(Q41844251)

English

Effects of conformational selectivity and of overlapping kinetically influential ionizations on the characteristics of pH-dependent enzyme kinetics. Implications of free-enzyme pKa variability in reactions of papain for its catalytic mechanism.

scientific article published on June 1983

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6309137%20AND%20SRC:MED&resulttype=core&format=json

9 October 2019

Effects of conformational selectivity and of overlapping kinetically influential ionizations on the characteristics of pH-dependent enzyme kinetics. Implications of free-enzyme pKa variability in reactions of papain for its catalytic mechanism (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6309137%20AND%20SRC:MED&resulttype=core&format=json

9 October 2019

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6309137%20AND%20SRC:MED&resulttype=core&format=json

9 October 2019

author name string

K Brocklehurst

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6309137%20AND%20SRC:MED&resulttype=core&format=json

9 October 2019

S J Willenbrock

2

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9 October 2019

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1 June 1983

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9 October 2019

number of pages

8

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Biochemical Journal

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9 October 2019

211

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9 October 2019

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6309137%20AND%20SRC:MED&resulttype=core&format=json

9 October 2019

701-708

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6309137%20AND%20SRC:MED&resulttype=core&format=json

9 October 2019

Evidence for a two-state transition in papain that may have no close analogue in ficin. Differences in the disposition of cationic sites and hydrophobic binding areas in the active centres of papain and ficin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1154417

6 June 2018

Current problems in mechanistic studies of serine and cysteine proteinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1154417

6 June 2018

Binding of chloromethyl ketone substrate analogues to crystalline papain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1154417

6 June 2018

Mechanism of the reaction of papain with substrate-derived diazomethyl ketones. Implications for the difference in site specificity of halomethyl ketones for serine proteinases and cysteine proteinases and for stereoelectronic requirements in the pa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1154417

6 June 2018

Evidence for association-activation effects in reactions of papain from studies on its reactivity towards isomeric two-protonic-state reactivity probes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1154417

6 June 2018

Mechanism of action of papain with a specific anilide substrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1154417

6 June 2018

Evidence that binding to the s2-subsite of papain may be coupled with catalytically relevant structural change involving the cysteine-25-histidine-159 diad. Kinetics of the reaction of papain with a two-protonic-state reactivity probe containing a h

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1154417

6 June 2018

Mechanism of thiol protease catalysis: detection and stabilization of a tetrahedral intermediate in papain catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1154417

6 June 2018

Identification of the Functional Ionic Groups of Papain by pH/Rate Profile Analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1154417

6 June 2018

Characterization of the papain active centre by using two-protonic-state electrophiles as reactivity probes. Evidence for nucleophilic reactivity in the un-interrupted cysteine-25-histidine-159 interactive system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1154417

6 June 2018

The pH-dependence of second-order rate constants of enzyme modification may provide free-reactant pKa values

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1154417

6 June 2018

Benzofuroxan as a thiol-specific reactivity probe. Kinetics of its reactions with papain, ficin, bromelain and low-molecular-weight thiols

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1154417

6 June 2018

4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole as a reactivity probe for the investigation of the thiol proteinases. evidence that ficin and bromelain may lack carboxyl groups conformationally equivalent to that of aspartic acid-158 of papain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1154417

6 June 2018

PH-dependence of the steady-state rate of a two-step enzymic reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1154417

6 June 2018

Evidence for a close similarity in the catalytic sites of papain and ficin in near-neutral media despite differences in acidic and alkaline media. Kinetics of the reactions of papain and ficin with chloroacetate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1154417

18 August 2018

Characterization of papaya peptidase A as a cysteine proteinase of Carica papaya L. with active-centre properties that differ from those of papain by using 2,2'-dipyridyl disulphide and 4-chloro-7-nitrobenzofurazan as reactivity probes. Use of two-p

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1154417

18 August 2018

Reaction of the Sulfhydryl Group of Papain with Chloroacetic Acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/6309137

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reaction of papain with -bromo- -(5-imidazolyl)propionic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/6309137

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-operative ionisation of aspartic-acid-158 and histidine-159 in papain. Evidence from 19F nuclear-magnetic-resonance and fluorescence spectroscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/6309137

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cryoenzymology of papain: reaction mechanism with an ester substrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/6309137

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for multiple reactive forms of papain

1 reference

https://pubmed.ncbi.nlm.nih.gov/6309137

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of cysteine-25 on the ionization of histidine-159 in papain as determined by proton nuclear magnetic resonance spectroscopy. Evidence for a his-159--Cys-25 ion pair and its possible role in catalysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/6309137

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

24 Two-protonic-state electrophiles as probes of enzyme mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/6309137

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stereospecific Alkylation with Asymmetric Reagents

1 reference

https://pubmed.ncbi.nlm.nih.gov/6309137

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reaction of chloroacetamide with the sulfhydryl group of papain

1 reference

https://pubmed.ncbi.nlm.nih.gov/6309137

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ2110701

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6309137%20AND%20SRC:MED&resulttype=core&format=json

9 October 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6309137%20AND%20SRC:MED&resulttype=core&format=json

9 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:6309137%20AND%20SRC:MED&resulttype=core&format=json

9 October 2019

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