(Q28304273)

5

Anthea Hardcastle

0 references

Simon Pacey

1

Simon Pacey

0 references

Wynne Aherne

12

Wynne Aherne

0 references

Florence Raynaud

14

Florence Raynaud

0 references

Ian Judson

16

Ian Judson

0 references

author name string

Richard H Wilson

2

0 references

Mike Walton

3

0 references

Martin M Eatock

4

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Anna Zetterlund

6

0 references

Hendrik-Tobias Arkenau

7

0 references

Javier Moreno-Farre

8

0 references

Udai Banerji

9

0 references

Belle Roels

10

0 references

Heidi Peachey

11

0 references

Johan S de Bono

describes a project that uses

13

0 references

language of work or name

English

0 references

publication date

15 March 2011

0 references

published in

Clinical Cancer Research

0 references

volume

17

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issue

6

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page(s)

1561-70

0 references

ImageQuant

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3060938/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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20 March 2017

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20 March 2017

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20 March 2017

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Pharmacokinetic-pharmacodynamic relationships for the heat shock protein 90 molecular chaperone inhibitor 17-allylamino, 17-demethoxygeldanamycin in human ovarian cancer xenograft models

6 April 2017

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20 March 2017

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Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance

29 September 2017

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29 September 2017

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Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation study

29 September 2017

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V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors

29 September 2017

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Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin

29 September 2017

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29 September 2017

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In vivo antitumor efficacy of 17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride), a water-soluble geldanamycin derivative

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone.

29 September 2017

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29 September 2017

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Flutamide withdrawal syndrome: its impact on clinical trials in hormone-refractory prostate cancer

29 September 2017

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29 September 2017

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A Phase II trial of 17-allylamino, 17-demethoxygeldanamycin (17-AAG, tanespimycin) in patients with metastatic melanoma.

2 June 2018

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BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90.

27 November 2018

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Fit-for-purpose method development and validation for successful biomarker measurement.

27 November 2018

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Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), in rats and dogs: potential clinical relevance

27 November 2018

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Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies

27 November 2018

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Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models

27 November 2018

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17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts

27 November 2018

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The antiandrogen withdrawal syndrome. Experience in a large cohort of unselected patients with advanced prostate cancer

27 November 2018

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Prostate-specific antigen decline after casodex withdrawal: evidence for an antiandrogen withdrawal syndrome

27 November 2018

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Development and validation of a liquid chromatography/tandem mass spectrometry method for the determination of the novel anticancer agent 17-DMAG in human plasma

27 November 2018

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12 December 2020

Hsp90 Regulates Androgen Receptor Hormone Binding Affinityin Vivo

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12 December 2020

Evaluation of response: new and standard criteria

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12 December 2020

Biomarkers in phase I oncology trials: signal, noise, or expensive distraction?

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12 December 2020

Use of pharmacokinetic/pharmacodynamic biomarkers to support rational cancer drug development

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12 December 2020

Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts

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12 December 2020

Accelerated titration designs for phase I clinical trials in oncology

1 reference

12 December 2020

Biomarkers in early clinical trials: the committed and the skeptics

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12 December 2020

10.1158/1078-0432.CCR-10-1927

Identifiers

DOI

1 reference

release_6lhheerrxre7xj2ru2jzzbtlim

Fatcat ID

0 references

1 reference

1 reference

PubMed publication ID

21278242

1 reference