex: a versatile, genome-wide regulator of transcription
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title
The human Mediator complex: a versatile, genome-wide regulator of transcription
(English)
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author name string
Dylan J Taatjes
series ordinal
1
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language of work or name
English
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publication date
June 2010
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published in
Trends in Biochemical Sciences
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volume
35
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issue
6
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page(s)
315-22
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cites work
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Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation
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MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription
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20 March 2017
PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator
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Principal role of TRAP/mediator and SWI/SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation
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SOX9 interacts with a component of the human thyroid hormone receptor-associated protein complex
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TFIID and human mediator coactivator complexes assemble cooperatively on promoter DNA
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20 March 2017
TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4.
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Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s
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TFIIH is negatively regulated by cdk8-containing mediator complexes
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Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation
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Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3
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Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein
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Composite co-activator ARC mediates chromatin-directed transcriptional activation
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Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
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Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex
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A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II.
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Divergent transcription from active promoters
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RNA polymerase is poised for activation across the genome
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Transcription regulation and animal diversity
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CDK8 is a positive regulator of transcriptional elongation within the serum response network
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Dynamic interactions and cooperative functions of PGC-1alpha and MED1 in TRalpha-mediated activation of the brown-fat-specific UCP-1 gene
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Population-level transcription cycles derive from stochastic timing of single-cell transcription
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Complexity in transcription control at the activation domain-mediator interface
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Malleable machines in transcription regulation: the mediator complex
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Role for Med12 in regulation of Nanog and Nanog target genes
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29 September 2017
MyoD targets TAF3/TRF3 to activate myogenin transcription.
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29 September 2017
Promoter proximal pausing on genes in metazoans
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E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8
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29 September 2017
Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation
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29 September 2017
Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.
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29 September 2017
Transcription regulation through promoter-proximal pausing of RNA polymerase II.
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29 September 2017
STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation
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29 September 2017
Genome-wide location of the coactivator mediator: Binding without activation and transient Cdk8 interaction on DNA.
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29 September 2017
Genome-wide occupancy profile of mediator and the Srb8-11 module reveals interactions with coding regions
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29 September 2017
MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid receptor
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29 September 2017
Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin
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29 September 2017
Thyroid hormone-induced juxtaposition of regulatory elements/factors and chromatin remodeling of Crabp1 dependent on MED1/TRAP220.
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29 September 2017
Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking
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29 September 2017
Structure of eukaryotic Mediator complexes
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29 September 2017
Mediator requirement for both recruitment and postrecruitment steps in transcription initiation
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29 September 2017
Structure and mechanism of the RNA polymerase II transcription machinery
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29 September 2017
Activation domain–mediator interactions promote transcription preinitiation complex assembly on promoter DNA
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29 September 2017
Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression
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29 September 2017
Phosphorylation of histone H3 is functionally linked to retinoic acid receptor beta promoter activation
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29 September 2017
Independent dynamic regulation of histone phosphorylation and acetylation during immediate-early gene induction
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29 September 2017
Novel critical role of a human Mediator complex for basal RNA polymerase II transcription
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29 September 2017
Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation
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29 September 2017
Activated transcription independent of the RNA polymerase II holoenzyme in budding yeast
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29 September 2017
p53 activates transcription by directing structural shifts in Mediator
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2 June 2018
The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function
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2 June 2018
Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly
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2 June 2018
Structural and functional characterization of PC2 and RNA polymerase II-associated subpopulations of metazoan Mediator
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2 June 2018
Transcriptional activation independent of TFIIH kinase and the RNA polymerase II mediator in vivo
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2 June 2018
PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation.
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A mechanism for coordinating chromatin modification and preinitiation complex assembly.
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27 November 2018
Head module control of mediator interactions
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27 November 2018
Mediator is a transducer of Wnt/beta-catenin signaling.
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27 November 2018
Distinct conformational states of nuclear receptor-bound CRSP-Med complexes
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27 November 2018
Structure and function of CRSP/Med2; a promoter-selective transcriptional coactivator complex
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891401
retrieved
27 November 2018
A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2891401
retrieved
27 November 2018
Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20299225
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.TIBS.2010.02.004
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4827393
OpenCitations bibliographic resource ID
4827393
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4827393
PMC publication ID
2891401
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4827393
PubMed publication ID
20299225
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4827393
ResearchGate publication ID
42344810
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