(Q28910464)

7 March 2017

title

Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling (English)

1 reference

Protein kinase, DNA-activated, catalytic subunit

7 March 2017

main subject

1 reference

Poly(ADP-ribose) polymerase 1

1 reference

Interferon gamma

1 reference

X-ray repair cross complementing 6

1 reference

Tryptophanyl-tRNA synthetase 1

1 reference

X-ray repair cross complementing 5

1 reference

10

Paul Schimmel

1 reference

7 March 2017

Mathew Sajish

1

1 reference

7 March 2017

Quansheng Zhou

2

1 reference

7 March 2017

Shuji Kishi

3

1 reference

7 March 2017

Delgado M. Valdez

4

1 reference

7 March 2017

Mili Kapoor

5

1 reference

7 March 2017

Min Guo

6

1 reference

7 March 2017

Sunhee Lee

7

1 reference

7 March 2017

Sunghoon Kim

8

1 reference

7 March 2017

Xiang-Lei Yang

9

1 reference

7 March 2017

publication date

15 April 2012

1 reference

7 March 2017

published in

Nature Chemical Biology

1 reference

7 March 2017

volume

8

1 reference

7 March 2017

issue

6

1 reference

7 March 2017

page(s)

547–554

1 reference

Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats

7 March 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

LysRS serves as a key signaling molecule in the immune response by regulating gene expression

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

The identification of zebrafish mutants showing alterations in senescence-associated biomarkers

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

Functional and Crystal Structure Analysis of Active Site Adaptations of a Potent Anti-Angiogenic Human tRNA Synthetase

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

A new gamma-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

A human aminoacyl-tRNA synthetase as a regulator of angiogenesis

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

Immunoelectron microscopic location of tryptophanyl-tRNA synthetase in mammalian, prokaryotic and archaebacterial cells

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

Human interferon gamma potently induces the synthesis of a 55-kDa protein (gamma 2) highly homologous to rabbit peptide chain release factor and bovine tryptophanyl-tRNA synthetase

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

Interferon induces tryptophanyl-tRNA synthetase expression in human fibroblasts

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

An interferon-induced protein with release factor activity is a tryptophanyl-tRNA synthetase

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

New functions of aminoacyl-tRNA synthetases beyond translation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

The role of gamma interferon in innate immunity in the zebrafish embryo

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

Aminoacyl-tRNA synthesis and translational quality control

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

Kinase requirements in human cells: IV. Differential kinase requirements in cervical and renal human tumor cell lines

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

p53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

IGF-I-induced VEGF expression in HUVEC involves phosphorylation and inhibition of poly(ADP-ribose)polymerase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

Interferons as antiangiogenic agents

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

Cognition, mechanism, and evolutionary relationships in aminoacyl-tRNA synthetases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

[Immune electron microscope determination of the localization of tryptophanyl-tRNA-synthetase in bacteria and higher eukaryotes]

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3780985

Interferon-gamma induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells

20 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.937

Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.937

In vivo analysis of Ifn-γ1 and Ifn-γ2 signaling in zebrafish.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.937

Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.937

Induction of pulmonary indoleamine 2,3-dioxygenase by interferon

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.937

Induction of indoleamine 2,3-dioxygenase in mouse lung during virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.937

Mig, the monokine induced by interferon-gamma, promotes tumor necrosis in vivo

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/22504299

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

IFITM1 plays an essential role in the antiproliferative action of interferon-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22504299

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Evidence for annexin II-S100A10 complex and plasmin in mobilization of cytokine activity of human TrpRS

1 reference

https://pubmed.ncbi.nlm.nih.gov/22504299

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCHEMBIO.937

1 reference

Dimensions Publication ID

1006160405

0 references

1 reference

1 reference

1 reference