(Q28287173)

Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids

PubMed

volume

8

0 references

issue

5

0 references

page(s)

509-22

0 references

cites work

1 reference

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Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain

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Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice

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Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

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Brain monoglyceride lipase participating in endocannabinoid inactivation

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Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha

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Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents

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Chemical characterization of a family of brain lipids that induce sleep

20 April 2017

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siRNA knockdown of GPR18 receptors in BV-2 microglia attenuates N-arachidonoyl glycine-induced cell migration

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N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties

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A FAAH-regulated class of N-acyl taurines that activates TRP ion channels

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A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol

20 April 2017

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Endocannabinoid oxygenation by cyclooxygenases, lipoxygenases, and cytochromes P450: cross-talk between the eicosanoid and endocannabinoid signaling pathways

20 April 2017

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Discovery of prostamide F2α and its role in inflammatory pain and dorsal horn nociceptive neuron hyperexcitability

20 April 2017

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Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

20 April 2017

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Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling

20 April 2017

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Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity

20 April 2017

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Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by α-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures

20 April 2017

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X-ray Crystallographic Analysis of α-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide Hydrolase

20 April 2017

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Identification of potent, noncovalent fatty acid amide hydrolase (FAAH) inhibitors

20 April 2017

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Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies

20 April 2017

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Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes

20 April 2017

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Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

20 April 2017

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Structure-guided inhibitor design for human FAAH by interspecies active site conversion

20 April 2017

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Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas

20 April 2017

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Paracrinicity: the story of 30 years of cellular pituitary crosstalk

20 April 2017

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Endocannabinoid biosynthesis and inactivation, from simple to complex

21 January 2018

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Intracellular trafficking of anandamide: new concepts for signaling.

21 January 2018

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DAG Lipase Involvement in Depolarization-Induced Suppression of Inhibition: Does Endocannabinoid Biosynthesis Always Meet the Demand?

21 January 2018

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Anandamide induced PPARgamma transcriptional activation and 3T3-L1 preadipocyte differentiation

21 January 2018

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Endocannabinoids as regulators of transient receptor potential (TRP) channels: A further opportunity to develop new endocannabinoid-based therapeutic drugs

21 January 2018

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The major central endocannabinoid directly acts at GABA(A) receptors

21 January 2018

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Enzymatic formation of anandamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.780021

Evidence for bidirectional endocannabinoid transport across cell membranes

21 January 2018

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Targeting the endocannabinoid system: to enhance or reduce?

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.780021

The endocannabinoid system and pain

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2013.780021

Short- and long-term plasticity of the endocannabinoid system in neuropsychiatric and neurological disorders

21 January 2018

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Central and peripheral cannabinoid receptors as therapeutic targets in the control of food intake and body weight

21 January 2018

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Endocannabinoids and the cardiovascular response to stress.

21 January 2018

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The endocannabinoid system in the cancer therapy: an overview.

21 January 2018

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Alternative targets within the endocannabinoid system for future treatment of gastrointestinal diseases

21 January 2018

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N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA).

21 January 2018

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Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists

21 January 2018

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A second fatty acid amide hydrolase with variable distribution among placental mammals

21 January 2018

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Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors

21 January 2018

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Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain.

21 January 2018

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Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2

21 January 2018

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Oxidative metabolism of endocannabinoids

21 January 2018

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Oxidation of the endogenous cannabinoid arachidonoyl ethanolamide by the cytochrome P450 monooxygenases: physiological and pharmacological implications

21 January 2018

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Oxygenated metabolites of anandamide and 2-arachidonoylglycerol: conformational analysis and interaction with cannabinoid receptors, membrane transporter, and fatty acid amide hydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.780021

Prostaglandin ethanolamides (prostamides): in vitro pharmacology and metabolism

21 January 2018

1 reference

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Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.780021

The endogenous cannabinoid system protects against colonic inflammation

21 January 2018

1 reference

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Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.780021

Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.780021

Structure and function of fatty acid amide hydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.780021

Fatty acid amide hydrolase: a gate-keeper of the endocannabinoid system

21 January 2018

1 reference

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QM/MM modelling of oleamide hydrolysis in fatty acid amide hydrolase (FAAH) reveals a new mechanism of nucleophile activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.780021

Elucidation of hydrolysis mechanisms for fatty acid amide hydrolase and its Lys142Ala variant via QM/MM simulations

21 January 2018

1 reference

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Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity

21 January 2018

1 reference

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Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets

21 January 2018

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Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors

21 January 2018

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Activity-based protein profiling: the serine hydrolases

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Direct visualization of serine hydrolase activities in complex proteomes using fluorescent active site-directed probes

21 January 2018

1 reference

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Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition

21 January 2018

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Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide

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alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution

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Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics

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Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity

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Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms

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1 reference

https://api.crossref.org/works/10.1517%2F17460441.2013.780021

Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain

21 January 2018

1 reference

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α-Ketoheterocycle-based Inhibitors of Fatty Acid Amide Hydrolase (FAAH).

21 January 2018

1 reference

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Oxime carbamate--discovery of a series of novel FAAH inhibitors

21 January 2018

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A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.

21 January 2018

1 reference

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Enol carbamates as inhibitors of fatty acid amide hydrolase (FAAH) endowed with high selectivity for FAAH over the other targets of the endocannabinoid system

21 January 2018

1 reference

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The novel reversible fatty acid amide hydrolase inhibitor ST4070 increases endocannabinoid brain levels and counteracts neuropathic pain in different animal models.

21 January 2018

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Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.

21 January 2018

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Recent advances in the medicinal chemistry of alpha-aminoboronic acids, amine-carboxyboranes and their derivatives

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Mechanism of inhibition of fatty acid amide hydrolase by sulfonamide-containing benzothiazoles: long residence time derived from increased kinetic barrier and not exclusively from thermodynamic potency

21 January 2018

1 reference

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Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases

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Application of computational methods to the design of fatty acid amide hydrolase (FAAH) inhibitors based on a carbamic template structure

21 January 2018

1 reference

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Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling

21 January 2018

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Covalent inhibitors of fatty acid amide hydrolase: a rationale for the activity of piperidine and piperazine aryl ureas.

21 January 2018

1 reference

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Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.

21 January 2018

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Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).

21 January 2018

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Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors

21 January 2018

1 reference

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Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models

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Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors

21 January 2018

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The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition

21 January 2018

1 reference

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Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress

21 January 2018

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Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor

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An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis

21 January 2018

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Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase

21 January 2018

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Sulfonyl fluoride inhibitors of fatty acid amide hydrolase

21 January 2018

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Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice.

21 January 2018

1 reference

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Assessment of the pharmacology and tolerability of PF-04457845, an irreversible inhibitor of fatty acid amide hydrolase-1, in healthy subjects

21 January 2018

1 reference

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Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain

21 January 2018

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