(Q41977669)

English

Mechanism of the reaction of papain with substrate-derived diazomethyl ketones. Implications for the difference in site specificity of halomethyl ketones for serine proteinases and cysteine proteinases and for stereoelectronic requirements in the pa

scientific article published on November 1, 1978

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Mechanism of the reaction of papain with substrate-derived diazomethyl ketones. Implications for the difference in site specificity of halomethyl ketones for serine proteinases and cysteine proteinases and for stereoelectronic requirements in the pa (English)

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Mechanism of the reaction of papain with substrate-derived diazomethyl ketones. Implications for the difference in site specificity of halomethyl ketones for serine proteinases and cysteine proteinases and for stereoelectronic requirements in the papain catalytic mechanism (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A743223

24 July 2022

author name string

K. Brocklehurst

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A743223

24 July 2022

J. P. Malthouse

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A743223

24 July 2022

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publication date

1 November 1978

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

full work available at URL

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/743223/pdf/?tool=EBI

Portable Document Format

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A743223

24 July 2022

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/743223/?tool=EBI

online access status

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A743223

24 July 2022

https://europepmc.org/articles/PMC1186128

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A743223

24 July 2022

https://europepmc.org/articles/PMC1186128?pdf=render

Portable Document Format

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A743223

24 July 2022

Biochemical Journal

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

175

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

2

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

761-764

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Shapes of curves of pH-dependence of reactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1186128

5 June 2018

Mercaptide-imidazolium ion-pair: the reactive nucleophile in papain catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1186128

5 June 2018

The amidotransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1186128

5 June 2018

Binding of chloromethyl ketone substrate analogues to crystalline papain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1186128

5 June 2018

The unreliability of estimates of group dissociation constants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1186128

5 June 2018

Antiproteolytic aldehydes and ketones: substituent and secondary deuterium isotope effects on equilibrium addition of water and other nucleophiles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1186128

5 June 2018

Kinetic Isotope Effects in Enzymology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1186128

5 June 2018

The case for assigning a value of approximately 4 to pKaI of the essential histidine-cysteine interactive systems of papain, bromelain and ficin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1186128

5 June 2018

Characterization of the papain active centre by using two-protonic-state electrophiles as reactivity probes. Evidence for nucleophilic reactivity in the un-interrupted cysteine-25-histidine-159 interactive system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1186128

5 June 2018

The pH-dependence of second-order rate constants of enzyme modification may provide free-reactant pKa values

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1186128

5 June 2018

Benzofuroxan as a thiol-specific reactivity probe. Kinetics of its reactions with papain, ficin, bromelain and low-molecular-weight thiols

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1186128

5 June 2018

Preparation of fully active ficin from Ficus glabrata by covalent chromatography and characterization of its active centre by using 2,2'-depyridyl disulphide as a reactivity probe

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1186128

5 June 2018

Rate of Liberation of Acid by betabeta'-Dichlorodiethyl Sulphide and its Analogues in its Relation to the "Acid" Theory of Skin Vesication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1186128

18 August 2018

Diazomethyl ketone substrate derivatives as active-site-directed inhibitors of thiol proteases. Papain

1 reference

https://pubmed.ncbi.nlm.nih.gov/743223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The importance of the conformation of the tetrahedral intermediate for the α‐chymotrypsin‐catalyzed hydrolysis of peptide substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/743223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the mode of activation of the catalytically essential sulfhydryl group of papain

1 reference

https://pubmed.ncbi.nlm.nih.gov/743223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polypeptide halomethyl ketones bind to serine proteases as analogs of the tetrahedral intermediate. X-ray crystallographic comparison of lysine- and phenylalanine-polypeptide chloromethyl ketone-inhibited subtilisin

1 reference

https://pubmed.ncbi.nlm.nih.gov/743223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reaction of chloroacetamide with the sulfhydryl group of papain

1 reference

https://pubmed.ncbi.nlm.nih.gov/743223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical modification of papain. I. Reaction with the chloromethyl ketones of phenylalanine and lysine and with phenylmethyl-sulfonyl fluoride

1 reference

https://pubmed.ncbi.nlm.nih.gov/743223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stereospecific Alkylation with Asymmetric Reagents

1 reference

https://pubmed.ncbi.nlm.nih.gov/743223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Preparation and Properties of trans-Cinnamoyl-Papain1

1 reference

https://pubmed.ncbi.nlm.nih.gov/743223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The formation of anhydrochymotrypsin by removing the elements of water from the serine at the active site

1 reference

https://pubmed.ncbi.nlm.nih.gov/743223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Reaction of Carbanions with N,S-Diacetylcysteamine. A Model for Enzymatic Carbon-Carbon Condensation1

1 reference

https://pubmed.ncbi.nlm.nih.gov/743223

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ1750761

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

ResearchGate publication ID

0 references

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