(Q28361241)

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Supracrystallographic resolution of interactions contributing to enzyme catalysis by use of natural structural variants and reactivity-probe kinetics

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scholarly article

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Europe PubMed Central

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20 September 2019

Supracrystallographic resolution of interactions contributing to enzyme catalysis by use of natural structural variants and reactivity-probe kinetics (English)

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20 September 2019

6

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20 September 2019

author name string

K Brocklehurst

1

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20 September 2019

S M Brocklehurst

2

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20 September 2019

D Kowlessur

3

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20 September 2019

M O'Driscoll

4

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20 September 2019

G Patel

5

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20 September 2019

W Templeton

7

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20 September 2019

E Thomas

8

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20 September 2019

C M Topham

9

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20 September 2019

F Willenbrock

10

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20 September 2019

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publication date

1 December 1988

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20 September 2019

number of pages

16

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Biochemical Journal

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20 September 2019

256

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20 September 2019

2

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20 September 2019

543-558

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20 September 2019

1 reference

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20 March 2017

1 reference

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20 March 2017

Thiol proteases. Comparative studies based on the high-resolution structures of papain and actinidin, and on amino acid sequence information for cathepsins B and H, and stem bromelain

1 reference

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20 March 2017

Substrate-derived two-protonic-state electrophiles as sensitive kinetic specificity probes for cysteine proteinases. Activation of 2-pyridyl disulphides by hydrogen-bonding

1 reference

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20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1135444

20 March 2017

Calculations of electrostatic interactions in biological systems and in solutions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1135444

29 September 2017

Mapping the active site of papain with the aid of peptide substrates and inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1135444

29 September 2017

Designing substrate specificity by protein engineering of electrostatic interactions

1 reference

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29 September 2017

Toward computer-aided site-directed mutagenesis of enzymes

1 reference

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29 September 2017

Knowledge based modelling of homologous proteins, Part II: Rules for the conformations of substituted sidechains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1135444

29 September 2017

Protein engineering. The design, synthesis and characterization of factitious proteins

1 reference

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29 September 2017

Tinkering with enzymes: what are we learning?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1135444

29 September 2017

18th Sir Hans Krebs lecture. Knowledge-based protein modelling and design

1 reference

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29 September 2017

Simple alkanethiol groups for temporary blocking of sulfhydryl groups of enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1135444

29 September 2017

Characterization of the papain active centre by using two-protonic-state electrophiles as reactivity probes. Evidence for nucleophilic reactivity in the un-interrupted cysteine-25-histidine-159 interactive system

1 reference

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29 September 2017

A reporter group delivery system with both absolute and selective specificity for thiol groups and an improved fluorescent probe containing the 7-nitrobenzo-2-oxa-1,3-diazole moiety

1 reference

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29 September 2017

Appendix: Analysis of pH-dependent kinetics in up to four reactive hydronic states

1 reference

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2 June 2018

Differences in the interaction of the catalytic groups of the active centres of actinidin and papain. Rapid purification of fully active actinidin by covalent chromatography and characterization of its active centre by use of two-protonic-state reac

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1135444

2 June 2018

Investigation of the catalytic site of actinidin by using benzofuroxan as a reactivity probe with selectivity for the thiolate-imidazolium ion-pair systems of cysteine proteinases. Evidence that the reaction of the ion-pair of actinidin (pKI 3.0, pK

1 reference

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2 June 2018

Effects of conformational selectivity and of overlapping kinetically influential ionizations on the characteristics of pH-dependent enzyme kinetics. Implications of free-enzyme pKa variability in reactions of papain for its catalytic mechanism.

1 reference

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2 June 2018

Kinetic specificity in papain-catalysed hydrolyses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1135444

2 June 2018

Reactions of papain and of low-molecular-weight thiols with some aromatic disulphides. 2,2'-Dipyridyl disulphide as a convenient active-site titrant for papain even in the presence of other thiols

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1135444

2 June 2018

Kinetics of papain-catalyzed hydrolysis of -N-benzoyl-L-arginine-p-nitroanilide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1135444

2 June 2018

Preparation of cathepsins B and H by covalent chromatography and characterization of their catalytic sites by reaction with a thiol-specific two-protonic-state reactivity probe. Kinetic study of cathepsins B and H extending into alkaline media and a

1 reference

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2 June 2018

Chemical evidence for the pH-dependent control of ion-pair geometry in cathepsin B. Benzofuroxan as a reactivity probe sensitive to differences in the mutual disposition of the thiolate and imidazolium components of cysteine proteinase catalytic sit

1 reference

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2 June 2018

Two-dimensional 1H-NMR studies of the solution structure of plasminogen kringle 4.

1 reference

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2 June 2018

Differences in the chemical and catalytic characteristics of two crystallographically 'identical' enzyme catalytic sites. Characterization of actinidin and papain by a combination of pH-dependent substrate catalysis kinetics and reactivity probe stu

1 reference

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2 June 2018

Protein thiolation and reversible protein-protein conjugation. N-Succinimidyl 3-(2-pyridyldithio)propionate, a new heterobifunctional reagent

1 reference

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2 June 2018

A necessary modification to the preparation of papain from any high-quality latex of Carica papaya and evidence for the structural integrity of the enzyme produced by traditional methods

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1135444

2 June 2018

Probing steric and hydrophobic effects on enzyme-substrate interactions by protein engineering.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1135444

27 November 2018

Electrostatic effects on modification of charged groups in the active site cleft of subtilisin by protein engineering

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27 November 2018

Protein engineering

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The evolution of papain

1 reference

https://pubmed.ncbi.nlm.nih.gov/3223929

12 December 2020

based on heuristic

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Redesigning trypsin: alteration of substrate specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/3223929

12 December 2020

based on heuristic

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Two-dimensional 1H NMR studies of cytochrome c

1 reference

https://pubmed.ncbi.nlm.nih.gov/3223929

12 December 2020

based on heuristic

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Chromophoric and fluorophoric peptide substrates cleaved through the dipeptidyl carboxypeptidase activity of cathepsin B

1 reference

https://pubmed.ncbi.nlm.nih.gov/3223929

12 December 2020

based on heuristic

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Knowledge based modelling of homologous proteins, Part I: Three-dimensional frameworks derived from the simultaneous superposition of multiple structures

1 reference

https://pubmed.ncbi.nlm.nih.gov/3223929

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ2560543

1 reference

Europe PubMed Central

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20 September 2019

1 reference

Europe PubMed Central

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20 September 2019

1 reference

Europe PubMed Central

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20 September 2019

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