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Why does the Ras switch "break" by oncogenic mutations?

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Europe PubMed Central

19 June 2017

Why does the Ras switch "break" by oncogenic mutations? (English)

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Europe PubMed Central

19 June 2017

2

Arieh Warshel

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Europe PubMed Central

19 June 2017

Avital Shurki

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Europe PubMed Central

PubMed ID

14997535

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19 June 2017

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English

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1 April 2004

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Europe PubMed Central

19 June 2017

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Europe PubMed Central

19 June 2017

55

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Europe PubMed Central

19 June 2017

1-10

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Europe PubMed Central

19 June 2017

1

1 reference

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Europe PubMed Central

19 June 2017

Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity

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https://api.crossref.org/works/10.1002%2FPROT.20004

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21 January 2018

The GTPase superfamily: conserved structure and molecular mechanism

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A new method for predicting binding affinity in computer-aided drug design

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The arginine finger of RasGAP helps Gln-61 align the nucleophilic water in GAP-stimulated hydrolysis of GTP.

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11 October 2022

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Electrostatic control of GTP and GDP binding in the oncoprotein p21ras

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11 October 2022

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1 reference

11 October 2022

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Function and regulation of ras.

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11 October 2022

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Calculation of free‐energy differences from computer simulations of initial and final states

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/PROT.20004

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/PROT.20004

Probing the structure and mechanism of Ras protein with an expanded genetic code

1 reference

11 October 2022

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Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/PROT.20004

G protein mechanisms: insights from structural analysis

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RanGAP mediates GTP hydrolysis without an arginine finger

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11 October 2022

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Calculations of antibody-antigen interactions: microscopic and semi-microscopic evaluation of the free energies of binding of phosphorylcholine analogs to McPC603

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On the mechanism of guanosine triphosphate hydrolysis in ras p21 proteins

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11 October 2022

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Linear free energy relationships in the intrinsic and GTPase activating protein-stimulated guanosine 5'-triphosphate hydrolysis of p21ras.

1 reference

11 October 2022

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The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

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11 October 2022

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Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins.

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How does GAP catalyze the GTPase reaction of Ras? A computer simulation study

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Substrate assisted catalysis -- application to G proteins.

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11 October 2022

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Enzymatic GTP hydrolysis: insights from an ab initio molecular dynamics study

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/PROT.20004

How important are entropic contributions to enzyme catalysis?

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11 October 2022

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Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

1 reference

11 October 2022

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Computer simulations of enzyme catalysis: methods, progress, and insights

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/PROT.20004

Identifiers

DOI

10.1002/PROT.20004

1 reference

stated in

Europe PubMed Central

19 June 2017

1 reference

Europe PubMed Central

PubMed ID

14997535

retrieved

19 June 2017

ResearchGate publication ID

8680022

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(Q30339075)

Why does the Ras switch "break" by oncogenic mutations?

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