(Q28546678)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25909780%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

title

A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1 (English)

1 reference

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6 March 2020

1 reference

12

1 reference

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6 March 2020

16

Todd R Golub

1 reference

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6 March 2020

15

Alex B Burgin

1 reference

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6 March 2020

author name string

Matthew C Clifton

1

1 reference

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6 March 2020

David M Dranow

2

1 reference

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6 March 2020

Alison Leed

3

1 reference

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6 March 2020

Ben Fulroth

4

1 reference

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6 March 2020

James W Fairman

5

1 reference

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6 March 2020

Jan Abendroth

6

1 reference

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6 March 2020

Kateri A Atkins

7

1 reference

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6 March 2020

Ellen Wallace

8

1 reference

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6 March 2020

Dazhong Fan

9

1 reference

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6 March 2020

Guoping Xu

10

1 reference

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6 March 2020

Z J Ni

11

1 reference

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6 March 2020

John Van Drie

13

1 reference

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6 March 2020

Guo Wei

14

1 reference

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6 March 2020

Brian K Hubbard

17

1 reference

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6 March 2020

Michael H Serrano-Wu

18

1 reference

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6 March 2020

language of work or name

English

0 references

publication date

24 April 2015

1 reference

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6 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25909780%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

volume

10

1 reference

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6 March 2020

issue

4

1 reference

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6 March 2020

page(s)

e0125010

1 reference

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Creative Commons Attribution 4.0 International

6 March 2020

copyright license

start time

24 April 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

High-quality NMR structure of human anti-apoptotic protein domain Mcl-1(171-327) for cancer drug design

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

Collaboration gets the most out of software

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

Chemical genomics identifies small-molecule MCL1 repressors and BCL-xL as a predictor of MCL1 dependency

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

Hallmarks of Cancer: The Next Generation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

Features and development of Coot

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

PHENIX: a comprehensive Python-based system for macromolecular structure solution

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

Integration, scaling, space-group assignment and post-refinement

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

MolProbity: all-atom structure validation for macromolecular crystallography

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

Solving structures of protein complexes by molecular replacement with Phaser

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

Refinement of macromolecular structures by the maximum-likelihood method

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

The CCP4 suite: programs for protein crystallography

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

The landscape of somatic copy-number alteration across human cancers

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

The BCL-2 protein family: opposing activities that mediate cell death

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

Interplay between partner and ligand facilitates the folding and binding of an intrinsically disordered protein

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

Small molecule Mcl-1 inhibitors for the treatment of cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

Direct activation of full-length proapoptotic BAK

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

Mcl-1 is essential for the survival of plasma cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

Direct and selective small-molecule activation of proapoptotic BAX

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

The essential role of evasion from cell death in cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

A synergistic approach to protein crystallization: combination of a fixed-arm carrier with surface entropy reduction.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

Promoting apoptosis as a strategy for cancer drug discovery

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

Crystal structures of fusion proteins with large-affinity tags

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

Myeloid cell factor-1 is a critical survival factor for multiple myeloma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4409056

10.1371/JOURNAL.PONE.0125010

29 September 2017

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25909780%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

ADS bibcode

2015PLoSO..1025010C

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25909780%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

PubMed publication ID

25909780

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25909780%20AND%20SRC:MED&resulttype=core&format=json