(Q36043724)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

title

Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

0 references

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Antony J Cutler

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Mark Peakman

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Timothy Tree

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

10

John A Todd

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

author name string

Jennifer R Tyler

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Jennie H M Yang

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Kate Downes

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Marcin Pekalski

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Gwynneth L Bell

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Sarah Nutland

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

Linda S Wicker

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

language of work or name

English

0 references

publication date

28 March 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

published in

Journal of Immunology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

volume

188

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

page(s)

4644-4653

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells

27 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

T cells in multiple sclerosis and experimental autoimmune encephalomyelitis.

2 October 2017

1 reference

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Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells

2 October 2017

1 reference

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Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk

2 October 2017

1 reference

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Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

2 October 2017

1 reference

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Apoptosis of CD4+ CD25(high) T cells in type 1 diabetes may be partially mediated by IL-2 deprivation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Analysis of islet inflammation in human type 1 diabetes.

2 October 2017

1 reference

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The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci

2 October 2017

1 reference

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The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice

2 October 2017

1 reference

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STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Interleukin-2 receptor signaling in regulatory T cell development and homeostasis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

At-risk and recent-onset type 1 diabetic subjects have increased apoptosis in the CD4+CD25+ T-cell fraction

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Tolerance, not immunity, crucially depends on IL-2.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

The role of T-cells in the pathogenesis of Type 1 diabetes: from cause to cure

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Suppressor T cells--they're back and critical for regulation of autoimmunity!

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Type-I diabetes: a chronic autoimmune disease of human, mouse, and rat.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

The T helper type 17/regulatory T cell imbalance in patients with acute Kawasaki disease.

11 July 2018

1 reference

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Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Imbalance between T helper type 17 and T regulatory cells in patients with primary biliary cirrhosis: the serum cytokine profile and peripheral cell population.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

An inverse correlation of human peripheral blood regulatory T cell frequency with the disease activity of ulcerative colitis.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

CD4+CD25high regulatory cells in human peripheral blood

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378653

Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes

21 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22461703

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Insulin-dependent diabetes mellitus

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22461703

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22461703

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4049/JIMMUNOL.1100272

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22461703%20AND%20SRC:MED&resulttype=core&format=json