(Q47613425)

4 February 2018

title

Distinct aggregation and cell death patterns among different types of primary neurons induced by mutant huntingtin protein (English)

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4 February 2018

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9

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4 February 2018

Sabine Engemann

6

object named as

Sabine Engemann

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4 February 2018

Masataka Hoshino

2

object named as

Masataka Hoshino

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4 February 2018

Kazuhiko Tagawa

1

object named as

Kazuhiko Tagawa

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4 February 2018

author name string

Tomohiro Okuda

3

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4 February 2018

Hiroko Ueda

4

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4 February 2018

Hiroshi Hayashi

5

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4 February 2018

Haruo Okado

7

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4 February 2018

Masumi Ichikawa

8

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4 February 2018

Hitoshi Okazawa

10

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4 February 2018

language of work or name

English

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publication date

1 May 2004

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4 February 2018

Journal of Neurochemistry

published in

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4 February 2018

volume

89

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4 February 2018

issue

4

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4 February 2018

page(s)

974-987

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4 February 2018

Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Fourteen and counting: unraveling trinucleotide repeat diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Regulation of expanded polyglutamine protein aggregation and nuclear localization by the glucocorticoid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Nuclear inclusions in spinocerebellar ataxia type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Mutant protein in Huntington disease is resistant to proteolysis in affected brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Histone deacetylase activity is retained in primary neurons expressing mutant huntingtin protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

The linkage of Kennedy's neuron disease to ARA24, the first identified androgen receptor polyglutamine region-associated coactivator

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Inhibition of p160-mediated coactivation with increasing androgen receptor polyglutamine length

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Genetic suppression of polyglutamine toxicity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Disruption of CREB function in brain leads to neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Nuclear localization of N-terminal mutant huntingtin is cell cycle dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Histone deacetylase inhibitors reduce polyglutamine toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

CREB-binding protein sequestration by expanded polyglutamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Interaction between mutant ataxin-1 and PQBP-1 affects transcription and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Disassembly of nuclear inclusions in the dividing cell--a novel insight into neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Motoneuronal cell death is not correlated with aggregate formation of androgen receptors containing an elongated polyglutamine tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Intranuclear ataxin1 inclusions contain both fast- and slow-exchanging components

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

SCA7 mouse models show selective stabilization of mutant ataxin-7 and similar cellular responses in different neuronal cell types

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2004.02372.X

10.1111/J.1471-4159.2004.02372.X

21 January 2018

Identifiers

DOI

1 reference

4 February 2018

1 reference

4 February 2018