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Varenicline is a potent partial agonist at α6β2* nicotinic acetylcholine receptors in rat and monkey striatum
scientific journal article
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scholarly article
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PubMed
PubMed ID
22550286
retrieved
31 January 2017
title
Varenicline is a potent partial agonist at α6β2* nicotinic acetylcholine receptors in rat and monkey striatum
(English)
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PubMed
PubMed ID
22550286
retrieved
31 January 2017
main subject
acetylcholine
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based on heuristic
inferred from title
striatum
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inferred from title
varenicline
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author name string
Tanuja Bordia
series ordinal
1
1 reference
stated in
PubMed
PubMed ID
22550286
retrieved
31 January 2017
Maya Hrachova
series ordinal
2
1 reference
stated in
PubMed
PubMed ID
22550286
retrieved
31 January 2017
Matthew Chin
series ordinal
3
1 reference
stated in
PubMed
PubMed ID
22550286
retrieved
31 January 2017
J. Michael McIntosh
series ordinal
4
1 reference
stated in
PubMed
PubMed ID
22550286
retrieved
31 January 2017
Maryka Quik
series ordinal
5
1 reference
stated in
PubMed
PubMed ID
22550286
retrieved
31 January 2017
language of work or name
English
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publication date
1 August 2012
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PubMed
PubMed ID
22550286
retrieved
31 January 2017
published in
Journal of Pharmacology and Experimental Therapeutics
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stated in
PubMed
PubMed ID
22550286
retrieved
31 January 2017
volume
342
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stated in
PubMed
PubMed ID
22550286
retrieved
31 January 2017
issue
2
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PubMed
PubMed ID
22550286
retrieved
31 January 2017
page(s)
327–334
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stated in
PubMed
PubMed ID
22550286
retrieved
31 January 2017
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ImageQuant
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Europe PubMed Central
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11 June 2022
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3400806/fullTextXML
based on heuristic
inferred from PubMed Central ID database lookup
cites work
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PubMed Central
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17 March 2017
Desensitization of nicotinic acetylcholine receptors as a strategy for drug development
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PubMed Central
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17 March 2017
Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration
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17 March 2017
The neuronal nicotinic acetylcholine receptors alpha 4* and alpha 6* differentially modulate dopamine release in mouse striatal slices
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17 March 2017
Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors
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PubMed Central
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17 March 2017
Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation
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Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine
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A single administration of low-dose varenicline saturates α4β2* nicotinic acetylcholine receptors in the human brain.
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PubMed Central
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29 September 2017
Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo
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PubMed Central
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29 September 2017
Low concentrations of nicotine differentially desensitize nicotinic acetylcholine receptors that include α5 or α6 subunits and that mediate synaptosomal neurotransmitter release
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29 September 2017
Adjunctive varenicline treatment with antipsychotic medications for cognitive impairments in people with schizophrenia: a randomized double-blind placebo-controlled trial
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29 September 2017
Varenicline is a potent agonist of the human 5-hydroxytryptamine3 receptor.
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29 September 2017
Varenicline as a smoking cessation aid in schizophrenia: effects on smoking behavior and reward sensitivity
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29 September 2017
Nicotine reduces L-DOPA-induced dyskinesias by acting at beta2* nicotinic receptors
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PubMed Central
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29 September 2017
Varenicline for tobacco dependence: panacea or plight?
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PubMed Central
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29 September 2017
Varenicline effects on craving, cue reactivity, and smoking reward
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29 September 2017
Pharmacotherapy for smoking cessation: current advances and research topics
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29 September 2017
Reward, addiction, withdrawal to nicotine
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29 September 2017
Selective α4β2 nicotinic acetylcholine receptor agonists target epigenetic mechanisms in cortical GABAergic neurons
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PubMed Central
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29 September 2017
bPiDI: a novel selective α6β2* nicotinic receptor antagonist and preclinical candidate treatment for nicotine abuse
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PubMed Central
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29 September 2017
Partial agonists of the α3β4* neuronal nicotinic acetylcholine receptor reduce ethanol consumption and seeking in rats
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29 September 2017
Varenicline blocks nicotine intake in rats with extended access to nicotine self-administration
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PubMed Central
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29 September 2017
Expression of functional human α6β2β3* acetylcholine receptors in Xenopus laevis oocytes achieved through subunit chimeras and concatamers
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29 September 2017
Smoking cessation-recent advances
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29 September 2017
Alpha3* and alpha 7 nAChR-mediated Ca2+ transient generation in IMR-32 neuroblastoma cells
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Nicotine addiction and nicotinic receptors: lessons from genetically modified mice
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29 September 2017
Nicotinic receptor-mediated reduction in L-DOPA-induced dyskinesias may occur via desensitization
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29 September 2017
Structural differences determine the relative selectivity of nicotinic compounds for native alpha 4 beta 2*-, alpha 6 beta 2*-, alpha 3 beta 4*- and alpha 7-nicotine acetylcholine receptors
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29 September 2017
Alpha-conotoxin MII-sensitive nicotinic acetylcholine receptors in the nucleus accumbens shell regulate progressive ratio responding maintained by nicotine
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PubMed Central
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29 September 2017
Roles for nigrostriatal--not just mesocorticolimbic--dopamine in reward and addiction
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29 September 2017
Nicotine and behavioral sensitization
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PubMed Central
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29 September 2017
The role of alpha6-containing nicotinic acetylcholine receptors in nicotine reward and withdrawal
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PubMed Central
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29 September 2017
Stimulation of dopamine release by nicotinic acetylcholine receptor ligands in rat brain slices correlates with the profile of high, but not low, sensitivity alpha4beta2 subunit combination
1 reference
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PubMed Central
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29 September 2017
Molecular and cellular mechanisms of action of nicotine in the CNS.
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PubMed Central
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29 September 2017
Targeting nicotinic receptor antagonists as novel pharmacotherapies for tobacco dependence and relapse
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PubMed Central
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29 September 2017
Brain nicotinic acetylcholine receptor occupancy: effect of smoking a denicotinized cigarette
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PubMed Central
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29 September 2017
Long-term nicotine treatment differentially regulates striatal alpha6alpha4beta2* and alpha6(nonalpha4)beta2* nAChR expression and function
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PubMed Central
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29 September 2017
Tobacco addiction
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PubMed Central
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29 September 2017
It is not "either/or": activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood
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PubMed Central
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29 September 2017
Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens.
1 reference
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PubMed Central
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29 September 2017
Rationale, pharmacology and clinical efficacy of partial agonists of alpha4beta2 nACh receptors for smoking cessation
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PubMed Central
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29 September 2017
Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400806
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29 September 2017
Efficacy of varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation: a randomized controlled trial
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400806
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29 September 2017
Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, vs sustained-release bupropion and placebo for smoking cessation: a randomized controlled trial.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400806
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29 September 2017
The use of 3H standards in 125I autoradiography
1 reference
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PubMed Central
reference URL
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29 September 2017
Compensation in pre-synaptic dopaminergic function following nigrostriatal damage in primates
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400806
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3 June 2018
Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors.
1 reference
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PubMed Central
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3 June 2018
Vulnerability of 125I-alpha-conotoxin MII binding sites to nigrostriatal damage in monkey.
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PubMed Central
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3 June 2018
The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400806
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3 June 2018
Nicotinic acetylcholine receptors in the mesolimbic pathway: primary role of ventral tegmental area alpha6beta2* receptors in mediating systemic nicotine effects on dopamine release, locomotion, and reinforcement.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400806
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27 November 2018
Effects of varenicline and mecamylamine on the acquisition, expression, and reinstatement of nicotine-conditioned place preference by drug priming in rats
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400806
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27 November 2018
The alpha4beta2 nicotinic acetylcholine-receptor partial agonist varenicline inhibits both nicotine self-administration following repeated dosing and reinstatement of nicotine seeking in rats
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400806
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27 November 2018
Effect of the alpha4beta2* nicotinic acetylcholine receptor partial agonist varenicline on dopamine release in beta2 knock-out mice with selective re-expression of the beta2 subunit in the ventral tegmental area
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PubMed Central
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27 November 2018
Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400806
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27 November 2018
Decrease in alpha3*/alpha6* nicotinic receptors but not nicotine-evoked dopamine release in monkey brain after nigrostriatal damage
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400806
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27 November 2018
Differential declines in striatal nicotinic receptor subtype function after nigrostriatal damage in mice
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400806
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27 November 2018
Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400806
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27 November 2018
Identifiers
DOI
10.1124/JPET.112.194852
1 reference
stated in
PubMed
PubMed ID
22550286
retrieved
31 January 2017
PMCID
3400806
0 references
PubMed ID
22550286
1 reference
stated in
PubMed
PubMed ID
22550286
retrieved
31 January 2017
ResearchGate publication ID
224879450
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