(Q28394059)

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Ginsenoside compound K sensitizes human colon cancer cells to TRAIL-induced apoptosis via autophagy-dependent and -independent DR5 upregulation

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Ginsenoside compound K sensitizes human colon cancer cells to TRAIL-induced apoptosis via autophagy-dependent and -independent DR5 upregulation (English)

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1 reference

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inferred from title

author name string

Lei Chen

1

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Yue Meng

2

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Qi Sun

3

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Zhongyu Zhang

4

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Xiaoqing Guo

5

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Xiaotong Sheng

6

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Guihua Tai

7

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Hairong Cheng

8

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Yifa Zhou

9

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language of work or name

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publication date

11 August 2016

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Cell Death and Disease

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7

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8

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e2334

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copyright license

Creative Commons Attribution 4.0 International

1 August 2016

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April 2022 Public Data File from Crossref

copyright status

0 references

Trailing TRAIL Resistance: Novel Targets for TRAIL Sensitization in Cancer Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5108320

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TRAIL and proteasome inhibitors combination induces a robust apoptosis in human malignant pleural mesothelioma cells through Mcl-1 and Akt protein cleavages

1 reference

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19 March 2017

Following a TRAIL: update on a ligand and its five receptors

1 reference

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Ginseng pharmacology: multiple constituents and multiple actions

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19 March 2017

https://api.crossref.org/works/10.1038/CDDIS.2016.234

22 April 2017

Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway

1 reference

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19 March 2017

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

1 reference

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An antagonist decoy receptor and a death domain-containing receptor for TRAIL

1 reference

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19 March 2017

The receptor for the cytotoxic ligand TRAIL

1 reference

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19 March 2017

Identification and characterization of a new member of the TNF family that induces apoptosis

1 reference

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19 March 2017

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

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7 April 2017

Pharmacokinetics of ginsenoside Rb1 and its metabolite compound K after oral administration of Korean Red Ginseng extract

1 reference

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29 September 2017

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Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5.

1 reference

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29 September 2017

A ginseng metabolite, compound K, induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells

1 reference

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29 September 2017

Sensitization of TRAIL-induced cell death by 20(S)-ginsenoside Rg3 via CHOP-mediated DR5 upregulation in human hepatocellular carcinoma cells

1 reference

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29 September 2017

Mitomycin C potentiates TRAIL-induced apoptosis through p53-independent upregulation of death receptors: evidence for the role of c-Jun N-terminal kinase activation.

1 reference

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29 September 2017

CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells

1 reference

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Modulation of CCAAT/enhancer binding protein homologous protein (CHOP)-dependent DR5 expression by nelfinavir sensitizes glioblastoma multiforme cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).

1 reference

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Off-target lapatinib activity sensitizes colon cancer cells through TRAIL death receptor up-regulation

1 reference

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29 September 2017

Compound K, a metabolite of ginseng saponin, induces mitochondria-dependent and caspase-dependent apoptosis via the generation of reactive oxygen species in human colon cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5108320

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ROS and CHOP are critical for dibenzylideneacetone to sensitize tumor cells to TRAIL through induction of death receptors and downregulation of cell survival proteins

1 reference

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29 September 2017

Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5108320

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Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors

1 reference

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Immunogenic cell death, DAMPs and anticancer therapeutics: an emerging amalgamation

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29 September 2017

Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species.

1 reference

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29 September 2017

Effect of compound K, a metabolite of ginseng saponin, combined with gamma-ray radiation in human lung cancer cells in vitro and in vivo

1 reference

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29 September 2017

Enhancement of tumor-TRAIL susceptibility by modulation of autophagy

1 reference

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29 September 2017

Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL.

1 reference

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29 September 2017

Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5.

1 reference

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Tunicamycin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human prostate cancer cells

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Proteasome inhibitor MG132 induces death receptor 5 through CCAAT/enhancer-binding protein homologous protein

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Death induction by recombinant native TRAIL and its prevention by a caspase 9 inhibitor in primary human esophageal epithelial cells

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29 September 2017

Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for resistance to TRAIL-induced apoptosis.

1 reference

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29 September 2017

Safety and antitumor activity of recombinant soluble Apo2 ligand

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29 September 2017

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

1 reference

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29 September 2017

A phase 1 study of mapatumumab (fully human monoclonal antibody to TRAIL-R1) in patients with advanced solid malignancies.

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https://api.crossref.org/works/10.1038%2FCDDIS.2016.234

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Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FCDDIS.2016.234

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The role of NF-kappa B in TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis of melanoma cells

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Ginseng saponin metabolite induces apoptosis in MCF-7 breast cancer cells through the modulation of AMP-activated protein kinase.

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https://api.crossref.org/works/10.1038%2FCDDIS.2016.234

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Phase 1 and Pharmacokinetic Study of Lexatumumab in Patients with Advanced Cancers

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Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-kappaB

1 reference

https://pubmed.ncbi.nlm.nih.gov/27512955

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Bcl-XL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27512955

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inferred from PubMed ID database lookup

Ginseng intestinal bacterial metabolite IH901 as a new anti-metastatic agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/27512955

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Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27512955

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based on heuristic

inferred from PubMed ID database lookup

p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/27512955

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inferred from PubMed ID database lookup

A phase I safety and pharmacokinetic study of the death receptor 5 agonistic antibody PRO95780 in patients with advanced malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/27512955

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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