(Q28586625)

31 January 2017

title

PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling (English)

1 reference

Proprotein convertase subtilisin/kexin type 9

31 January 2017

0 references

1 reference

GOA release 2020-03-11

Kai Kysenius

1

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Urmas Arumäe

object named as

Urmas Arumäe

4

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Henri J. Huttunen

object named as

Henri J. Huttunen

5

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author name string

Pranuthi Muggalla

2

1 reference

31 January 2017

Kert Mätlik

3

1 reference

31 January 2017

publication date

1 June 2012

1 reference

Cellular and Molecular Life Sciences

31 January 2017

published in

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31 January 2017

volume

69

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31 January 2017

issue

11

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31 January 2017

page(s)

1903–1916

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Apoptosis in the nervous system

31 January 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

21 January 2018

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Proapoptotic effects of NARC 1 (= PCSK9), the gene encoding a novel serine proteinase

21 January 2018

1 reference

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PCSK9 binds to multiple receptors and can be functionally inhibited by an EGF-A peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

A two-step binding model of PCSK9 interaction with the low density lipoprotein receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke

21 January 2018

1 reference

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21 January 2018

1 reference

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Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2

21 January 2018

1 reference

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The Reelin receptors Apoer2 and Vldlr coordinate the patterning of Purkinje cell topography in the developing mouse cerebellum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

ApoE receptor 2 controls neuronal survival in the adult brain

21 January 2018

1 reference

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Differential binding of ligands to the apolipoprotein E receptor 2.

21 January 2018

1 reference

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Reelin, very-low-density lipoprotein receptor, and apolipoprotein E receptor 2 control somatic NMDA receptor composition during hippocampal maturation in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system

21 January 2018

1 reference

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Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9

21 January 2018

1 reference

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Inhibition of PCSK9 as a novel strategy for the treatment of hypercholesterolemia

21 January 2018

1 reference

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Cerebellar granule cells as a model to study mechanisms of neuronal apoptosis or survival in vivo and in vitro

21 January 2018

1 reference

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Cell culture of primary cerebellar granule cells

21 January 2018

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Caspase activation pathways induced by staurosporine and low potassium: role of caspase-2.

21 January 2018

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Concomitant induction of apoptosis and necrosis in cerebellar granule cells following serum and potassium withdrawal.

21 January 2018

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Multiple pathways of apolipoprotein E signaling in primary neurons

21 January 2018

1 reference

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Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

Reelin signaling antagonizes beta-amyloid at the synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

Coupling of the NMDA receptor to neuroprotective and neurodestructive events

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

N-methyl-D-aspartate blocks activation of JNK and mitochondrial apoptotic pathway induced by potassium deprivation in cerebellar granule cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

Reelin modulates NMDA receptor activity in cortical neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

ERK1/2 are involved in low potassium-induced apoptotic signaling downstream of ASK1-p38 MAPK pathway in cultured cerebellar granule neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

Neuroprotection by c-Jun NH2-terminal kinase inhibitor SP600125 against potassium deprivation-induced apoptosis involves the Akt pathway and inhibition of cell cycle reentry

21 January 2018

1 reference

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Study of the pathways involved in apoptosis induced by PI3K inhibition in cerebellar granule neurons.

21 January 2018

1 reference

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Mechanism of NF-kappaB inactivation induced by survival signal withdrawal in cerebellar granule neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

Role of oxidative stress and JNK pathway in apoptotic death induced by potassium deprivation and staurosporine in cerebellar granule neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

Direct inhibition of c-Jun N-terminal kinase in sympathetic neurones prevents c-jun promoter activation and NGF withdrawal-induced death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

PACAP up-regulates the expression of apolipoprotein D in 3T3-L1 adipocytes. DRG/3T3-L1 co-cultures study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

An orchestrated gene expression component of neuronal programmed cell death revealed by cDNA array analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

Reelin, lipoprotein receptors and synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

The activation and physiological functions of the proprotein convertases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

Genome-wide expression analysis of cells expressing gain of function mutant D374Y-PCSK9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

NMDA receptor-dependent CREB activation in survival of cerebellar granule cells during in vivo and in vitro development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

The role of apolipoprotein E in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

No genetic association between PCSK9 polymorphisms and Alzheimer's disease and plasma cholesterol level in Japanese patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-0977-6

c-Jun N-terminal protein kinase (JNK) 2/3 is specifically activated by stress, mediating c-Jun activation, in the presence of constitutive JNK1 activity in cerebellar neurons.

21 January 2018

1 reference

12 December 2020

PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway

1 reference

12 December 2020

Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons

1 reference

12 December 2020

Constitutive nuclear factor-kappa B activity is required for central neuron survival.

1 reference

12 December 2020

Inhibition of JNK by overexpression of the JNL binding domain of JIP-1 prevents apoptosis in sympathetic neurons

1 reference

12 December 2020

Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity

1 reference

12 December 2020

ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

1 reference

12 December 2020

Metabolic and genetic analyses of apoptosis in potassium/serum-deprived rat cerebellar granule cells

1 reference

12 December 2020