(Q28480422)

English

Small molecules with similar structures exhibit agonist, neutral antagonist or inverse agonist activity toward angiotensin II type 1 receptor

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scholarly article

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Small molecules with similar structures exhibit agonist, neutral antagonist or inverse agonist activity toward angiotensin II type 1 receptor (English)

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10

object named as

Issei Komuro

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Hiroaki Yanagisawa

8

object named as

Hiroaki Yanagisawa

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4

object named as

Naoki Nakao

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Masahiro Fujino

5

object named as

Masahiro Fujino

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Shin-ichiro Miura

1

object named as

Shin-ichiro Miura

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2

object named as

Yoshihiro Kiya

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7

object named as

Yoshino Matsuo

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author name string

Hiroyuki Hanzawa

3

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Satoshi Imaizumi

6

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Hiroyuki Koike

9

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Sadashiva S Karnik

11

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Keijiro Saku

12

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language of work or name

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publication date

2012

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7

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6

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e37974

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copyright license

Creative Commons Attribution 4.0 International

14 June 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

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Two distinct conformations of helix 6 observed in antagonist-bound structures of a 1-adrenergic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

19 March 2017

The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

19 March 2017

Structure and function of an irreversible agonist-β(2) adrenoceptor complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

19 March 2017

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

19 March 2017

Crystal structure of opsin in its G-protein-interacting conformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

19 March 2017

Crystal structure of the ligand-free G-protein-coupled receptor opsin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

19 March 2017

Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

19 March 2017

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

19 March 2017

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

19 March 2017

Differential bonding interactions of inverse agonists of angiotensin II type 1 receptor in stabilizing the inactive state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

19 March 2017

International union of pharmacology. XXIII. The angiotensin II receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

19 March 2017

Crystal structure of rhodopsin: A G protein-coupled receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

19 March 2017

TM2-TM7 interaction in coupling movement of transmembrane helices to activation of the angiotensin II type-1 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

19 March 2017

Structural requirements for inverse agonism and neutral antagonism of indole-, benzimidazole-, and thienopyrrole-derived histamine H4 receptor ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

29 September 2017

Computer-based de novo design of drug-like molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

29 September 2017

Multiple signaling states of G-protein-coupled receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

29 September 2017

Structure-activity relationships of inverse agonists for G-protein-coupled receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

29 September 2017

Analysis of the third transmembrane domain of the human type 1 angiotensin II receptor by cysteine scanning mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

29 September 2017

The many roles of computation in drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

29 September 2017

Lessons from constitutively active mutants of G protein-coupled receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

29 September 2017

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

29 September 2017

Linking agonist binding to histamine H1 receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

27 November 2018

Phe(303) in TMVI of the alpha(1B)-adrenergic receptor is a key residue coupling TM helical movements to G-protein activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375280

27 November 2018

The active state of the AT1 angiotensin receptor is generated by angiotensin II induction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22719858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanism underlying inverse agonist of angiotensin II type 1 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22719858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of aromaticity of agonist switches of angiotensin II in the activation of the AT1 receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22719858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inverse agonism and neutral antagonism at alpha(1a)- and alpha(1b)-adrenergic receptor subtypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22719858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0037974

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2012PLoSO...737974M

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