(Q28568790)

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662332%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

title

Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease (English)

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662332%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

0 references

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662332%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Hikaru Ito

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662332%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Erich Wanker

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662332%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

9

Nobutaka Arai

2 references

31 January 2017

11 January 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662332%20AND%20SRC:MED&resulttype=core&format=json

Reina Inagaki

1

object named as

Reina Inagaki

2 references

31 January 2017

11 January 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662332%20AND%20SRC:MED&resulttype=core&format=json

Kazuhiko Tagawa

2

object named as

Kazuhiko Tagawa

2 references

31 January 2017

11 January 2020

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662332%20AND%20SRC:MED&resulttype=core&format=json

author name string

Mei-Ling Qi

3

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662332%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Takuya Tamura

6

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662332%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Shigeomi Shimizu

7

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662332%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Kityomitsu Oyanagi

8

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662332%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Ichiro Kanazawa

10

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662332%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

Hitoshi Okazawa

12

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662332%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

language of work or name

English

0 references

publication date

1 July 2008

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662332%20AND%20SRC:MED&resulttype=core&format=json

European Journal of Neuroscience

11 January 2020

published in

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662332%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

volume

28

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662332%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

issue

1

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662332%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

page(s)

30-40

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662332%20AND%20SRC:MED&resulttype=core&format=json

Multicopy suppressors of prc mutant Escherichia coli include two HtrA (DegP) protease homologs (HhoAB), DksA, and a truncated R1pA.

11 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

The HtrA Family of Proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

Akt is altered in an animal model of Huntington's disease and in patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

General transcriptional repression by polyglutamine disease proteins is not directly linked to the presence of inclusion bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

mnd2: a new mouse model of inherited motor neuron disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

Interaction between mutant ataxin-1 and PQBP-1 affects transcription and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

PQBP-1 is expressed predominantly in the central nervous system during development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

Progressive loss of striatal neurons causes motor dysfunction in MND2 mutant mice and is not prevented by Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

Distinct aggregation and cell death patterns among different types of primary neurons induced by mutant huntingtin protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1460-9568.2008.06323.X

10.1111/J.1460-9568.2008.06323.X

21 January 2018

Identifiers

DOI

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18662332%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

2 references

31 January 2017