(Q28286138)

NAALADase inhibitors: A novel approach to glutamate regulation

31 March 2020

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N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system

31 March 2020

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The nagging question of the function of N-acetylaspartylglutamate

31 March 2020

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N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells

31 March 2020

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N-acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes.

31 March 2020

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N-acetylaspartylglutamate inhibits forskolin-stimulated cyclic AMP levels via a metabotropic glutamate receptor in cultured cerebellar granule cells

31 March 2020

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Regulation of neurotransmitter release by metabotropic glutamate receptors

31 March 2020

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Metabotropic glutamate receptor involvement in models of acute and persistent pain: prospects for the development of novel analgesics

31 March 2020

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A study of possible excitatory effects of N-acetylaspartylglutamate in different in vivo and in vitro brain preparations

31 March 2020

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Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase

31 March 2020

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Molecular cloning of a peptidase against N-acetylaspartylglutamate from a rat hippocampal cDNA library

31 March 2020

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The cloning and characterization of a second brain enzyme with NAAG peptidase activity

31 March 2020

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Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene

31 March 2020

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Cloning, expression, genomic localization, and enzymatic activities of the mouse homolog of prostate-specific membrane antigen/NAALADase/folate hydrolase

31 March 2020

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GCP II (NAALADase) inhibition suppresses mossy fiber-CA3 synaptic neurotransmission by a presynaptic mechanism

31 March 2020

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Neuroprotective activity of N-acetylaspartylglutamate in cultured cortical cells.

31 March 2020

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Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury

31 March 2020

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Neuroprotection mediated by glutamate carboxypeptidase II (NAALADase) inhibition requires TGF-beta

31 March 2020

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Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase

31 March 2020

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N-acetylaspartylglutamate and β-NAAG protect against injury induced by NMDA and hypoxia in primary spinal cord cultures

31 March 2020

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Glutamate in CNS disorders as a target for drug development: an update

31 March 2020

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The central nervous system effects, pharmacokinetics and safety of the NAALADase-inhibitor GPI 5693.

31 March 2020

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Site-directed mutagenesis of predicted active site residues in glutamate carboxypeptidase II.

31 March 2020

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Early embryonic death of glutamate carboxypeptidase II (NAALADase) homozygous mutants

31 March 2020

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Aminopeptidase from Streptomyces griseus: primary structure and comparison with other zinc-containing aminopeptidases

31 March 2020

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Cloning and nucleotide sequence of the Vibrio proteolyticus aminopeptidase gene

31 March 2020

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[Significance of prostate-specific membrane antigen (PSMA). A neurocarboxypeptidase and membrane folate hydrolase]

31 March 2020

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Structure of membrane glutamate carboxypeptidase.

31 March 2020

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The extracellular regions of PSMA and the transferrin receptor contain an aminopeptidase domain: implications for drug design

31 March 2020

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Molecular modeling of the interactions of glutamate carboxypeptidase II with its potent NAAG-based inhibitors

31 March 2020

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Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase

31 March 2020

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Synthesis of acyclic and dehydroaspartic acid analogues of Ac-Asp-Glu-OH and their inhibition of rat brain N-acetylated alpha-linked acidic dipeptidase (NAALA dipeptidase).

31 March 2020

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Design of NAALADase inhibitors: a novel neuroprotective strategy

31 March 2020

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Design and pharmacological activity of phosphinic acid based NAALADase inhibitors

31 March 2020

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Phosphonate and phosphinate analogues of N-acylated gamma-glutamylglutamate. potent inhibitors of glutamate carboxypeptidase II.

31 March 2020

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Prostate targeting ligands based on N-acetylated alpha-linked acidic dipeptidase

31 March 2020

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Conformational and SAR analysis of NAALADase and PSMA inhibitors

31 March 2020

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Probing for a hydrophobic a binding register in prostate-specific membrane antigen with phenylalkylphosphonamidates

31 March 2020

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Enantiospecificity of glutamate carboxypeptidase II inhibition

31 March 2020

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Synthesis and Biological Evaluation of Thiol-Based Inhibitors of Glutamate Carboxypeptidase II: Discovery of an Orally Active GCP II Inhibitor

31 March 2020

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Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II.

31 March 2020

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Syntheses of conformationally constricted molecules as potential NAALADase/PSMA inhibitors

31 March 2020

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Synthesis of modular dipeptide mimetics on the basis of diazabicycloalkanes and derivatives thereof with sulphur containing side chains

31 March 2020

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Dual function glutamate-related ligands: discovery of a novel, potent inhibitor of glutamate carboxypeptidase II possessing mGluR3 agonist activity

31 March 2020

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Design of remarkably simple, yet potent urea-based inhibitors of glutamate carboxypeptidase II (NAALADase)

31 March 2020

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Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents

31 March 2020

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Spinal N-acetyl-alpha-linked acidic dipeptidase (NAALADase) inhibition attenuates mechanical allodynia induced by paw carrageenan injection in the rat.

31 March 2020

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Inhibition of spinal N-acetylated-alpha-linked acidic dipeptidase produces an antinociceptive effect in the rat formalin test

31 March 2020

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Effect of 2-(phosphono-methyl)-pentanedioic acid on allodynia and afferent ectopic discharges in a rat model of neuropathic pain

31 March 2020

1 reference

Effects of GCP-II inhibition on responses of dorsal horn neurones after inflammation and neuropathy: an electrophysiological study in the rat.

31 March 2020

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Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model

31 March 2020

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NAAG fails to antagonize synaptic and extrasynaptic NMDA receptors in cerebellar granule neurons.

31 March 2020

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NAAG reduces NMDA receptor current in CA1 hippocampal pyramidal neurons of acute slices and dissociated neurons

31 March 2020

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Clinical trials in head injury

31 March 2020

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Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study

31 March 2020

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Critical appraisal of neuroprotection trials in head injury: what have we learned?

31 March 2020

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The role of excitatory amino acids and NMDA receptors in traumatic brain injury

31 March 2020

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Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury

31 March 2020

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Current status of neuroprotection trials for traumatic brain injury: lessons from animal models and clinical studies

31 March 2020

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NAAG peptidase inhibitor reduces acute neuronal degeneration and astrocyte damage following lateral fluid percussion TBI in rats

31 March 2020

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Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels.

31 March 2020

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Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis.

31 March 2020

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Neuroprotection for acute stroke: making clinical trials work

31 March 2020

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Neuroprotective effects of N-acetylaspartylglutamate in a neonatal rat model of hypoxia-ischemia

31 March 2020

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The current status of the dopamine hypothesis of schizophrenia

31 March 2020

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Abnormal excitatory neurotransmitter metabolism in schizophrenic brains

31 March 2020

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Regulation of Glutamate Carboxypeptidase II Function in Corticolimbic Regions of Rat Brain by Phencyclidine, Haloperidol, and Clozapine

31 March 2020

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Glutamatergic mechanisms in schizophrenia

31 March 2020

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Cognitive dysfunction in schizophrenia: unifying basic research and clinical aspects

31 March 2020

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Sernyl (CI-395) in clinical anaesthesia.

31 March 2020

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Recent advances in the phencyclidine model of schizophrenia

31 March 2020

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Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats

31 March 2020

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NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR.

31 March 2020

1 reference

Diabetic neuropathy: pathogenetic background, current and future therapies

31 March 2020

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Protection against glucose-induced neuronal death by NAAG and GCP II inhibition is regulated by mGluR3

31 March 2020

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Vascular Risk Factors and Diabetic Neuropathy

31 March 2020

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Slowing of motor nerve conduction velocity in streptozotocin-induced diabetic rats is preceded by impaired vasodilation in arterioles that overlie the sciatic nerve

31 March 2020

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Diabetic peripheral neuropathy: evidence for apoptosis and associated mitochondrial dysfunction

31 March 2020

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Upregulation of mRNAs coding for AMPA and NMDA receptor subunits and metabotropic glutamate receptors in the dorsal horn of the spinal cord in a rat model of diabetes mellitus

31 March 2020

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GCPII (NAALADase) inhibition prevents long-term diabetic neuropathy in type 1 diabetic BB/Wor rats

31 March 2020

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From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS

31 March 2020

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Physiopathology of ALS: therapeutic approach

31 March 2020

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Pharmacologic approaches to the treatment of amyotrophic lateral sclerosis

31 March 2020

1 reference

Deficient RNA editing of GluR2 and neuronal death in amyotropic lateral sclerosis

31 March 2020

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Antisense peptide nucleic acid targeting GluR3 delays disease onset and progression in the SOD1 G93A mouse model of familial ALS.

31 March 2020

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Increased internalisation and degradation of GLT-1 glial glutamate transporter in a cell model for familial amyotrophic lateral sclerosis (ALS).

31 March 2020

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Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models

31 March 2020

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Biaryl Analogues of Conformationally Constrained Tricyclic Tropanes as Potent and Selective Norepinephrine Reuptake Inhibitors: Synthesis and Evaluation of Their Uptake Inhibition at Monoamine Transporter Sites

31 March 2020

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Glutamate systems in cocaine addiction

31 March 2020

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Glutamate transmission and addiction to cocaine.

31 March 2020

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Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse

31 March 2020

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Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour

31 March 2020

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Metabotropic glutamate receptor 2/3-dependent long-term depression in the nucleus accumbens is blocked in morphine withdrawn mice.

31 March 2020

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Morphine-induced dependence and sensitization are altered in mice deficient in AMPA-type glutamate receptor-A subunits.

31 March 2020

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Neural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal

31 March 2020

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Imbalance between neuroexcitatory and neuroinhibitory amino acids causes craving for ethanol

31 March 2020

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Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking

31 March 2020

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The ups and downs of addiction: role of metabotropic glutamate receptors

31 March 2020

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Plastic control of striatal glutamatergic transmission by ensemble actions of several neurotransmitters and targets for drugs of abuse

31 March 2020

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Glutamatergic mechanisms in addiction

31 March 2020

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Expression and acquisition of the conditioned place preference response to cocaine in rats is blocked by selective inhibitors of the enzyme N-acetylated-alpha-linked-acidic dipeptidase (NAALADASE).

31 March 2020

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NAALADase (GCP II) inhibition prevents cocaine-kindled seizures

31 March 2020

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Morphine tolerance and reward but not expression of morphine dependence are inhibited by the selective glutamate carboxypeptidase II (GCP II, NAALADase) inhibitor, 2-PMPA.

31 March 2020

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NAALADase inhibition reduces alcohol consumption in the alcohol-preferring (P) line of rats.

31 March 2020

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Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease

31 March 2020

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Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease

31 March 2020

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N-acetylaspartate and N-acetylaspartylglutamate levels in Alzheimer's disease post-mortem brain tissue.

31 March 2020

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Distribution of N-acetylaspartylglutamate immunoreactivity in human brain and its alteration in neurodegenerative disease

31 March 2020

1 reference

N-acetylaspartylglutamate, N-acetylaspartate, and N-acetylated alpha-linked acidic dipeptidase in human brain and their alterations in Huntington and Alzheimer's diseases

31 March 2020

1 reference

31 March 2020

Cancer statistics, 2002

1 reference

Targeting prostate-specific membrane antigen in cancer therapy: can molecular medicine be brought to the surface?

31 March 2020

1 reference

Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer

31 March 2020

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The clinical role of prostate-specific membrane antigen (PSMA)

31 March 2020

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Phase I trial of yttrium-90-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 for androgen-independent prostate cancer

31 March 2020

1 reference

Imaging with radiolabelled monoclonal antibody (MUJ591) to prostate-specific membrane antigen in staging of clinically localized prostatic carcinoma: comparison with clinical, surgical and histological staging.

31 March 2020

1 reference

11C-MCG: synthesis, uptake selectivity, and primate PET of a probe for glutamate carboxypeptidase II (NAALADase).

31 March 2020

1 reference

Radiolabeled small-molecule ligands for prostate-specific membrane antigen: in vivo imaging in experimental models of prostate cancer

31 March 2020

1 reference