(Q28475093)

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Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20711428%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20711428%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

6

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20711428%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

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Laurent Meijer

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20711428%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

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Bénédicte Menn

1

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10 February 2020

Stéphane Bach

2

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10 February 2020

Teri L Blevins

3

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10 February 2020

Mark Campbell

4

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10 February 2020

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12 August 2010

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10 February 2020

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20711428%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

5

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20711428%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

8

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20711428%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

e12117

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20711428%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

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Creative Commons Attribution 4.0 International

12 August 2010

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April 2022 Public Data File from Crossref

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describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2920814/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Neuroprotection for ischemic stroke: past, present and future

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920814

19 March 2017

Neurotoxicity induces cleavage of p35 to p25 by calpain

1 reference

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19 March 2017

Focal Cerebral Ischaemia in the Rat: 1. Description of Technique and Early Neuropathological Consequences following Middle Cerebral Artery Occlusion

1 reference

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19 March 2017

Reversible middle cerebral artery occlusion without craniectomy in rats

1 reference

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19 March 2017

Roscovitine targets, protein kinases and pyridoxal kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920814

19 March 2017

Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920814

19 March 2017

Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920814

19 March 2017

Update of the stroke therapy academic industry roundtable preclinical recommendations

1 reference

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7 April 2017

1,026 experimental treatments in acute stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920814

7 April 2017

Pharmacologic interventions for stroke: looking beyond the thrombolysis time window into the penumbra with biomarkers, not a stopwatch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920814

29 September 2017

Cell cycle inhibition attenuates microglial proliferation and production of IL-1beta, MIP-1alpha, and NO after focal cerebral ischemia in the rat.

1 reference

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29 September 2017

Drug therapies for stroke and traumatic brain injury often display U-shaped dose responses: occurrence, mechanisms, and clinical implications

1 reference

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29 September 2017

Roscovitine reduces neuronal loss, glial activation, and neurologic deficits after brain trauma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920814

29 September 2017

Cerebral ischemia, cell cycle elements and Cdk5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920814

29 September 2017

Neuroprotection: challenges and opportunities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920814

29 September 2017

Role of cell cycle proteins in CNS injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920814

29 September 2017

Experimental treatments for acute ischaemic stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920814

29 September 2017

Cell cycle machinery and stroke.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920814

29 September 2017

Synaptic roles of Cdk5: implications in higher cognitive functions and neurodegenerative diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920814

29 September 2017

Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick Type C mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920814

29 September 2017

Oxidative neuronal injury. The dark side of ERK1/2.

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29 September 2017

Solubilizing excipients in oral and injectable formulations

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29 September 2017

Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920814

29 September 2017

Pharmacological inhibitors of cyclin-dependent kinases

1 reference

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29 September 2017

Salvaging the ischaemic penumbra: more than just reperfusion?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920814

29 September 2017

A decade of CDK5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920814

29 September 2017

Cyclin-dependent kinases as a therapeutic target for stroke.

1 reference

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29 September 2017

Recommendations for standards regarding preclinical neuroprotective and restorative drug development

1 reference

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29 September 2017

Cell cycle protein expression in proliferating microglia and astrocytes following transient global cerebral ischemia in the rat

1 reference

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21 January 2018

Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: a modulator of in vivo programmed cell death?

1 reference

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21 January 2018

Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012117

21 January 2018

Age-dependent pharmacokinetics and effect of roscovitine on Cdk5 and Erk1/2 in the rat brain.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012117

21 January 2018

Tissue distribution, pharmacokinetics and identification of roscovitine metabolites in rat.

1 reference

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21 January 2018

Recruitment of several neuroprotective pathways after permanent focal ischemia in mice

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012117

21 January 2018

Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives

1 reference

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21 January 2018

Cell cycle inhibition and retinoblastoma protein overexpression prevent Purkinje cell death in organotypic slice cultures

1 reference

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21 January 2018

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012117

21 January 2018

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

1 reference

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Seliciclib in malignancies

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Efficient transfection of DNA or shRNA vectors into neurons using magnetofection

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21 January 2018

Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death.

1 reference

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27 November 2018

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27 November 2018

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Unscheduled re-entry into the cell cycle induced by NGF precedes cell death in nascent retinal neurones

1 reference

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12 December 2020

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10.1371/JOURNAL.PONE.0012117

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20711428%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

2010PLoSO...512117M

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20711428%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

PubMed publication ID

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20711428%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

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