(Q28574836)

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The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis

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scholarly article

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18411275%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis (English)

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18411275%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

Alzheimer's disease

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Sergio B. Kaufman

5

1 reference

Europe PubMed Central

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5 January 2020

author name string

Matías de Tullio

2

2 references

31 January 2017

Europe PubMed Central

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5 January 2020

Gonzalo de Prat Gay

7

2 references

31 January 2017

Europe PubMed Central

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5 January 2020

Laura Morelli

8

2 references

31 January 2017

Europe PubMed Central

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5 January 2020

Ramiro E Llovera

1

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5 January 2020

Leonardo G Alonso

3

1 reference

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5 January 2020

Malcolm A Leissring

4

1 reference

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5 January 2020

Alex E Roher

6

1 reference

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5 January 2020

Eduardo M Castaño

9

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5 January 2020

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14 April 2008

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5 January 2020

Journal of Biological Chemistry

2 references

31 January 2017

Europe PubMed Central

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5 January 2020

283

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31 January 2017

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5 January 2020

25

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31 January 2017

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5 January 2020

17039-17048

1 reference

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5 January 2020

The degradation of amyloid beta as a therapeutic strategy in Alzheimer's disease and cerebrovascular amyloidoses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Metabolic regulation of brain Abeta by neprilysin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Differential effects of proteases involved in intracellular degradation of amyloid beta-protein between detergent-soluble and -insoluble pools in CHO-695 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Insulin-degrading enzyme: embarking on amyloid destruction.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Differential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Insulin-degrading enzyme degrades amyloid peptides associated with British and Danish familial dementia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Hyperinsulinemia and risk of Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Susceptibility of amyloid beta peptide degrading enzymes to oxidative damage: a potential Alzheimer's disease spiral

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

The length of amyloid-beta in hereditary cerebral hemorrhage with amyloidosis, Dutch type. Implications for the role of amyloid-beta 1-42 in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Physical, morphological and functional differences between ph 5.8 and 7.4 aggregates of the Alzheimer's amyloid peptide Abeta

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Comparison of four staining methods on the detection of neuritic plaques

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Modified amyloid beta protein ending at 42 or 40 with different solubility accumulates in the brain of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Insulin-degrading enzyme in the Alzheimer's disease brain: prominent localization in neurons and senile plaques.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Identification of gamma-endorphin-generating enzyme as insulin-degrading enzyme

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

SDS-stable complex formation between native apolipoprotein E3 and beta-amyloid peptides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Alpha2-macroglobulin associates with beta-amyloid peptide and prevents fibril formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Transthyretin sequesters amyloid beta protein and prevents amyloid formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Binding of gelsolin, a secretory protein, to amyloid beta-protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Beta-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

The Alzheimer's peptide a beta adopts a collapsed coil structure in water

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

3D structure of Alzheimer's amyloid-beta(1-42) fibrils

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Seeding specificity in amyloid growth induced by heterologous fibrils

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Thermodynamics of A beta(1-40) amyloid fibril elongation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Distinct early folding and aggregation properties of Alzheimer amyloid-beta peptides Abeta40 and Abeta42: stable trimer or tetramer formation by Abeta42.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Cleavage of amyloid beta peptide during constitutive processing of its precursor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706316200

21 January 2018

Identifiers

10.1074/JBC.M706316200

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18411275%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

2 references

31 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18411275%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

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