(Q28365414)

English

Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo

scientific article

In more languages

Statements

scholarly article

0 references

Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo (English)

0 references

stereoselectivity

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

object named as

F Corbo

7

0 references

Giovanni Lentini

object named as

G Lentini

5

0 references

Carlo Franchini

object named as

C Franchini

8

0 references

Annamaria De Luca

1 reference

ORCID Public Data File 2021

Diana Conte Camerino

11

object named as

D Conte Camerino

0 references

author name string

S Talon

1

0 references

A De Luca

2

0 references

M De Bellis

3

0 references

J F Desaphy

4

0 references

A Scilimati

6

0 references

P Tortorella

9

0 references

H Jockusch

10

0 references

language of work or name

0 references

publication date

December 2001

0 references

British Journal of Pharmacology

0 references

134

0 references

7

0 references

1523-31

0 references

Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

20 March 2017

Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na(+) channels with increased potency and improved use-dependent activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

29 September 2017

Residues in Na(+) channel D3-S6 segment modulate both batrachotoxin and local anesthetic affinities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

29 September 2017

Ion channel genes and human neurological disease: recent progress, prospects, and challenges.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

29 September 2017

Evaluation of the antimyotonic activity of mexiletine and some new analogs on sodium currents of single muscle fibers and on the abnormal excitability of the myotonic ADR mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

29 September 2017

Molecular pathophysiology of voltage-gated ion channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

29 September 2017

Ion-channel defects and aberrant excitability in myotonia and periodic paralysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

29 September 2017

Drug therapy. Tocainide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

29 September 2017

An improved vaseline gap voltage clamp for skeletal muscle fibers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

29 September 2017

Increased hindrance on the chiral carbon atom of mexiletine enhances the block of rat skeletal muscle Na+ channels in a model of myotonia induced by ATX

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

2 June 2018

Lysine point mutations in Na+ channel D4-S6 reduce inactivated channel block by local anesthetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

2 June 2018

From mutation to myotonia in sodium channel disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

2 June 2018

Molecular determinants of state-dependent block of Na+ channels by local anesthetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

2 June 2018

Successful treatment with tocainide of recessive generalized congenital myotonia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

2 June 2018

Inactivation of human sodium channels and the effect of tocainide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

2 June 2018

Tocainide therapy in muscle cramps and spasms due to neuromuscular disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

2 June 2018

The different use dependences of tocainide and benzocaine are correlated with different effects on sodium channel inactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

2 June 2018

Stereoselective interaction of tocainide and its chiral analogs with the sodium channels in human myoballs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

2 June 2018

Synthesis of Mexiletine Stereoisomers and Related Compounds via S(N)Ar Nucleophilic Substitution of a Cr(CO)(3)-Complexed Aromatic Fluoride

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

27 November 2018

Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

27 November 2018

Point mutations at N434 in D1-S6 of mu1 Na(+) channels modulate binding affinity and stereoselectivity of local anesthetic enantiomers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

27 November 2018

A molecular basis for the different local anesthetic affinities of resting versus open and inactivated states of the sodium channel.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

27 November 2018

The familial periodic paralyses and nondystrophic myotonias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

27 November 2018

Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

27 November 2018

Nonsense and missense mutations in the muscular chloride channel gene Clc-1 of myotonic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1573071

27 November 2018

Molecular determinants of mexiletine structure for potent and use-dependent block of skeletal muscle sodium channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/11724759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the repetitive discharge in myotonic muscle fibres

1 reference

https://pubmed.ncbi.nlm.nih.gov/11724759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of myotonia with antiarrhythmic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/11724759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stereoselective effects of mexiletine enantiomers on sodium currents and excitability characteristics of adult skeletal muscle fibers

1 reference

https://pubmed.ncbi.nlm.nih.gov/11724759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antimyotonic effects of tocainide enantiomers on skeletal muscle fibers of congenitally myotonic goats

1 reference

https://pubmed.ncbi.nlm.nih.gov/11724759

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Action potentials reconstructed in normal and myotonic muscle fibres

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0704366

7 January 2021

based on heuristic

inferred from DOI database lookup

Development and use of quantum mechanical molecular models. 76. AM1: a new general purpose quantum mechanical molecular model

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0704366

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.BJP.0704366

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q28365414&oldid=1741988527"