(Q28606437)

7

0 references

Gad Getz

8

0 references

Ignaty Leshchiner

object named as

Ignaty Leshchiner

4

0 references

Todd Golub

6

object named as

Todd R Golub

0 references

author name string

Atanas Kamburov

1

0 references

Michael S Lawrence

2

0 references

Paz Polak

3

0 references

Kasper Lage

Proceedings of the National Academy of Sciences of the United States of America

5

0 references

language of work or name

English

0 references

publication date

6 October 2015

0 references

published in

0 references

volume

112

0 references

page(s)

E5486-95

0 references

issue

40

0 references

cites work

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Three-dimensional reconstruction of protein networks provides insight into human genetic disease

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Crystal structure of human Mre11: understanding tumorigenic mutations

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Asyn-anticonformational difference allows SRSF2 to recognize guanines and cytosines equally well

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Initial genome sequencing and analysis of multiple myeloma

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Hallmarks of Cancer: The Next Generation

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O-GlcNAc transferase catalyzes site-specific proteolysis of HCF-1

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The Ndc80 kinetochore complex forms oligomeric arrays along microtubules

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Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

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Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1

17 March 2017

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The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A

17 March 2017

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The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

17 March 2017

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Homodimeric structure and double-stranded RNA cleavage activity of the C-terminal RNase III domain of human dicer

17 March 2017

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The tumor suppressor PP2A Abeta regulates the RalA GTPase

17 March 2017

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Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases

17 March 2017

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Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage

17 March 2017

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Epidermal growth factor receptor dimerization and activation require ligand-induced conformational changes in the dimer interface

17 March 2017

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

17 March 2017

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A census of human cancer genes

17 March 2017

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X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors

17 March 2017

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Ribonuclease activity and RNA binding of recombinant human Dicer

17 March 2017

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

17 March 2017

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Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

17 March 2017

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Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

17 March 2017

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Protein domain-level landscape of cancer-type-specific somatic mutations

17 March 2017

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Oncotator: cancer variant annotation tool

29 September 2017

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siRNA-mediated knockdown against NUF2 suppresses pancreatic cancer proliferation in vitro and in vivo

29 September 2017

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Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer

29 September 2017

1 reference

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Somatic ERCC2 mutations correlate with cisplatin sensitivity in muscle-invasive urothelial carcinoma

29 September 2017

1 reference

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A spatial simulation approach to account for protein structure when identifying non-random somatic mutations

29 September 2017

1 reference

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Elucidating common structural features of human pathogenic variations using large-scale atomic-resolution protein networks

29 September 2017

1 reference

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Cell division cycle-associated protein 1 overexpression is essential for the malignant potential of colorectal cancers

29 September 2017

1 reference

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High-resolution network biology: connecting sequence with function

29 September 2017

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Pan-cancer patterns of somatic copy number alteration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

OncodriveCLUST: exploiting the positional clustering of somatic mutations to identify cancer genes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

Dissecting disease inheritance modes in a three-dimensional protein network challenges the "guilt-by-association" principle

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

NK cell-based immunotherapy for malignant diseases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

CAND1 promotes PLK4-mediated centriole overduplication and is frequently disrupted in prostate cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

DNA demethylation by TDG.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

A comprehensive survey of Ras mutations in cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

VHL gene mutations and their effects on hypoxia inducible factor HIFα: identification of potential driver and passenger mutations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

The structural impact of cancer-associated missense mutations in oncogenes and tumor suppressors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

Frequent truncating mutation of TFAM induces mitochondrial DNA depletion and apoptotic resistance in microsatellite-unstable colorectal cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

A MicroRNA targeting dicer for metastasis control

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

siRNA-mediated knockdown against CDCA1 and KNTC2, both frequently overexpressed in colorectal and gastric cancers, suppresses cell proliferation and induces apoptosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

Integrating diverse data for structure determination of macromolecular assemblies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

mTORC1 signaling requires proteasomal function and the involvement of CUL4-DDB1 ubiquitin E3 ligase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

Activation of CDCA1-KNTC2, members of centromere protein complex, involved in pulmonary carcinogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

The kinetochore and cancer: what's the connection?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

Silencing of NUF2 inhibits tumor growth and induces apoptosis in human hepatocellular carcinomas

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

e-Driver: a novel method to identify protein regions driving cancer

3 June 2018

1 reference

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Edgetic perturbation models of human inherited disorders

3 June 2018

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p53 mutation in hepatocellular carcinoma after aflatoxin exposure

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4603469

dSysMap: exploring the edgetic role of disease mutations.

3 June 2018

1 reference

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FBXW7/hCDC4 is a general tumor suppressor in human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1516373112

Altered pattern of Cul-1 protein expression and neddylation in human lung tumours: relationships with CAND1 and cyclin E protein levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1516373112

MAX Mutations Cause Hereditary and Sporadic Pheochromocytoma and Paraganglioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1516373112

21 January 2018

Identifiers

DOI

10.1073/PNAS.1516373112

1 reference

1340862

ADS bibcode

2015PNAS..112E5486K

0 references

1340862

1 reference

1 reference

1 reference