(Q28677042)

English

Integrated enrichment analysis of variants and pathways in genome-wide association studies indicates central role for IL-2 signaling genes in type 1 diabetes, and cytokine signaling genes in Crohn's disease

scientific article (publication date: 2013)

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scholarly article

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Integrated enrichment analysis of variants and pathways in genome-wide association studies indicates central role for IL-2 signaling genes in type 1 diabetes, and cytokine signaling genes in Crohn's disease (English)

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genome-wide association study

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type-1 diabetes

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Crohn's disease

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author name string

Peter Carbonetto

1

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Matthew Stephens

2

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language of work or name

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publication date

2013

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9

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10

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e1003770

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copyright license

Creative Commons Attribution 4.0 International

3 October 2013

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April 2022 Public Data File from Crossref

copyright status

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Genome-wide gene and pathway analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Etiology of type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Integrating pathway analysis and genetics of gene expression for genome-wide association studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

A variational Bayes algorithm for fast and accurate multiple locus genome-wide association analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Prioritizing GWAS results: A review of statistical methods and recommendations for their application

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Functional gene group analysis reveals a role of synaptic heterotrimeric G proteins in cognitive ability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

A pathway analysis applied to Genetic Analysis Workshop 16 genome-wide rheumatoid arthritis data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Pathway-based analysis of a genome-wide case-control association study of rheumatoid arthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Gene, region and pathway level analyses in whole-genome studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

The NCBI BioSystems database

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Bayesian statistical methods for genetic association studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Molecular networks as sensors and drivers of common human diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Gene and pathway-based second-wave analysis of genome-wide association studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

The genetics of Crohn's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Association of measles virus with rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Pathway analysis by adaptive combination of P-values

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Pathway and network-based analysis of genome-wide association studies in multiple sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Mapping complex disease traits with global gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Human immunology of measles virus infection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Genome-wide association analysis by lasso penalized logistic regression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Detecting shared pathogenesis from the shared genetics of immune-related diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Practical issues in imputation-based association mapping

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Pathways-based analyses of whole-genome association study data in bipolar disorder reveal genes mediating ion channel activity and synaptic neurotransmission

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

The immunopathogenesis of rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

GSEA-SNP: applying gene set enrichment analysis to SNP data from genome-wide association studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

High-resolution mapping of expression-QTLs yields insight into human gene regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Common variants at CD40 and other loci confer risk of rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Pathway analysis of seven common diseases assessed by genome-wide association

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Simultaneous analysis of all SNPs in genome-wide and re-sequencing association studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Bayesian LASSO for quantitative trait loci mapping

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Network-based global inference of human disease genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Defining the role of the MHC in autoimmunity: a review and pooled analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

The crucial role of IL-2/IL-2RA-mediated immune regulation in the pathogenesis of type 1 diabetes, an evidence coming from genetic and animal model studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

How to interpret a genome-wide association study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

The use of hierarchical models for estimating relative risks of individual genetic variants: an application to a study of melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Rheumatoid arthritis association at 6q23.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Imputation-based analysis of association studies: candidate regions and quantitative traits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Enriching the analysis of genomewide association studies with hierarchical modeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

New perspectives for the elucidation of genetic disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Nonreceptor protein-tyrosine phosphatases in immune cell signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Reconstruction of a functional human gene network, with an application for prioritizing positional candidate genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Gene prioritization through genomic data fusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Paths to understanding the genetic basis of autoimmune disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Gene map of the extended human MHC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

The fine-scale structure of recombination rate variation in the human genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Clustering of autoimmune disease in parents of siblings from the Type 1 diabetes Warren repository

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Cytokines and autoimmunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

MAP kinases in the immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

Chemokines in autoimmune disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

3 June 2018

A pathway analysis method for genome-wide association studies

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003770

21 January 2018

Hierarchical Bayes prioritization of marker associations from a genome-wide association scan for further investigation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003770

21 January 2018

Stochastic search gene suggestion: a Bayesian hierarchical model for gene mapping.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003770

21 January 2018

Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003770

21 January 2018

Bayesian variable and model selection methods for genetic association studies.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003770

21 January 2018

Inherited predisposition of lung cancer: a hierarchical modeling approach to DNA repair and cell cycle control pathways.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003770

21 January 2018

Implications of small effect sizes of individual genetic variants on the design and interpretation of genetic association studies of complex diseases.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003770

21 January 2018

Bayesian multivariate logistic regression

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003770

21 January 2018

Bayesian Variable Selection in Linear Regression

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003770

21 January 2018

Including known covariates can reduce power to detect genetic effects in case-control studies

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003770

21 January 2018

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003770

21 January 2018

The positive false discovery rate: a Bayesian interpretation and the q -value

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003770

21 January 2018

Evolutionary stochastic search for Bayesian model exploration

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003770

21 January 2018

Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1003770

21 January 2018

Latent Epstein-Barr virus (EBV) infection and cytomegalovirus (CMV) infection in synovial tissue of autoimmune chronic arthritis determined by RNA- and DNA-in situ hybridization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3789883

27 November 2018

Understanding type 1 diabetes through genetics: advances and prospects

1 reference

https://pubmed.ncbi.nlm.nih.gov/24098138

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetics. Robust interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/24098138

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The genetics of inflammatory bowel disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24098138

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomewide association studies--illuminating biologic pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/24098138

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PGEN.1003770

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