(Q29694341)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27658529%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

review article

1 reference

title

The multifaceted roles of fatty acid synthesis in cancer (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27658529%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

0 references

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27658529%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

Almut Schulze

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27658529%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

author name string

Florian Röhrig

series ordinal

1

0 references

language of work or name

English

0 references

publication date

23 September 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27658529%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

published in

Nature Reviews Cancer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27658529%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

volume

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27658529%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27658529%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

page(s)

732-749

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27658529%20AND%20SRC:MED&resulttype=core&format=json

Fatty acid synthesis: a potential selective target for antineoplastic therapy

23 March 2020

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Loss of Chromosome 8p Governs Tumor Progression and Drug Response by Altering Lipid Metabolism

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The interplay between cell signalling and the mevalonate pathway in cancer

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IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells: evidence that IDH1 may regulate lipogenesis in hepatic cells

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Activation of a metabolic gene regulatory network downstream of mTOR complex 1

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A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans

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Coordination of lipid metabolism in membrane biogenesis.

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The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

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Regulation of sterol synthesis in eukaryotes.

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

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Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase

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PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP.

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

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Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway

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mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway

31 March 2020

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The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1.

31 March 2020

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FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

31 March 2020

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Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7).

31 March 2020

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A phosphorylation cascade controls the degradation of active SREBP1.

31 March 2020

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MYC on the path to cancer

31 March 2020

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The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation

31 March 2020

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Deregulated Myc requires MondoA/Mlx for metabolic reprogramming and tumorigenesis

31 March 2020

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Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression

31 March 2020

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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

31 March 2020

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Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

31 March 2020

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Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

31 March 2020

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Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate.

31 March 2020

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Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

31 March 2020

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Fatty acid uptake and lipid storage induced by HIF-1α contribute to cell growth and survival after hypoxia-reoxygenation

31 March 2020

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Low-field magnetic resonance imaging to visualize chronic and cycling hypoxia in tumor-bearing mice

31 March 2020

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Why do cancers have high aerobic glycolysis?

31 March 2020

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Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness

31 March 2020

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Altered metabolic responses to intermittent hypoxia in mice with partial deficiency of hypoxia-inducible factor-1alpha

31 March 2020

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SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme

31 March 2020

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Delta-5 and delta-6 desaturases: crucial enzymes in polyunsaturated fatty acid-related pathways with pleiotropic influences in health and disease

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Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

31 March 2020

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Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

31 March 2020

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Intra-tumour heterogeneity - going beyond genetics.

31 March 2020

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ATP citrate lyase inhibition can suppress tumor cell growth

31 March 2020

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Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis.

31 March 2020

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Role of cardiolipin alterations in mitochondrial dysfunction and disease

31 March 2020

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Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria: lipidomic evidence supporting the Warburg theory of cancer

31 March 2020

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On the Origin of Cancer Cells

31 March 2020

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31 March 2020

Mitochondria and cancer

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p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target

31 March 2020

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Betulinic acid induces a novel cell death pathway that depends on cardiolipin modification

31 March 2020

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Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments.

31 March 2020

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Wnt signaling, stem cells, and cancer of the gastrointestinal tract

31 March 2020

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Fatty acylation of Wnt proteins

31 March 2020

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Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer.

31 March 2020

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Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.

31 March 2020

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Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins

31 March 2020

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WNT signalling pathways as therapeutic targets in cancer

31 March 2020

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Greasing their way: lipid modifications determine protein association with membrane rafts

31 March 2020

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Sphingosine 1-phosphate and cancer

31 March 2020

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Phospholipase signalling networks in cancer

31 March 2020

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Protein kinase C and other diacylglycerol effectors in cancer

31 March 2020

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PI3K signalling: the path to discovery and understanding.

31 March 2020

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Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal

31 March 2020

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LPA receptors: subtypes and biological actions

31 March 2020

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Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species

31 March 2020

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LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA)

31 March 2020

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The expression profile of phosphatidylinositol in high spatial resolution imaging mass spectrometry as a potential biomarker for prostate cancer

31 March 2020

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Cancer cells incorporate and remodel exogenous palmitate into structural and oncogenic signaling lipids

31 March 2020

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Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression

31 March 2020

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De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation

31 March 2020

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31 March 2020

Eicosanoids and cancer

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HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice.

31 March 2020

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Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice

31 March 2020

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Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade

31 March 2020

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Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.

31 March 2020

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Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.

31 March 2020

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Regulatory networks defining EMT during cancer initiation and progression

31 March 2020

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TGF-β effects on prostate cancer cell migration and invasion are mediated by PGE2 through activation of PI3K/AKT/mTOR pathway

31 March 2020

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Metabolic reprogramming during TGFβ1-induced epithelial-to-mesenchymal transition

31 March 2020

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Elevated free fatty acid uptake via CD36 promotes epithelial-mesenchymal transition in hepatocellular carcinoma

31 March 2020

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A CD36-dependent signaling cascade is necessary for macrophage foam cell formation

31 March 2020

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Candidate Antimetastasis Drugs Suppress the Metastatic Capacity of Breast Cancer Cells by Reducing Membrane Fluidity

31 March 2020

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Role of angiogenesis in tumor growth and metastasis

31 March 2020

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Lysophosphatidic acid contributes to angiogenic homeostasis

31 March 2020

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Sphingosine 1-phosphate signalling

31 March 2020

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Fatty acid carbon is essential for dNTP synthesis in endothelial cells

31 March 2020

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Fatty acid activated PPARγ promotes tumorigenicity of prostate cancer cells by up regulating VEGF via PPAR responsive elements of the promoter

31 March 2020

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From mice to humans: developments in cancer immunoediting

31 March 2020

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Regulation of immune responses by prostaglandin E2

31 March 2020

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Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

31 March 2020

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Metabolic checkpoints in activated T cells

31 March 2020

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The critical role of the tumor microenvironment in shaping natural killer cell-mediated anti-tumor immunity.

31 March 2020

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Free fatty acid release from human breast cancer tissue inhibits cytotoxic T-lymphocyte-mediated killing

31 March 2020

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NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis

31 March 2020

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Fatty Acids and Breast Cancer: Make Them on Site or Have Them Delivered

31 March 2020

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Metabolic alterations and targeted therapies in prostate cancer

31 March 2020

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Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells

31 March 2020

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Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity

31 March 2020

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Pharmacological inhibitor of fatty acid synthase suppresses growth and invasiveness of renal cancer cells

31 March 2020

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Different fatty acid metabolism effects of (-)-epigallocatechin-3-gallate and C75 in adenocarcinoma lung cancer.

31 March 2020

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Targeted therapy with fatty acid synthase inhibitors in a human prostate carcinoma LNCaP/tk-luc-bearing animal model

31 March 2020

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Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice

31 March 2020

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Green tea epigallocatechin gallate: a natural inhibitor of fatty-acid synthase

31 March 2020

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Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors

31 March 2020

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Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides

31 March 2020

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Inhibition of hypothalamic fatty acid synthase triggers rapid activation of fatty acid oxidation in skeletal muscle

31 March 2020

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Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans

31 March 2020

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Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

31 March 2020

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ATP citrate lyase is an important component of cell growth and transformation

31 March 2020

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ATP citrate lyase knockdown induces growth arrest and apoptosis through different cell- and environment-dependent mechanisms

31 March 2020

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ATP-citrate lyase links cellular metabolism to histone acetylation

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.89

Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.89

Acetate dependence of tumors

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.89

Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl-CoA/acetate metabolism

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.89

Acetate is a bioenergetic substrate for human glioblastoma and brain metastases

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.89

The metabolic fate of acetate in cancer

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.89

Acetyl-CoA carboxylase-alpha inhibitor TOFA induces human cancer cell apoptosis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.89

RNA interference-mediated silencing of the acetyl-CoA-carboxylase-alpha gene induces growth inhibition and apoptosis of prostate cancer cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.89

Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.89

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.89

Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth.

31 March 2020

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An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity

31 March 2020

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Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.89

Signaling networks converge on TORC1-SREBP activity to promote endoplasmic reticulum homeostasis.

31 March 2020

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EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.89

Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth

31 March 2020

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LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor

31 March 2020

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Uncoupling nuclear receptor LXR and cholesterol metabolism in cancer

31 March 2020

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An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway

31 March 2020

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Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

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1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Fatostatin displays high antitumor activity in prostate cancer by blocking SREBP-regulated metabolic pathways and androgen receptor signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Comprehensive review on betulin as a potent anticancer agent.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Integrated metabolite and gene expression profiles identify lipid biomarkers associated with progression of hepatocellular carcinoma and patient outcomes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Inhibition of tumor-associated fatty acid synthase hyperactivity induces synergistic chemosensitization of HER -2/ neu -overexpressing human breast cancer cells to docetaxel (taxotere).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Antiangiogenic therapy: impact on invasion, disease progression, and metastasis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Blocking lipid synthesis overcomes tumor regrowth and metastasis after antiangiogenic therapy withdrawal

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Effect of obesity on ambient plasma glucose, free fatty acid, insulin, growth hormone, and glucagon concentrations.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Late Imaging with [1-(11)C]Acetate Improves Detection of Tumor Fatty Acid Synthesis with PET.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

31 March 2020

SnapShot: Lipid Droplets

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

FAT FLUX: enzymes, regulators, and pathophysiology of intracellular lipolysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

The human peroxisome in health and disease: the story of an oddity becoming a vital organelle.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Cancer metabolism: fatty acid oxidation in the limelight

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Lipogenetic and glycolytic enzyme activities in carcinoma and nonmalignant diseases of the human breast

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Fatty acid composition of phospholipids and neutral lipids and lipid peroxidation in human breast cancer and lipoma tissue.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Hallmarks of Cancer: The Next Generation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Fatty acid synthase inhibition with Orlistat promotes apoptosis and reduces cell growth and lymph node metastasis in a mouse melanoma model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Progression of breast cancer cells was enhanced by endocrine-disrupting chemicals, triclosan and octylphenol, via an estrogen receptor-dependent signaling pathway in cellular and mouse xenograft models

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Inhibition of fatty acid metabolism reduces human myeloma cells proliferation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.89

CREB pathway links PGE2 signaling with macrophage polarization.

31 March 2020

1 reference

12 December 2020

Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP.

1 reference

12 December 2020

Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors

1 reference

12 December 2020

Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells

1 reference

12 December 2020

Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis.

1 reference

12 December 2020

Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor

1 reference

12 December 2020

Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro

1 reference

12 December 2020

Regulation of acetyl-CoA carboxylase

1 reference

12 December 2020

Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer

1 reference

12 December 2020

Selective inhibition of fatty acid synthase for lung cancer treatment

1 reference

12 December 2020

Deletion of cyclooxygenase-2 inhibits K-ras-induced lung carcinogenesis

1 reference

12 December 2020

Cycling hypoxia: A key feature of the tumor microenvironment

1 reference

12 December 2020

Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines

1 reference

12 December 2020

Validation of 18F-fluoro-4-thia-palmitate as a PET probe for myocardial fatty acid oxidation: effects of hypoxia and composition of exogenous fatty acids

1 reference

12 December 2020

Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts

1 reference

12 December 2020

Increased fatty acid synthase is a therapeutic target in mesothelioma

1 reference

12 December 2020

Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53.

1 reference

12 December 2020

Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of β-Catenin

1 reference

12 December 2020

Anti-cancer efficacy of SREBP inhibitor, alone or in combination with docetaxel, in prostate cancer harboring p53 mutations

1 reference

12 December 2020

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

1 reference

12 December 2020

Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes

1 reference

12 December 2020

Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells

1 reference

12 December 2020

Regulation of sterol regulatory-element binding protein 1 gene expression in liver: role of insulin and protein kinase B/cAkt

1 reference

12 December 2020

Inhibition of Fatty Acid Synthase (FASN) synergistically enhances the efficacy of 5-fluorouracil in breast carcinoma cells.

1 reference

12 December 2020