(Q28384271)

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Mechanisms of Nrf2/Keap1-dependent phase II cytoprotective and detoxifying gene expression and potential cellular targets of chemopreventive isothiocyanates

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scholarly article

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10 references

25 June 2019

20 August 2019

8 September 2019

8 November 2019

20 November 2019

11 December 2019

22 December 2019

11 December 2020

23 January 2021

29 April 2021

Mechanisms of Nrf2/Keap1-dependent phase II cytoprotective and detoxifying gene expression and potential cellular targets of chemopreventive isothiocyanates (English)

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physiological phenomenon

1 reference

20 August 2019

regulation of gene expression

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8 September 2019

isocyanate ester

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8 November 2019

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20 November 2019

DNA-binding protein

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11 December 2019

transcription factor

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22 December 2019

chemoprophylaxis

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11 December 2020

intracellular signaling peptides and proteins

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23 January 2021

nuclear factor erythroid 2-related factor 2

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29 April 2021

author name string

Biswa Nath Das

1

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Young-Woo Kim

2

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Young-Sam Keum

3

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language of work or name

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publication date

28 May 2013

10 references

25 June 2019

20 August 2019

8 September 2019

8 November 2019

20 November 2019

11 December 2019

22 December 2019

11 December 2020

23 January 2021

29 April 2021

Oxidative medicine and cellular longevity

11 references

25 June 2019

20 August 2019

8 September 2019

8 November 2019

20 November 2019

11 December 2019

22 December 2019

11 December 2020

23 January 2021

29 April 2021

2013

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839409

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copyright license

Creative Commons Attribution 3.0 Unported

10 references

Europe PubMed Central

25 June 2019

Europe PubMed Central

20 August 2019

Europe PubMed Central

8 September 2019

Europe PubMed Central

8 November 2019

Europe PubMed Central

20 November 2019

Europe PubMed Central

11 December 2019

Europe PubMed Central

22 December 2019

Europe PubMed Central

11 December 2020

Europe PubMed Central

23 January 2021

Europe PubMed Central

29 April 2021

copyright status

0 references

The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

20 March 2017

NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

20 March 2017

Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

20 March 2017

The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

20 March 2017

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

20 March 2017

Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

20 March 2017

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

20 March 2017

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

20 March 2017

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

20 March 2017

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

20 March 2017

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

7 April 2017

Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

7 April 2017

Glucosinolates and isothiocyanates in health and disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Analysis and functional prediction of reactive cysteine residues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

The molecular basis that unifies the metabolism, cellular uptake and chemopreventive activities of dietary isothiocyanates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Identification of potential protein targets of isothiocyanates by proteomics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Proteins as binding targets of isothiocyanates in cancer prevention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Proteomic identification of binding targets of isothiocyanates: A perspective on techniques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Chemistry of the cysteine sensors in Kelch-like ECH-associated protein 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Nrf2: friend or foe for chemoprevention?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Molecular mechanisms of Nrf2-mediated antioxidant response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Phosphorylation of tyrosine 568 controls nuclear export of Nrf2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Chemopreventive functions of isothiocyanates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Nrf2 Possesses a redox-insensitive nuclear export signal overlapping with the leucine zipper motif.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Cancer-preventive isothiocyanates: dichotomous modulators of oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Chemoprevention by isothiocyanates and their underlying molecular signaling mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

The chemical diversity and distribution of glucosinolates and isothiocyanates among plants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Signal transduction events elicited by natural products: role of MAPK and caspase pathways in homeostatic response and induction of apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

29 September 2017

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3679808

2 June 2018

Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals

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https://api.crossref.org/works/10.1155%2F2013%2F839409

21 January 2018

Involvement of Nrf2 and JNK1 in the activation of antioxidant responsive element (ARE) by chemopreventive agent phenethyl isothiocyanate (PEITC)

1 reference

https://api.crossref.org/works/10.1155%2F2013%2F839409

21 January 2018

ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.

1 reference

https://api.crossref.org/works/10.1155%2F2013%2F839409

21 January 2018

Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3.

1 reference

https://api.crossref.org/works/10.1155%2F2013%2F839409

21 January 2018

Relationship between the occurrence of cysteine in proteins and the complexity of organisms

1 reference

https://api.crossref.org/works/10.1155%2F2013%2F839409

21 January 2018

Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain.

1 reference

https://api.crossref.org/works/10.1155%2F2013%2F839409

21 January 2018

The NRF2-related interactome and regulome contain multifunctional proteins and fine-tuned autoregulatory loops.

1 reference

https://api.crossref.org/works/10.1155%2F2013%2F839409

21 January 2018

The Keap1-Nrf2 system as an in vivo sensor for electrophiles

1 reference

https://pubmed.ncbi.nlm.nih.gov/23781297

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear factor-E2 (Nrf2) is regulated through the differential activation of ERK1/2 and PKC α/βII by Gymnasterkoreayne B

1 reference

https://pubmed.ncbi.nlm.nih.gov/23781297

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1155/2013/839409

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