(Q30009939)

21 May 2017

title

Allostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner (English)

1 reference

21 May 2017

1 reference

Caleb B McDonald

1

1 reference

21 May 2017

Jimmy El Hokayem

2

1 reference

21 May 2017

Nawal Zafar

3

1 reference

21 May 2017

Jordan E Balke

4

1 reference

21 May 2017

Vikas Bhat

5

1 reference

21 May 2017

David C Mikles

6

1 reference

21 May 2017

Brian J Deegan

7

1 reference

21 May 2017

Kenneth L Seldeen

8

1 reference

21 May 2017

Amjad Farooq

9

1 reference

21 May 2017

publication date

1 February 2013

1 reference

Journal of Molecular Recognition

21 May 2017

published in

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21 May 2017

volume

26

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21 May 2017

issue

2

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21 May 2017

page(s)

92-103

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GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

21 May 2017

cites work

1 reference

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Bivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative manner

22 May 2017

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Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2

22 May 2017

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SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate manner

22 May 2017

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22 May 2017

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Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors

22 May 2017

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Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS

22 May 2017

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22 May 2017

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Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

22 May 2017

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The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif

22 May 2017

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22 May 2017

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Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses

22 May 2017

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The structural basis of the activation of Ras by Sos

22 May 2017

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CBL-GRB2 interaction in myeloid immunoreceptor tyrosine activation motif signaling

22 May 2017

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Regulation of Sos activity by intramolecular interactions

22 May 2017

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Solution structure of the Grb2 N-terminal SH3 domain complexed with a ten-residue peptide derived from SOS: direct refinement against NOEs, J-couplings and 1H and 13C chemical shifts

22 May 2017

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Mitogen-activated protein kinase pathways

22 May 2017

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Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

22 May 2017

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Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

22 May 2017

1 reference

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The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

22 May 2017

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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

22 May 2017

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Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

22 May 2017

1 reference

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Coupling of local folding to site-specific binding of proteins to DNA

22 May 2017

1 reference

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Orientation of peptide fragments from Sos proteins bound to the N-terminal SH3 domain of Grb2 determined by NMR spectroscopy

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

Crystal structure of the mammalian Grb2 adaptor

22 May 2017

1 reference

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The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells

22 May 2017

1 reference

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Rapid measurement of binding constants and heats of binding using a new titration calorimeter

22 May 2017

1 reference

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Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

22 May 2017

1 reference

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The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

22 May 2017

1 reference

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Multivalent binding and facilitated diffusion account for the formation of the Grb2-Sos1 signaling complex in a cooperative manner

22 May 2017

1 reference

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Noise in cellular signaling pathways: causes and effects

3 June 2018

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Distinct involvement of the Gab1 and Grb2 adaptor proteins in signal transduction by the related receptor tyrosine kinases RON and MET.

3 June 2018

1 reference

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Binding of the cSH3 domain of Grb2 adaptor to two distinct RXXK motifs within Gab1 docker employs differential mechanisms

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

Assembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric control

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

A new mechanism for the regulation of Gab1 recruitment to the plasma membrane.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

Structural basis of the differential binding of the SH3 domains of Grb2 adaptor to the guanine nucleotide exchange factor Sos1.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

Akt: versatile mediator of cell survival and beyond

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

p27Kip1 Inhibition of GRB2-SOS Formation Can Regulate Ras Activation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

The "Gab" in signal transduction.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

The Ras branch of small GTPases: Ras family members don't fall far from the tree

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

Structural energetics of protein folding and binding.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

Predicting binding energetics from structure: looking beyond DeltaG degrees.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

Differential interactions of the growth factor receptor-bound protein 2 N-SH3 domain with son of sevenless and dynamin. Potential role in the Ras-dependent signaling pathway

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

Structural thermodynamics: prediction of protein stability and protein binding affinities

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

Dynamin binds to SH3 domains of phospholipase C gamma and GRB-2.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

Phosphorylation modulates catalytic function and regulation in the cAMP-dependent protein kinase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

Structure of the N-terminal SH3 domain of GRB2 complexed with a peptide from the guanine nucleotide releasing factor Sos.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

Thermodynamics of structural stability and cooperative folding behavior in proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3557811

The missing term in effective pair potentials

3 June 2018

1 reference

Regulation of the mitogen-activated protein kinase signaling pathway by SHP2.

21 January 2018

1 reference

The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin

21 January 2018

1 reference

Grb2 adaptor undergoes conformational change upon dimerization

21 January 2018

1 reference

Molecular-dynamics study of atomic motions in water

21 January 2018

1 reference

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

21 January 2018

1 reference

Protein Identification and Analysis Tools on the ExPASy Server

21 January 2018

1 reference

Molecular basis of cooperativity in protein folding. V. Thermodynamic and structural conditions for the stabilization of compact denatured states

21 January 2018

1 reference

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https://pubmed.ncbi.nlm.nih.gov/23334917