(Q30009530)

21 May 2017

NMR reveals the allosteric opening and closing of Abelson tyrosine kinase by ATP-site and myristoyl pocket inhibitors (English)

1 reference

21 May 2017

1 reference

Stephan Grzesiek

5

0 references

author name string

Lukasz Skora

1

1 reference

21 May 2017

Jürgen Mestan

2

1 reference

21 May 2017

Doriano Fabbro

3

1 reference

21 May 2017

Wolfgang Jahnke

4

1 reference

21 May 2017

language of work or name

English

0 references

publication date

4 November 2013

1 reference

Proceedings of the National Academy of Sciences of the United States of America

21 May 2017

1 reference

21 May 2017

110

1 reference

21 May 2017

47

1 reference

21 May 2017

E4437-45

1 reference

Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors

21 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Conformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Solution Structure of the 128 kDa Enzyme I Dimer from Escherichia coli and Its 146 kDa Complex with HPr Using Residual Dipolar Couplings and Small- and Wide-Angle X-ray Scattering

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Binding or bending: distinction of allosteric Abl kinase agonists from antagonists by an NMR-based conformational assay

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Sequential ABL kinase inhibitor therapy selects for compound drug-resistant BCR-ABL mutations with altered oncogenic potency

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Weak alignment NMR: a hawk-eyed view of biomolecular structure

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Structural basis for the autoinhibition of c-Abl tyrosine kinase

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

The Xplor-NIH NMR molecular structure determination package

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

The protein kinase complement of the human genome

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Backbone dynamics of proteins as studied by 15N inverse detected heteronuclear NMR spectroscopy: application to staphylococcal nuclease

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Overriding imatinib resistance with a novel ABL kinase inhibitor

22 May 2017

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1314712110

Signaling through dynamic linkers as revealed by PKA

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Mapping allostery through the covariance analysis of NMR chemical shifts

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Facile measurement of ¹H-¹5N residual dipolar couplings in larger perdeuterated proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

BCR-ABL SH3-SH2 domain mutations in chronic myeloid leukemia patients on imatinib

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

SH2 domains: modulators of nonreceptor tyrosine kinase activity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

From biomolecular structure to functional understanding: new NMR developments narrow the gap.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Allosteric inhibitors of Bcr-abl-dependent cell proliferation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Refinement of multidomain protein structures by combination of solution small-angle X-ray scattering and NMR data

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Regulation of the c-Abl and Bcr-Abl tyrosine kinases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

A myristoyl/phosphotyrosine switch regulates c-Abl

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

3 June 2018

Autoinhibition of c-Abl

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Triple resonance-based assignment for Abl SH(32) and its complex with a consolidated ligand.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

3 June 2018

Chronic myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

An intramolecular SH3-domain interaction regulates c-Abl activity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3839726

Inhibitors of the Abl kinase directed at either the ATP- or myristate-binding site

3 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1314712110

NMR characterization of kinase p38 dynamics in free and ligand-bound forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1314712110

Solution conformations and dynamics of ABL kinase-inhibitor complexes determined by NMR substantiate the different binding modes of imatinib/nilotinib and dasatinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1314712110

Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1314712110

Backbone NMR resonance assignment of the Abelson kinase domain in complex with imatinib.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1314712110

PRIMUS: a Windows PC-based system for small-angle scattering data analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1314712110

The Effect of Finite Sampling on the Determination of Orientational Properties: A Theoretical Treatment with Application to Interatomic Vectors in Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1314712110

TROSY-type Triple-Resonance Experiments for Sequential NMR Assignments of Large Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1314712110

Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24191057

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Dynamics in the p38alpha MAP kinase-SB203580 complex observed by liquid-state NMR spectroscopy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24191057

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24191057

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1314712110

1 reference

1728725

ADS bibcode

2013PNAS..110E4437S

0 references

1728725

1 reference

1 reference

1 reference