(Q28475942)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21060682%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

title

Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21060682%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

1 reference

9

1 reference

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16 January 2020

author name string

Pooja P Pungaliya

1

1 reference

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16 January 2020

Yuchen Bai

2

1 reference

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16 January 2020

Kerri Lipinski

3

1 reference

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16 January 2020

Vasanti S Anand

4

1 reference

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16 January 2020

Saurabh Sen

5

1 reference

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16 January 2020

Eugene L Brown

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21060682%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Brian Bates

7

1 reference

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16 January 2020

Peter H Reinhart

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21060682%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Warren D Hirst

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21060682%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

Steven P Braithwaite

11

1 reference

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16 January 2020

language of work or name

English

0 references

publication date

27 October 2010

1 reference

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16 January 2020

1 reference

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16 January 2020

volume

5

1 reference

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16 January 2020

issue

10

1 reference

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16 January 2020

page(s)

e13672

1 reference

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Creative Commons Attribution 4.0 International

16 January 2020

copyright license

start time

27 October 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

1 reference

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Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment

19 March 2017

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Structure of ERA in complex with the 3' end of 16S rRNA: Implications for ribosome biogenesis

19 March 2017

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LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

19 March 2017

1 reference

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The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration

19 March 2017

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A quantitative atlas of mitotic phosphorylation

19 March 2017

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LRRK2 regulates synaptic vesicle endocytosis

19 March 2017

1 reference

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The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

19 March 2017

1 reference

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Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

19 March 2017

1 reference

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Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

19 March 2017

1 reference

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siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy

19 March 2017

1 reference

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The R1441C mutation of LRRK2 disrupts GTP hydrolysis

19 March 2017

1 reference

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GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

19 March 2017

1 reference

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Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

19 March 2017

1 reference

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The familial Parkinsonism gene LRRK2 regulates neurite process morphology

19 March 2017

1 reference

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Kinase activity of mutant LRRK2 mediates neuronal toxicity

19 March 2017

1 reference

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LRRK2 in Parkinson's disease: protein domains and functional insights

19 March 2017

1 reference

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The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

19 March 2017

1 reference

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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

19 March 2017

1 reference

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The MAP2/Tau family of microtubule-associated proteins

19 March 2017

1 reference

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

19 March 2017

1 reference

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WebLogo: A Sequence Logo Generator

19 March 2017

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Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs

19 March 2017

1 reference

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The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum

19 March 2017

1 reference

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PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain

19 March 2017

1 reference

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A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1

19 March 2017

1 reference

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Sequence logos: a new way to display consensus sequences

19 March 2017

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Praja1, a novel gene encoding a RING-H2 motif in mouse development

19 March 2017

1 reference

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Ras oncogenes: split personalities

19 March 2017

1 reference

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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

7 April 2017

1 reference

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Use of an oriented peptide library to determine the optimal substrates of protein kinases

7 April 2017

1 reference

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Cell cycle checkpoint signaling through the ATM and ATR kinases

7 April 2017

1 reference

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GTPase activity plays a key role in the pathobiology of LRRK2.

7 April 2017

1 reference

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Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications

29 September 2017

1 reference

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The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Identification of the autophosphorylation sites of LRRK2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Mapping the phosphorylation sites of Ulk1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

All-you-can-eat: autophagy in neurodegeneration and neuroprotection.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Genes associated with Parkinson syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Update on the pathogenesis of Parkinson's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

G protein-coupled receptor-promoted trafficking of Gbeta1gamma2 leads to AKT activation at endosomes via a mechanism mediated by Gbeta1gamma2-Rab11a interaction

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Mutations in LRRK2 as a cause of Parkinson's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

The age of crosstalk: phosphorylation, ubiquitination, and beyond

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Determining protein kinase substrate specificity by parallel solution-phase assay of large numbers of peptide substrates

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Both postsynaptic and presynaptic dysfunction contribute to Parkinson disease: any mechanism will not do.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Rapid purification of native dynamin I and colorimetric GTPase assay

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Molecular pathophysiology of Parkinson's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

A rapid method for determining protein kinase phosphorylation specificity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Kinase peptide specificity: improved determination and relevance to protein phosphorylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

MAP2c, but not tau, binds and bundles F-actin via its microtubule binding domain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

The archaeon Sulfolobus solfataricus contains a membrane-associated protein kinase activity that preferentially phosphorylates threonine residues in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Utilization of oriented peptide libraries to identify substrate motifs selected by ATM.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Phosphorylation of microtubule-associated protein 2 (MAP2) and its relevance for the regulation of the neuronal cytoskeleton function.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Molecular pathogenesis of movement disorders: are protein aggregates a common link in neuronal degeneration?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Biochemical and biological properties of the human N-ras p21 protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Comparative biochemical properties of normal and activated human ras p21 protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.

2 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0013672

Detection of protein tyrosine kinase activity using a high-capacity streptavidin-coated membrane and optimized biotinylated peptide substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0013672

Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0013672

Kinetic mechanistic studies of wild-type leucine-rich repeat kinase 2: characterization of the kinase and GTPase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0013672

Supervised detection of conserved motifs in DNA sequences with cosmo

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965117

10.1371/JOURNAL.PONE.0013672

27 November 2018

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1364126

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21060682%20AND%20SRC:MED&resulttype=core&format=json

OpenCitations bibliographic resource ID

16 January 2020

ADS bibcode

2010PLoSO...513672P

0 references

1364126

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21060682%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

PubMed publication ID

21060682

1 reference