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DNA-PK: the means to justify the ends?
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Europe PubMed Central
title
DNA-PK: the means to justify the ends?
(English)
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author name string
Katheryn Meek
series ordinal
1
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Van Dang
series ordinal
2
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Susan P Lees-Miller
series ordinal
3
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language of work or name
English
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publication date
2008
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published in
Advances in Immunology
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volume
99
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page(s)
33-58
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cites work
DNA ligase IV-deficient cells are more resistant to ionizing radiation in the absence of Ku70: Implications for DNA double-strand break repair
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structure of human XLF: a twist in nonhomologous DNA end-joining
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Visualization of DNA-induced conformational changes in the DNA repair kinase DNA-PKcs
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rag mutations reveal robust alternative end joining
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA end-joining: from yeast to man
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
End-bridging is required for pol mu to efficiently promote repair of noncomplementary ends by nonhomologous end joining
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synapsis of DNA ends by DNA-dependent protein kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-PKcs mutations in dogs and horses: allele frequency and association with neoplasia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protein phosphatases regulate DNA-dependent protein kinase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interplay between Ku, Artemis, and the DNA-dependent protein kinase catalytic subunit at DNA ends
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations to Ku reveal differences in human somatic cell lines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genetic analysis of the DNA-dependent protein kinase reveals an inhibitory role of Ku in late S-G2 phase DNA double-strand break repair
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The lethality of Ku86 (XRCC5) loss-of-function mutations in human cells is independent of p53 (TP53).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-PK autophosphorylation facilitates Artemis endonuclease activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanistic flexibility as a conserved theme across 3 billion years of nonhomologous DNA end-joining
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ku86 exists as both a full-length and a protease-sensitive natural variant in multiple myeloma cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The leucine rich region of DNA-PKcs contributes to its innate DNA affinity.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-dependent protein kinase: DNA binding and activation in the absence of Ku
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of DNA-dependent protein kinase by single-stranded DNA ends
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Terminal DNA structure and ATP influence binding parameters of the DNA-dependent protein kinase at an early step prior to DNA synapsis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of DNA-PKcs phosphorylation sites in XRCC4 and effects of mutations at these sites on DNA end joining in a cell-free system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Repair of DNA double strand breaks by non-homologous end joining
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ku86 is essential in human somatic cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chromosomal double-strand break repair in Ku80-deficient cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The mechanism of human nonhomologous DNA end joining
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Flexibility in the order of action and in the enzymology of the nuclease, polymerases, and ligase of vertebrate non-homologous DNA end joining: relevance to cancer, aging, and the immune system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Electron microscopy studies on DNA recognition by DNA-PK.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A biochemically defined system for mammalian nonhomologous DNA end joining
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
SCID in Jack Russell terriers: a new animal model of DNA-PKcs deficiency
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The DNA-dependent protein kinase: the director at the end.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Subnuclear localization of Ku protein: functional association with RNA polymerase II elongation sites.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Polymerase mu is a DNA-directed DNA/RNA polymerase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential activation of DNA-PK based on DNA strand orientation and sequence bias
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA double-strand break and chromosomal rejoining defects with misrejoining in Nijmegen breakage syndrome cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation in the serine/threonine 2609-2647 cluster promotes but is not essential for DNA-dependent protein kinase-mediated nonhomologous end joining in human whole-cell extracts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A DNA end-binding factor involved in double-strand break repair and V(D)J recombination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
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A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
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Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pathways of DNA double-strand break repair during the mammalian cell cycle
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Failure of hairpin-ended and nicked DNA To activate DNA-dependent protein kinase: implications for V(D)J recombination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation and autoregulation of DNA-PK from structured single-stranded DNA and coding end hairpins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cisplatin-DNA adducts inhibit translocation of the Ku subunits of DNA-PK.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase-mediated phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-PKcs function regulated specifically by protein phosphatase 5
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The endless tale of non-homologous end-joining
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of DNA dependent protein kinase in synapsis of DNA ends.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATR-dependent phosphorylation of DNA-dependent protein kinase catalytic subunit in response to UV-induced replication stress
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
IgH class switching and translocations use a robust non-classical end-joining pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Coordinate 5' and 3' endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The DNA-dependent protein kinase catalytic activity regulates DNA end processing by means of Ku entry into DNA
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Photocross-linking of an oriented DNA repair complex. Ku bound at a single DNA end
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2900602-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0065-2776(08)00602-0
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1497682
Fatcat ID
release_365wxapmsbh7beedkeijzv45ci
0 references
OpenCitations bibliographic resource ID
1497682
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1497682
PubMed publication ID
19117531
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1497682
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