(Q28571192)

31 January 2017

title

Cyclin-dependent kinase 5 phosphorylates serine 31 of tyrosine hydroxylase and regulates its stability (English)

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31 January 2017

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2

Li-Huei Tsai

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31 January 2017

Lily Y. Moy

1

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31 January 2017

language of work or name

English

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publication date

24 December 2004

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Journal of Biological Chemistry

31 January 2017

published in

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volume

279

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issue

52

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31 January 2017

page(s)

54487–54493

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Targeted Disruption of the Tyrosine Hydroxylase Locus Results in Severe Catecholamine Depletion and Perinatal Lethality in Mice

31 January 2017

cites work

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Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development

21 January 2018

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Tetrahydropterin-dependent amino acid hydroxylases

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Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

21 January 2018

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A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1.

21 January 2018

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p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway

21 January 2018

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ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1.

21 January 2018

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ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ

21 January 2018

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

21 January 2018

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Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

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Enhancement of tyrosine hydroxylase phosphorylation and activity by glial cell line-derived neurotrophic factor

21 January 2018

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Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

21 January 2018

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Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2

21 January 2018

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Recessively inherited L-DOPA-responsive parkinsonism in infancy caused by a point mutation (L205P) in the tyrosine hydroxylase gene

21 January 2018

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Cytotoxic and genotoxic potential of dopamine

21 January 2018

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Etiology and pathogenesis of Parkinson's disease

21 January 2018

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p35 nck5a and cyclin-dependent kinase 5 colocalize in Lewy bodies of brains with Parkinson's disease

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M406636200

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31 January 2017

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