(Q28293369)

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Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake

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Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake (English)

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Graziano Pinna

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author name string

Erminio Costa

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Alessandro Guidotti

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publication date

June 2006

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Psychopharmacology

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186

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362-72

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3

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https://scigraph.springernature.com/pub.10.1007/s00213-005-0213-2

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Norepinephrine in depressive reactions. A review

1 reference

https://api.crossref.org/works/10.1007%2FS00213-005-0213-2

21 January 2018

Fluoxetine and impulsive aggressive behavior in personality-disordered subjects

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21 January 2018

The catecholamine hypothesis of affective disorders: a review of supporting evidence

1 reference

https://api.crossref.org/works/10.1007%2FS00213-005-0213-2

21 January 2018

Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain.

1 reference

https://api.crossref.org/works/10.1007%2FS00213-005-0213-2

21 January 2018

Neurosteroidogenesis: relevance to neurosteroid actions in brain and modulation by psychotropic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Social isolation stress-induced aggression in mice: a model to study the pharmacology of neurosteroidogenesis

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

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Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes

1 reference

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12 December 2020

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Selective serotonin reuptake inhibitors for premenstrual dysphoric disorder: the emerging gold standard?

1 reference

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12 December 2020

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Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine

1 reference

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12 December 2020

based on heuristic

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Selectivity of antidepressants: from the monoamine hypothesis of depression to the SSRI revolution and beyond.

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

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Changes in brain testosterone and allopregnanolone biosynthesis elicit aggressive behavior

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

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GABA(A) receptor alpha4 subunit suppression prevents withdrawal properties of an endogenous steroid.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

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Neurosteroidal modulation of social isolation-induced decrease in pentobarbital sleep in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective versus multi-transmitter antidepressants: are two mechanisms better than one?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

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GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

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Neurosteroids in depression: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

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Brain 5alpha-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation

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https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

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Hyperactivity of central noradrenergic and CRF systems is involved in social isolation-induced decrease in pentobarbital sleep.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of hippocampal cell proliferation, memory, and amyloid plaque deposition in APPsw (Tg2576) mutant mice by isolation stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From monoamines to genomic targets: a paradigm shift for drug discovery in depression

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serotonergic agents modulate antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5α-dihydroprogesterone in psychiatric disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of recombinant gamma-aminobutyric acid-A receptor subunit composition on the action of allosteric modulators of gamma-aminobutyric acid-gated Cl- currents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GABAA receptors and benzodiazepines: a role for dendritic resident subunit mRNAs

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroactive steroids and anxiety disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Psychopharmacology of Aggression: an Overview

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How antidepressants help depression: mechanisms of action and clinical response

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The serotonergic and noradrenergic systems of the hippocampus: their interactions and the effects of antidepressant treatments

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

History and evolution of the monoamine hypothesis of depression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR)

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pregnenolone sulfate antagonizes GABAA receptor-mediated currents via a reduction of channel opening frequency

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

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Chronic treatment with the neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The dual-action hypothesis: does pharmacology matter?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacokinetics of fluoxetine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroactive steroids

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of brain allopregnanolone in the plasticity of gamma-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

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Anxiolytic activity of progesterone in progesterone receptor knockout mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

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Benzodiazepines on trial: a research strategy for their rehabilitation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

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Chronic stress and social housing differentially affect neurogenesis in male and female rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

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Gas chromatographic-mass fragmentographic quantitation of 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) and its precursors in blood and brain of adrenalectomized and castrated rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluoxetine in the treatment of premenstrual dysphoria. Canadian Fluoxetine/Premenstrual Dysphoria Collaborative Study Group.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic effect of progesterone is associated with increases in cortical allopregnanolone and GABAA receptor function.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurobiology of mood, anxiety, and emotions as revealed by studies of a unique antidepressant: tianeptine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice forced swim test.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tianeptine decreases both serotonin transporter mRNA and binding sites in rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biochemistry of affective disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current advances and trends in the treatment of depression

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anticonvulsant profile of the progesterone metabolite 5 alpha-pregnan-3 alpha-ol-20-one

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurosteroids: endogenous regulators of the GABA(A) receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurosteroids act on recombinant human GABAA receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological antidepressive effects and tianeptine-induced 5-HT uptake increase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Allopregnanolone levels and reactivity to mental stress in premenstrual dysphoric disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain allopregnanolone regulates the potency of the GABAA receptor agonist muscimol

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic antidepressants reverse cerebrocortical allopregnanolone decline in the olfactory-bulbectomized rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-activity relationships in steroidal anaesthetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurosteroids and neuroactive drugs in mental disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tianeptine, a selective enhancer of serotonin uptake in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurobiology of depression

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

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Stress and neuroactive steroids

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

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Neurosteroids: endogenous bimodal modulators of the GABAA receptor. Mechanism of action and physiological significance

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma concentrations of anxiolytic neuroactive steroids in men with panic disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essentiality of central GABAergic neuroactive steroid allopregnanolone for anticonvulsant action of fluoxetine against pentylenetetrazole-induced seizures in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

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Alprazolam dependence prevented by substituting with the beta-carboline abecarnil

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal of caffeine-induced anxiety by neurosteroid 3-alpha-hydroxy-5-alpha-pregnane-20-one in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Permissive role of brain allopregnanolone content in the regulation of pentobarbital-induced righting reflex loss.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developments in the drug treatment of panic disorder: what is the place of the selective serotonin reuptake inhibitors?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serotonin and its place in the pathogenesis of depression

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Does neurosteroid modulatory efficacy depend on GABAA receptor subunit composition?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurosteroids: beginning of the story

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The anticonvulsant action of fluoxetine in substantia nigra is dependent upon endogenous serotonin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Can the antidysphoric and anxiolytic profiles of selective serotonin reuptake inhibitors be related to their ability to increase brain 3 alpha, 5 alpha-tetrahydroprogesterone (allopregnanolone) availability?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is mood chemistry?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term social isolation enhances picrotoxin seizure susceptibility in mice: up-regulatory role of endogenous brain allopregnanolone in GABAergic systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Are two antidepressant mechanisms better than one? Issues in clinical trial design and analysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of fluoxetine in the treatment of premenstrual dysphoric disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluoxetine and seizures

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anticonvulsant effect of fluoxetine in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Steroids, neuroactive steroids and neurosteroids in psychopathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of subunit composition on the interaction of neurosteroids with GABA(A) receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Premenstrual dysphoria and the serotonin system: pathophysiology and treatment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurosteroid modulation of GABAA receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain neurosteroids in gender-related aggression induced by social isolation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the putative physiological role of allopregnanolone on GABA(A) receptor function

1 reference

https://pubmed.ncbi.nlm.nih.gov/16432684

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00213-005-0213-2

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