(Q28377503)

English

Rapid and highly sensitive method for the determination of verapamil, [2H7]verapamil and metabolites in biological fluids by liquid chromatography-mass spectrometry

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scholarly article

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Rapid and highly sensitive method for the determination of verapamil, [2H7]verapamil and metabolites in biological fluids by liquid chromatography-mass spectrometry (English)

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author name string

O von Richter

1

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M Eichelbaum

2

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F Schönberger

3

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U Hofmann

4

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language of work or name

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publication date

28 January 2000

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Journal of Chromatography B: Biomedical Sciences and Applications

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738

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1

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137-47

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describes a project that uses

liquid chromatography–mass spectrometry

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Inter- and intra-subject variation in the first-pass elimination of highly cleared drugs during chronic dosing. Studies with deuterated verapamil

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https://api.crossref.org/works/10.1016%2FS0378-4347%2899%2900508-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans

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https://api.crossref.org/works/10.1016%2FS0378-4347%2899%2900508-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil

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https://api.crossref.org/works/10.1016%2FS0378-4347%2899%2900508-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Small Intestinal Cytochromes P450

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https://api.crossref.org/works/10.1016%2FS0378-4347%2899%2900508-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin

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https://api.crossref.org/works/10.1016%2FS0378-4347%2899%2900508-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Bioavailability of imipramine tablets relative to a stable isotope-labeled internal standard: Increasing the power of bioavailability tests

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https://api.crossref.org/works/10.1016%2FS0378-4347%2899%2900508-3

7 January 2021

based on heuristic

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Stable isotopes in clinical pharmacokinetic investigations. Advantages and disadvantages

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https://api.crossref.org/works/10.1016%2FS0378-4347%2899%2900508-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Superiority of stable isotope techniques in the assessment of the bioavailability of drugs undergoing extensive first pass elimination. Studies of the relative bioavailability of verapamil tablets

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https://api.crossref.org/works/10.1016%2FS0378-4347%2899%2900508-3

7 January 2021

based on heuristic

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Jejunal absorption and metabolism of R/S-verapamil in humans

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https://api.crossref.org/works/10.1016%2FS0378-4347%2899%2900508-3

7 January 2021

based on heuristic

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Human intestinal permeability

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https://api.crossref.org/works/10.1016%2FS0378-4347%2899%2900508-3

7 January 2021

based on heuristic

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Simultaneous determination of verapamil and norverapamil in biological samples by high-performance liquid chromatography using ultraviolet detection

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https://api.crossref.org/works/10.1016%2FS0378-4347%2899%2900508-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Determination of gallopamil in serum by gas chromatography-mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4347%2899%2900508-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Determination of verapamil and norverapamil in human plasma by liquid chromatography: comparison between a liquid-liquid extraction procedure and an automated liquid-solid extraction method for sample preparation

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4347%2899%2900508-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Determination of verapamil and its primary metabolites in serum by ion-pair adsorption high-performance liquid chromatography

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4347%2899%2900508-3

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of P450 enzymes involved in metabolism of verapamil in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0378-4347%2899%2900508-3

7 January 2021

based on heuristic

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Identifiers

10.1016/S0378-4347(99)00508-3

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release_falprlcyqndbdgrkdj7f5cshie

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