(Q28588141)

31 January 2017

title

Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer (English)

1 reference

MER proto-oncogene tyrosine kinase

31 January 2017

main subject

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AXL receptor tyrosine kinase

GOA release 2020-03-11

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GOA release 2020-03-11

1 reference

Carla V. Rothlin

9

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author name string

Lidia Bosurgi

1

1 reference

31 January 2017

Jochem H. Bernink

2

1 reference

31 January 2017

Victor Delgado Cuevas

3

1 reference

31 January 2017

Nicola Gagliani

4

1 reference

31 January 2017

Leonel Joannas

5

1 reference

31 January 2017

Edward T. Schmid

6

1 reference

31 January 2017

Carmen J. Booth

7

1 reference

31 January 2017

Sourav Ghosh

8

1 reference

31 January 2017

language of work or name

English

0 references

publication date

6 August 2013

1 reference

Proceedings of the National Academy of Sciences of the United States of America

31 January 2017

published in

1 reference

31 January 2017

volume

110

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31 January 2017

issue

32

1 reference

31 January 2017

page(s)

13091–13096

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Hallmarks of Cancer: The Next Generation

31 January 2017

cites work

1 reference

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TAM receptors are pleiotropic inhibitors of the innate immune response

17 March 2017

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Twist mediates suppression of inflammation by type I IFNs and Axl

17 March 2017

1 reference

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Tyro-3 family receptors are essential regulators of mammalian spermatogenesis

17 March 2017

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Cloning and mRNA expression analysis of a novel human protooncogene, c-mer

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Fate mapping analysis reveals that adult microglia derive from primitive macrophages

17 March 2017

1 reference

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IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

7 April 2017

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Alternative activation of macrophages: an immunologic functional perspective

7 April 2017

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Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

7 April 2017

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A lineage of myeloid cells independent of Myb and hematopoietic stem cells

7 April 2017

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T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response

7 April 2017

1 reference

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Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes

29 September 2017

1 reference

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MERTK receptor tyrosine kinase is a therapeutic target in melanoma.

29 September 2017

1 reference

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Clearing the dead: apoptotic cell sensing, recognition, engulfment, and digestion

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Differential expression of Axl and correlation with invasion and multidrug resistance in cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Regulation of NF-κB by deubiquitinases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

The receptor tyrosine kinase Axl is an essential regulator of prostate cancer proliferation and tumor growth and represents a new therapeutic target.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Design, Synthesis and Biological Evaluation of a Series of Novel Axl Kinase Inhibitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Targeting Axl and Mer kinases in cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

AXL regulates mesothelioma proliferation and invasiveness

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

TAM receptor signaling and autoimmune disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Overexpression of receptor tyrosine kinase Axl promotes tumor cell invasion and survival in pancreatic ductal adenocarcinoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Inflammation and colon cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Inflammation and oncogenesis: a vicious connection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Organ- and cell-type specific delivery of kinase inhibitors: a novel approach in the development of targeted drugs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

A protective function for interleukin 17A in T cell-mediated intestinal inflammation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Decreasing time-trends of colorectal cancer in a large cohort of patients with inflammatory bowel disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Immunobiology of the TAM receptors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Ulcerative colitis and colorectal cancer. A population-based study

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-kappaB transcriptional activat

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Chemically induced mouse models of intestinal inflammation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

Axl and growth arrest-specific gene 6 are frequently overexpressed in human gliomas and predict poor prognosis in patients with glioblastoma multiforme

3 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1302507110

R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1302507110

Axl, a novel receptor tyrosine kinase isolated from chronic myelogenous leukemia.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3740859

27 November 2018

Identifiers

DOI

10.1073/PNAS.1302507110

1 reference

ADS bibcode

2013PNAS..11013091B

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1 reference

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