(Q28476505)

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An integrated Drosophila model system reveals unique properties for F14512, a novel polyamine-containing anticancer drug that targets topoisomerase II

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An integrated Drosophila model system reveals unique properties for F14512, a novel polyamine-containing anticancer drug that targets topoisomerase II (English)

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Emmanuel Käs

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author name string

Sonia Chelouah

1

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Caroline Monod-Wissler

2

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Christian Bailly

3

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Jean-Marc Barret

4

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Nicolas Guilbaud

5

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Stéphane Vispé

6

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2011

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6

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8

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e23597

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Creative Commons Attribution 4.0 International

10 August 2011

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April 2022 Public Data File from Crossref

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DNA topoisomerases and their poisoning by anticancer and antibacterial drugs

1 reference

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19 March 2017

Targeting DNA topoisomerase II in cancer chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

19 March 2017

Cellular roles of dna topoisomerases: a molecular perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

19 March 2017

Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

19 March 2017

Wnt3a links left-right determination with segmentation and anteroposterior axis elongation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

19 March 2017

Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

19 March 2017

Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Preclinical activity of F14512, designed to target tumors expressing an active polyamine transport system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Type II topoisomerases--inhibitors, repair mechanisms and mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

A Drosophila model identifies calpains as modulators of the human leukemogenic fusion protein AML1-ETO

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Recent advances in the development of polyamine analogues as antitumor agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Topoisomerase II{alpha}-dependent and -independent apoptotic effects of dexrazoxane and doxorubicin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

DNA topoisomerase II and its growing repertoire of biological functions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Topoisomerase II inhibition involves characteristic chromosomal expression patterns

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Apoptosis is the most efficient death-pathway in tumor cells after topoisomerase II inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

HP1: a functionally multifaceted protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Chromatin structure and the regulation of gene expression: the lessons of PEV in Drosophila

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

A Drosophila model to identify polyamine-drug conjugates that target the polyamine transporter in an intact epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

The Release 5.1 annotation of Drosophila melanogaster heterochromatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Eye development under the control of SRp55/B52-mediated alternative splicing of eyeless

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Induction of ATM activation, histone H2AX phosphorylation and apoptosis by etoposide: relation to cell cycle phase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Cellular response to etoposide treatment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Displacement of D1, HP1 and topoisomerase II from satellite heterochromatin by a specific polyamide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Variegation in Drosophila and the Inert Chromosome Regions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

The contradictory definitions of heterochromatin: transcription and silencing.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

In vivo synergy between topoisomerase II and histone deacetylase inhibitors: predictive correlates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Target practice: aiming at satellite repeats with DNA minor groove binders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Ornithine decarboxylase gene is overexpressed in colorectal carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

From DNA damage to G2 arrest: the many roles of topoisomerase II

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Thirty Years of Polyamine-Related Approaches to Cancer Therapy. Retrospect and Prospect. Part 1. Selective Enzyme Inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Apoptosis induced by topoisomerase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

The AT-hook protein D1 is essential for Drosophila melanogaster development and is implicated in position-effect variegation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Tumor cell death induced by topoisomerase-targeting drugs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces differentiation and apoptosis in human leukemia K562 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Molecular basis for the inhibition of Drosophila eye development by Antennapedia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

DNA topoisomerase II as the target for the anticancer drug TOP-53: mechanistic basis for drug action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

The fourth chromosome of Drosophila melanogaster: interspersed euchromatic and heterochromatic domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Resistance mechanisms associated with altered intracellular distribution of anticancer agents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Genomic sites of topoisomerase II activity determined by comparing DNA breakage enhanced by three distinct poisons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Polyamine transport in mammalian cells. An update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Drug-specific sites of topoisomerase II DNA cleavage in Drosophila chromatin: heterogeneous localization and reversibility.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Mutations of zeste that mediate transvection are recessive enhancers of position-effect variegation in Drosophila melanogaster

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

A model for chromatin opening: stimulation of topoisomerase II and restriction enzyme cleavage of chromatin by distamycin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Apoptosis induced by DNA topoisomerase I and II inhibitors in human leukemic HL-60 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Identification of Polycomb and trithorax group responsive elements in the regulatory region of the Drosophila homeotic gene Sex combs reduced

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Organization of the higher-order chromatin loop: specific DNA attachment sites on nuclear scaffold

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Preferential, cooperative binding of DNA topoisomerase II to scaffold-associated regions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

DNA topoisomerase poisons as antitumor drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Mammalian topoisomerase II activity is modulated by the DNA minor groove binder distamycin in simian virus 40 DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Chromatin structure, not DNA sequence specificity, is the primary determinant of topoisomerase II sites of action in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Scaffold-associated regions: cis-acting determinants of chromatin structural loops and functional domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

In vivo topoisomerase II cleavage of the Drosophila histone and satellite III repeats: DNA sequence and structural characteristics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

29 September 2017

Drosophila chromosome condensation proteins Topoisomerase II and Barren colocalize with Polycomb and maintain Fab-7 PRE silencing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

2 June 2018

Structure of the Drosophila DNA topoisomerase II gene. Nucleotide sequence and homology among topoisomerases II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

2 June 2018

Chromosome assembly in vitro: Topoisomerase II is required for condensation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

2 June 2018

Relationships between DNA strand breakage and apoptotic progression upon treatment of HL-60 leukemia cells with tafluposide or etoposide.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023597

21 January 2018

Gene expression of ornithine decarboxylase in lung cancers and its clinical significance

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023597

21 January 2018

Ornithine decarboxylase (ODC) expression pattern in human prostate tissues and ODC transgenic mice.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023597

21 January 2018

Types of visible variations induced by X-rays inDrosophila

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023597

21 January 2018

The doxorubicin cardioprotective agent dexrazoxane (ICRF-187) induces endopolyploidy in rat neonatal myocytes through inhibition of DNA topoisomerase II.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023597

21 January 2018

Carnitine suppression of position-effect variegation in Drosophila melanogaster.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023597

21 January 2018

Specific gain- and loss-of-function phenotypes induced by satellite-specific DNA-binding drugs fed to Drosophila melanogaster.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023597

21 January 2018

Butyrate sensitive suppressor of position-effect variegation mutations in Drosophila melanogaster.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0023597

21 January 2018

Etoposide induces G2/M arrest and apoptosis in neural progenitor cells via DNA damage and an ATM/p53-related pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154508

27 November 2018

Cellular resistance to topoisomerase-targeted drugs: from drug uptake to cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of ornithine decarboxylase messenger RNA in human esophageal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resolving the role of topoisomerase II in chromatin structure and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Butyrate suppression of position-effect variegation in Drosophila melanogaster

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Poisons of DNA topoisomerases I and II]

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity of a novel podophyllotoxin derivative (TOP-53) against lung cancer and lung metastatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21853156

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0023597

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2011PLoSO...623597C

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