(Q30336116)

19 June 2017

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title

Protein structure similarity as guiding principle for combinatorial library design. (English)

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19 June 2017

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2

Rolf Breinbauer

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19 June 2017

Herbert Waldmann

3

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author name string

Marcus A Koch

series ordinal

1

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19 June 2017

1 September 2003

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19 June 2017

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19 June 2017

384

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19 June 2017

9

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19 June 2017

1265-1272

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Can we learn to distinguish between "drug-like" and "nondrug-like" molecules?

19 June 2017

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Chemical genetic approaches for the elucidation of signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Emergence of diverse biochemical activities in evolutionarily conserved structural scaffolds of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Discovery of Carbohydrate Sulfotransferase Inhibitors from a Kinase-Directed Library We thank Sharon Long and Dave Keating for providing both the NodH sulfotransferase and APS Kinase during our preliminary experiments and Jack Kirsch for [...]

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

The art and practice of structure-based drug design: A molecular modeling perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

From protein domains to drug candidates-natural products as guiding principles in the design and synthesis of compound libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Natural products are biologically validated starting points in structural space for compound library development: solid-phase synthesis of dysidiolide-derived phosphatase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Chemogenomic approaches to drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

A potent and highly selective sulfotransferase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

One thousand families for the molecular biologist

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

From protein sequence to function

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Divergent evolution of enzymatic function: mechanistically diverse superfamilies and functionally distinct suprafamilies

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Lead compounds discovered from libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Ancient conserved regions in new gene sequences and the protein databases

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Unification of protein families.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Crystal structure of estrogen sulphotransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

The sulfuryl transfer mechanism. Crystal structure of a vanadate complex of estrogen sulfotransferase and mutational analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

The structure of the protein universe and genome evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Scaffold architecture and pharmacophoric properties of natural products and trade drugs: application in the design of natural product-based combinatorial libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

How far divergent evolution goes in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Evolution of domain families

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Supersites within superfolds. Binding site similarity in the absence of homology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

A scoring scheme for discriminating between drugs and nondrugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Total synthesis and biological evaluation of the nakijiquinones

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Natural product derived receptor tyrosine kinase inhibitors: identification of IGF1R, Tie-2, and VEGFR-3 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Chemical genetics: ligand-based discovery of gene function

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

The COG database: new developments in phylogenetic classification of proteins from complete genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Protein folds: towards understanding folding from inspection of native structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Evolution of protein function, from a structural perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Discovery of estrogen sulfotransferase inhibitors from a purine library screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Recognizing molecules with drug-like properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Combinatorial synthesis of 3-(amidoalkyl) and 3-(aminoalkyl)-2-arylindole derivatives: discovery of potent ligands for a variety of G-protein coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

Estimating the number of protein folds and families from complete genome data

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2003.140

21 January 2018

Identifiers

DOI

10.1515/BC.2003.140

1 reference

19 June 2017

1 reference

PubMed ID

14515987