(Q28570722)

31 January 2017

title

p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis (English)

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31 January 2017

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3

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31 January 2017

8

Sally A. Frautschy

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31 January 2017

Qiu-Lan Ma

1

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31 January 2017

Fusheng Yang

2

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31 January 2017

Oliver J. Ubeda

4

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31 January 2017

James E. Hansen

5

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31 January 2017

Richard H. Weisbart

6

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31 January 2017

Walter Beech

7

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31 January 2017

Greg M. Cole

9

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31 January 2017

language of work or name

English

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publication date

16 May 2008

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Journal of Biological Chemistry

31 January 2017

published in

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31 January 2017

volume

283

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31 January 2017

issue

20

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31 January 2017

page(s)

14132–14143

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Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice

31 January 2017

cites work

1 reference

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A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

19 March 2017

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Regulation of NMDA receptor trafficking by amyloid-beta

19 March 2017

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The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines

19 March 2017

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The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus

19 March 2017

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Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin

19 March 2017

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Pak1 is involved in dendrite initiation as a downstream effector of Rac1 in cortical neurons

19 March 2017

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Rho proteins, mental retardation and the cellular basis of cognition

19 March 2017

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

19 March 2017

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alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A beta-amyloid-induced neurotoxicity

19 March 2017

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Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

19 March 2017

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Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

19 March 2017

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A specific amyloid-beta protein assembly in the brain impairs memory

19 March 2017

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

19 March 2017

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

7 April 2017

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APP processing and synaptic function

7 April 2017

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Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo

7 April 2017

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Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

7 April 2017

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Signal transduction in Alzheimer disease: p21-activated kinase signaling requires C-terminal cleavage of APP at Asp664.

7 April 2017

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Integrins mediate beta-amyloid-induced cell-cycle activation and neuronal death.

29 September 2017

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Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

29 September 2017

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Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro.

29 September 2017

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Rho GTPases, dendritic structure, and mental retardation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376243

Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376243

Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

29 September 2017

1 reference

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Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376243

Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376243

Microanatomy of dendritic spines: emerging principles of synaptic pathology in psychiatric and neurological disease

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376243

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376243

Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376243

Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila

29 September 2017

1 reference

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Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy

29 September 2017

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Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice

3 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376243

Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons.

3 June 2018

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Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease

3 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376243

Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376243

The neuronal architecture of Xenopus retinal ganglion cells is sculpted by rho-family GTPases in vivo

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376243

Regulation of dendritic growth and remodeling by Rho, Rac, and Cdc42.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376243

Dendritic Spine "Dysgenesis" and Mental Retardation

3 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708034200

Dendrite and dendritic spine alterations in Alzheimer models

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708034200

Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708034200

Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708034200

Regulation of postsynaptic structure and protein localization by the Rho-type guanine nucleotide exchange factor dPix

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708034200

Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708034200

Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708034200

Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708034200

Self-assembly of Abeta(1-42) into globular neurotoxins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708034200

Abeta1-42 stimulates actin polymerization in hippocampal neurons through Rac1 and Cdc42 Rho GTPases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708034200

Phosphorylation of actin-depolymerizing factor/cofilin by LIM-kinase mediates amyloid beta-induced degeneration: a potential mechanism of neuronal dystrophy in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708034200

Signaling from integrins to Fyn to Rho family GTPases regulates morphologic differentiation of oligodendrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708034200

Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2376243

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

27 November 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708034200

Rho GTPases regulate distinct aspects of dendritic arbor growth in Xenopus central neurons in vivo

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/18347024