(Q28302027)

The IKK Kinases: Operators of Antiviral Signaling

PubMed

volume

2

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issue

4

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page(s)

481-98

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cites work

1 reference

Crystal structure of inhibitor of κB kinase β

21 January 2018

1 reference

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

21 January 2018

1 reference

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

21 January 2018

1 reference

Activators and target genes of Rel/NF-kappaB transcription factors

21 January 2018

1 reference

Regulation of cell death and autophagy by IKK and NF-κB: critical mechanisms in immune function and cancer

21 January 2018

1 reference

Good cop, bad cop: the different faces of NF-kappaB

21 January 2018

1 reference

NF-κB regulation: lessons from structures

21 January 2018

1 reference

It takes two to tango: IκBs, the multifunctional partners of NF-κB.

21 January 2018

1 reference

The two NF-kappaB activation pathways and their role in innate and adaptive immunity

21 January 2018

1 reference

Shared principles in NF-kappaB signaling

21 January 2018

1 reference

The IKK NF-kappa B system: a treasure trove for drug development

21 January 2018

1 reference

Integrating cell-signalling pathways with NF-kappaB and IKK function

21 January 2018

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Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

21 January 2018

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Non-canonical NF-κB signaling pathway

21 January 2018

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Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation

21 January 2018

1 reference

Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation

21 January 2018

1 reference

The noncanonical NF-κB pathway

21 January 2018

1 reference

IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer

21 January 2018

1 reference

Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB

21 January 2018

1 reference

Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin

21 January 2018

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Nuclear factor κB predicts poor outcome in patients with hormone-naive prostate cancer with high nuclear androgen receptor.

21 January 2018

1 reference

NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase

21 January 2018

1 reference

IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases

21 January 2018

1 reference

IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex

21 January 2018

1 reference

Structure and ubiquitination-dependent activation of TANK-binding kinase 1.

21 January 2018

1 reference

Crystal structure and mechanism of activation of TANK-binding kinase 1

21 January 2018

1 reference

Emerging roles for the non-canonical IKKs in cancer

21 January 2018

1 reference

Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?

21 January 2018

1 reference

Triggering the interferon antiviral response through an IKK-related pathway

21 January 2018

1 reference

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

21 January 2018

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Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction

21 January 2018

1 reference

Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity

21 January 2018

1 reference

IκB kinase epsilon (IKK(epsilon)) regulates the balance between type I and type II interferon responses

21 January 2018

1 reference

IKKepsilon: a bridge between obesity and inflammation

21 January 2018

1 reference

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

21 January 2018

1 reference

Small-molecule inducer of β cell proliferation identified by high-throughput screening.

21 January 2018

1 reference

Integrative genomic approaches identify IKBKE as a breast cancer oncogene

21 January 2018

1 reference

Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer

21 January 2018

1 reference

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

21 January 2018

1 reference

Inhibition of human immunodeficiency virus type 1 replication by blocking IkappaB kinase with noraristeromycin

21 January 2018

1 reference

Discovery of piperidinyl aminopyrimidine derivatives as IKK-2 inhibitors.

21 January 2018

1 reference

Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis.

21 January 2018

1 reference

Discovery of imidazo[1,2-b]pyridazine derivatives as IKKbeta inhibitors. Part 1: Hit-to-lead study and structure-activity relationship

21 January 2018

1 reference

Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 2: improvement of potency in vitro and in vivo.

21 January 2018

1 reference

Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 3: exploration of effective compounds in arthritis models.

21 January 2018

1 reference

Discovery of 6-aryl-7-alkoxyisoquinoline inhibitors of IkappaB kinase-beta (IKK-beta).

21 January 2018

1 reference

4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy

21 January 2018

1 reference

Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.

21 January 2018

1 reference

Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

21 January 2018

1 reference

Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKε kinases

21 January 2018

1 reference

Drug Discovery in Academia- the third way?

21 January 2018

1 reference

Drug discovery in an academic setting: playing to the strengths

21 January 2018

1 reference