(Q28547113)

English

TGF-β Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling Mechanisms

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TGF-β Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling Mechanisms (English)

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author name string

Wei Bin Fang

1

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Benford Mafuvadze

2

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Min Yao

3

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An Zou

4

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Mike Portsche

5

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Nikki Cheng

6

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language of work or name

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publication date

2015

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10

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8

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e0135063

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copyright license

Creative Commons Attribution 4.0 International

7 August 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

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TGFβ signalling in context

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Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element

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19 March 2017

A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo

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19 March 2017

Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif

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19 March 2017

Cross-talk between the proto-oncogenes Met and Ron

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19 March 2017

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling

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19 March 2017

Human Smad3 and Smad4 are sequence-specific transcription activators

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19 March 2017

TGF beta signals through a heteromeric protein kinase receptor complex

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19 March 2017

Fibroblasts in cancer

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7 April 2017

The widespread impact of mammalian MicroRNAs on mRNA repression and evolution

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7 April 2017

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

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7 April 2017

Elevated CXCL1 expression in breast cancer stroma predicts poor prognosis and is inversely associated with expression of TGF-β signaling proteins

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29 September 2017

Signaling pathway cooperation in TGF-β-induced epithelial-mesenchymal transition

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29 September 2017

TGF-beta in CAF-mediated tumor growth and metastasis

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29 September 2017

Fibroblasts in myocardial infarction: a role in inflammation and repair

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29 September 2017

NF-κB and STAT1 control CXCL1 and CXCL2 gene transcription

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29 September 2017

Chemokine (C-X-C motif) ligand 1 (CXCL1) protein expression is increased in high-grade prostate cancer

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29 September 2017

The roles of TGFβ in the tumour microenvironment

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29 September 2017

Carcinoma-associated fibroblasts: non-neoplastic tumour-promoting mesenchymal cells.

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29 September 2017

Hepatocyte growth factor increases vascular endothelial growth factor-A production in human synovial fibroblasts through c-Met receptor pathway

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29 September 2017

CCL2/CCR2 chemokine signaling coordinates survival and motility of breast cancer cells through Smad3 protein- and p42/44 mitogen-activated protein kinase (MAPK)-dependent mechanisms

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29 September 2017

Fibroblast-secreted hepatocyte growth factor mediates epidermal growth factor receptor tyrosine kinase inhibitor resistance in triple-negative breast cancers through paracrine activation of Met

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29 September 2017

A CXCL1 paracrine network links cancer chemoresistance and metastasis

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29 September 2017

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29 September 2017

cMET and phospho-cMET protein levels in breast cancers and survival outcomes

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529193

29 September 2017

Targeting MET in cancer: rationale and progress

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529193

29 September 2017

Transforming Growth Factor-β and Endoglin Signaling Orchestrate Wound Healing

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29 September 2017

Mammary transplantation of stromal cells and carcinoma cells in C57BL/6J mice

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29 September 2017

Transforming growth factor-β signaling in tumor initiation, progression and therapy in breast cancer: an update

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529193

29 September 2017

Role of Smads in TGFβ signaling

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529193

29 September 2017

Loss of one Tgfbr2 allele in fibroblasts promotes metastasis in MMTV: polyoma middle T transgenic and transplant mouse models of mammary tumor progression

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529193

29 September 2017

HGF-promoted motility in primary human melanocytes depends on CD44v6 regulated via NF-kappa B, Egr-1, and C/EBP-beta

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29 September 2017

Transcription factor Smad3 is required for the inhibition of adipogenesis by retinoic acid

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29 September 2017

HGF upregulates CXCR4 expression in gliomas via NF-kappaB: implications for glioma cell migration

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29 September 2017

Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model

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29 September 2017

Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situ

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529193

29 September 2017

Identification of GRO1 as a critical determinant for mutant p53 gain of function

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29 September 2017

Transforming growth factor-beta signaling-deficient fibroblasts enhance hepatocyte growth factor signaling in mammary carcinoma cells to promote scattering and invasion

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529193

29 September 2017

CXC chemokines and their receptors: a case for a significant biological role in cutaneous wound healing

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29 September 2017

Secreted CXCL1 is a potential mediator and marker of the tumor invasion of bladder cancer.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529193

29 September 2017

Stromal gene expression predicts clinical outcome in breast cancer

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

Human breast fibroblasts inhibit growth of the MCF10AT xenograft model of proliferative breast disease

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29 September 2017

Differential regulation of CXC ligand 1 transcription in melanoma cell lines by poly(ADP-ribose) polymerase-1.

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29 September 2017

Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks

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29 September 2017

Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile.

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29 September 2017

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29 September 2017

Molecular characterization of the tumor microenvironment in breast cancer

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function

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29 September 2017

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29 September 2017

Role of CXCL1 in tumorigenesis of melanoma.

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29 September 2017

Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3.

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29 September 2017

Expression of the c-Met/HGF receptor in human breast carcinoma: correlation with tumor progression

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29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529193

3 June 2018

Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529193

3 June 2018

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21 January 2018

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1 reference

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https://pubmed.ncbi.nlm.nih.gov/26252654

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https://pubmed.ncbi.nlm.nih.gov/26252654

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https://pubmed.ncbi.nlm.nih.gov/26252654

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[Downregulation of Duffy antigen receptor for chemokine (DARC) is associated with lymph node metastasis in human breast cancer]

1 reference

https://pubmed.ncbi.nlm.nih.gov/26252654

12 December 2020

based on heuristic

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https://pubmed.ncbi.nlm.nih.gov/26252654

12 December 2020

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12 December 2020

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1 reference

https://pubmed.ncbi.nlm.nih.gov/26252654

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1 reference

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Identifiers

10.1371/JOURNAL.PONE.0135063

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2015PLoSO..1035063F

0 references

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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