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NF-κB regulation: lessons from structures
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scholarly article
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stated in
PubMed
title
NF-κB regulation: lessons from structures
(English)
1 reference
stated in
PubMed
main subject
NF-κB
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author name string
Gourisankar Ghosh
series ordinal
1
1 reference
stated in
Crossref
Vivien Ya-Fan Wang
series ordinal
2
1 reference
stated in
Crossref
De-Bin Huang
series ordinal
3
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stated in
Crossref
Amanda Fusco
series ordinal
4
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stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
March 2012
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stated in
PubMed
published in
Immunological Reviews
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stated in
PubMed
volume
246
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stated in
PubMed
issue
1
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stated in
PubMed
page(s)
36-58
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PubMed
cites work
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NF-kappaB p52:RelB heterodimer recognizes two classes of kappaB sites with two distinct modes
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21 March 2017
Generation and activation of multiple dimeric transcription factors within the NF-kappaB signaling system
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21 March 2017
A fourth IkappaB protein within the NF-kappaB signaling module
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21 March 2017
Recruitment of IkappaBalpha to the hes1 promoter is associated with transcriptional repression
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21 March 2017
Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)
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21 March 2017
Designed to be stable: crystal structure of a consensus ankyrin repeat protein
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21 March 2017
Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor
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21 March 2017
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
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21 March 2017
NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100
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21 March 2017
A subclass of Ras proteins that regulate the degradation of IkappaB
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21 March 2017
Structure of an IkappaBalpha/NF-kappaB complex
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21 March 2017
Identification of the receptor component of the IkappaBalpha-ubiquitin ligase
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21 March 2017
A novel DNA recognition mode by the NF-kappa B p65 homodimer
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21 March 2017
A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription
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21 March 2017
I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity
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PubMed Central
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21 March 2017
Multiple nuclear factors interact with the immunoglobulin enhancer sequences
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21 March 2017
Crystal structure of inhibitor of κB kinase β
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21 March 2017
Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation
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21 March 2017
Structural Basis for Recognition of Diubiquitins by NEMO
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21 March 2017
Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome
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21 March 2017
Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site
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21 March 2017
Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation
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21 March 2017
X-ray Structure of a NF-κB p50/RelB/DNA Complex Reveals Assembly of Multiple Dimers on Tandem κB Sites
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21 March 2017
An Atomic Model of the Interferon-β Enhanceosome
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21 March 2017
Crystal structure of NF- B (p50)2 complexed to a high-affinity RNA aptamer
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21 March 2017
X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex
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21 March 2017
Structure of NF-kappaB p50/p65 heterodimer bound to the PRDII DNA element from the interferon-beta promoter
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21 March 2017
The kappa B DNA sequence from the HIV long terminal repeat functions as an allosteric regulator of HIV transcription
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21 March 2017
The x-ray crystal structure of the NF-kappa B p50.p65 heterodimer bound to the interferon beta -kappa B site
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21 March 2017
X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2
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21 March 2017
Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha
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21 March 2017
NF-kappa B binding mechanism: a nuclear magnetic resonance and modeling study of a GGG --> CTC mutation
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21 March 2017
The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation
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21 March 2017
Solution structure of a non-palindromic 16 base-pair DNA related to the HIV-1 kappa B site: evidence for BI-BII equilibrium inducing a global dynamic curvature of the duplex
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21 March 2017
Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA
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21 March 2017
The role of DNA in the mechanism of NFkappaB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits
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21 March 2017
Structure of the NF-kappa B p50 homodimer bound to DNA
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21 March 2017
Structure of NF-kappa B p50 homodimer bound to a kappa B site
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21 March 2017
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity
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21 March 2017
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses
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21 March 2017
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7 April 2017
Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation
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21 March 2017
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway
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21 March 2017
Introduction to NF-kappaB: players, pathways, perspectives
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21 March 2017
Regulation and function of IKK and IKK-related kinases
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21 March 2017
Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate
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21 March 2017
Hundreds of ankyrin-like repeats in functionally diverse proteins: mobile modules that cross phyla horizontally?
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21 March 2017
MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production
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21 March 2017
NF-kappaB dictates the degradation pathway of IkappaBalpha
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21 March 2017
Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300
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21 March 2017
Shared principles in NF-kappaB signaling
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7 April 2017
Activators and target genes of Rel/NF-kappaB transcription factors
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7 April 2017
Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis
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7 April 2017
Ubiquitin signalling in the NF-kappaB pathway
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7 April 2017
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation
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7 April 2017
The specificity of innate immune responses is enforced by repression of interferon response elements by NF-κB p50
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28 September 2017
Detection of a ternary complex of NF-kappaB and IkappaBalpha with DNA provides insights into how IkappaBalpha removes NF-kappaB from transcription sites
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28 September 2017
IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response
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28 September 2017
The IKK complex, a central regulator of NF-kappaB activation
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28 September 2017
Kinetic enhancement of NF-kappaBxDNA dissociation by IkappaBalpha
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28 September 2017
Regulation of NF-kappaB activity through lysine monomethylation of p65.
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28 September 2017
The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes
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28 September 2017
Kinetic control of negative feedback regulators of NF-kappaB/RelA determines their pathogen- and cytokine-receptor signaling specificity
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28 September 2017
NF-kappa B1 p105 regulates T cell homeostasis and prevents chronic inflammation
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28 September 2017
The zinc finger of NEMO is a functional ubiquitin-binding domain
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28 September 2017
Bcl-3, a multifaceted modulator of NF-kappaB-mediated gene transcription
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28 September 2017
Integrating computational and biochemical studies to explore mechanisms in NF-{kappa}B signaling
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28 September 2017
Molecular dynamics of a kappaB DNA element: base flipping via cross-strand intercalative stacking in a microsecond-scale simulation
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28 September 2017
Pre-folding IkappaBalpha alters control of NF-kappaB signaling
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28 September 2017
A primer on ankyrin repeat function in TRP channels and beyond
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28 September 2017
Repression of gene expression by unphosphorylated NF-kappaB p65 through epigenetic mechanisms.
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28 September 2017
Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity
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28 September 2017
IkappaBepsilon provides negative feedback to control NF-kappaB oscillations, signaling dynamics, and inflammatory gene expression.
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28 September 2017
A pervasive role of ubiquitin conjugation in activation and termination of IkappaB kinase pathways
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28 September 2017
Crystal structure of a free kappaB DNA: insights into DNA recognition by transcription factor NF-kappaB.
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28 September 2017
The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1.
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28 September 2017
Biophysical characterization of the free IkappaBalpha ankyrin repeat domain in solution.
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28 September 2017
Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation
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28 September 2017
Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras
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28 September 2017
Discreet mutations from c-Rel to v-Rel alter kappaB DNA recognition, IkappaBalpha binding, and dimerization: implications for v-Rel oncogenicity
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28 September 2017
Differential phosphorylation of the signal-responsive domain of I kappa B alpha and I kappa B beta by I kappa B kinases
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28 September 2017
A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei
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28 September 2017
Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs
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28 September 2017
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28 September 2017
Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2.
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28 September 2017
Common structural constituents confer I kappa B activity to NF-kappa B p105 and I kappa B/MAD-3.
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28 September 2017
The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control
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28 September 2017
The ankyrin repeat domains of the NF-kappa B precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-kappa B DNA binding
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28 September 2017
IkappaBbeta is an essential co-activator for LPS-induced IL-1beta transcription in vivo.
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31 May 2018
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31 May 2018
NF-kappaB RelB forms an intertwined homodimer
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31 May 2018
Distinct roles of IkappaB proteins in regulating constitutive NF-kappaB activity.
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31 May 2018
NF-kappaB p65 (RelA) homodimer uses distinct mechanisms to recognize DNA targets
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31 May 2018
Characterization of the dimer interface of transcription factor NFkappaB p50 homodimer
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31 May 2018
Structure of the human NF-kappaB p52 homodimer-DNA complex at 2.1 A resolution
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31 May 2018
I kappa B proteins: structure, function and regulation
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31 May 2018
NF-kappa B precursor p100 inhibits nuclear translocation and DNA binding of NF-kappa B/rel-factors.
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31 May 2018
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31 May 2018
Molecular cloning and characterization of a novel Rel/NF-kappa B family member displaying structural and functional homology to NF-kappa B p50/p105.
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One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers
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Thermodynamics reveal that helix four in the NLS of NF-kappaB p65 anchors IkappaBalpha, forming a very stable complex.
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Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-kappaB1) but expressing p50.
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Proteolysis of NF-kappaB1 p105 is essential for T cell antigen receptor-induced proliferation
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Direct Phosphorylation of IB by IKK and IKK: Discrimination Between Free and NF-B-Bound Substrate
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21 January 2018
Tumor necrosis factor-alpha-induced apoptosis in prostate cancer cells through inhibition of nuclear factor-kappaB by an IkappaBalpha "super-repressor"
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28 November 2018
Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption
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based on heuristic
inferred from PubMed ID database lookup
I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B
1 reference
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based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1111/J.1600-065X.2012.01097.X
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2552821
OpenCitations bibliographic resource ID
2552821
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2552821
PMCID
4543363
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2552821
PubMed ID
22435546
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2552821
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