(Q28486133)

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Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interference

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scholarly article

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Screening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interference (English)

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multiple drug resistance

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4

object named as

Stuart H Yuspa

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author name string

Megan R Ansbro

1

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Suneet Shukla

2

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Suresh V Ambudkar

3

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Luowei Li

5

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language of work or name

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publication date

2013

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8

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4

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e60334

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copyright license

Creative Commons CC0 License

10 April 2013

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April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

0 references

Advances in the molecular detection of ABC transporters involved in multidrug resistance in cancer

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19 March 2017

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622673

19 March 2017

Targeting multidrug resistance in cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622673

7 April 2017

Mechanisms of cancer drug resistance

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7 April 2017

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

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Reduced efficacy of the Plk1 inhibitor BI 2536 on the progression of hepatocellular carcinoma due to low intratumoral drug levels

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29 September 2017

Evidence for modulatory sites at the lipid-protein interface of the human multidrug transporter P-glycoprotein

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29 September 2017

Mitochondrial localization of P-glycoprotein in the human breast cancer cell line MCF-7/ADM and its functional characterization

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29 September 2017

The molecular interaction of a copper chelate with human P-glycoprotein

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29 September 2017

Use of baculovirus BacMam vectors for expression of ABC drug transporters in mammalian cells

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29 September 2017

A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY-cholesterol

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29 September 2017

Calcein assay: a high-throughput method to assess P-gp inhibition.

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29 September 2017

Predicting drug-drug interactions involving the inhibition of intestinal CYP3A4 and P-glycoprotein

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29 September 2017

The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature

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29 September 2017

N-desmethyl-loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrier

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622673

29 September 2017

Targeting Polo-like kinase in cancer therapy

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29 September 2017

Multidrug efflux pumps: drug binding--gates or cavity?

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622673

29 September 2017

A comparative analysis of standard microtiter plate reading versus imaging in cellular assays

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29 September 2017

High-throughput flow cytometry to detect selective inhibitors of ABCB1, ABCC1, and ABCG2 transporters

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29 September 2017

New inhibitors of ABCG2 identified by high-throughput screening

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29 September 2017

Compound profiling for ABCC2 (MRP2) using a fluorescent microplate assay system

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622673

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ABC drug transporters as molecular targets for the prevention of multidrug resistance and drug-drug interactions.

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29 September 2017

Drug-drug interactions affected by the transporter protein, P-glycoprotein (ABCB1, MDR1) II. Clinical aspects

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29 September 2017

Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoprotein

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A 96-well efflux assay to identify ABCG2 substrates using a stably transfected MDCK II cell line

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A high-throughput cell-based assay for inhibitors of ABCG2 activity

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29 September 2017

Mitotracker green is a P-glycoprotein substrate

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29 September 2017

Allosteric modulation of human P-glycoprotein. Inhibition of transport by preventing substrate translocation and dissociation

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29 September 2017

Mammalian ABC transporters in health and disease

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29 September 2017

Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622673

29 September 2017

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622673

29 September 2017

Ranking of P-glycoprotein substrates and inhibitors by a calcein-AM fluorometry screening assay

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29 September 2017

A new method for a quantitative assessment of P-glycoprotein-related multidrug resistance in tumour cells

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29 September 2017

Drug-stimulated ATPase activity of the human P-glycoprotein

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29 September 2017

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29 September 2017

Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis

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29 September 2017

Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase

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29 September 2017

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

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2 June 2018

Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3622673

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Reduced cyclosporin accumulation in multidrug-resistant cells.

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2 June 2018

Characterization of multidrug resistance by fluorescent dyes.

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2 June 2018

Azidopine noncompetitively interacts with vinblastine and cyclosporin A binding to P-glycoprotein in multidrug resistant cells

1 reference

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2 June 2018

Compound profiling for P-glycoprotein at the blood-brain barrier using a microplate screening system

1 reference

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Reversal of P-glycoprotein mediated multidrug resistance by novel anthranilamide derivatives

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https://pubmed.ncbi.nlm.nih.gov/23593196

12 December 2020

based on heuristic

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In situ hybridization analysis of acquisition and loss of the human multidrug-resistance gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/23593196

12 December 2020

based on heuristic

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Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/23593196

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Communication between multiple drug binding sites on P-glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/23593196

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0060334

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2013PLoSO...860334A

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PubMed publication ID

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