(Q46059326)

19 December 2017

title

Electrostatic control of GTP and GDP binding in the oncoprotein p21ras (English)

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19 December 2017

4

A Warshel

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19 December 2017

author name string

I Muegge

series ordinal

1

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19 December 2017

T Schweins

series ordinal

2

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19 December 2017

R Langen

series ordinal

3

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19 December 2017

language of work or name

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1 April 1996

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19 December 2017

published in

Structure

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19 December 2017

volume

4

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19 December 2017

page(s)

475-489

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19 December 2017

issue

4

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19 December 2017

The GTPase superfamily: a conserved switch for diverse cell functions

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A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants

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Proteins regulating Ras and its relatives

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On the mechanism of guanosine triphosphate hydrolysis in ras p21 proteins

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7 January 2021

Why have mutagenesis studies not located the general base in ras p21.

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7 January 2021

Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins.

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7 January 2021

The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway.

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Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras

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The Kinetic Mechanism of Ran-Nucleotide Exchange Catalyzed by RCC1

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7 January 2021

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

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7 January 2021

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

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7 January 2021

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

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7 January 2021

Crystal structure of an active form of RAS protein, a complex of a GTP analog and the HRAS p21 catalytic domain

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7 January 2021

Calculations of antibody-antigen interactions: microscopic and semi-microscopic evaluation of the free energies of binding of phosphorylcholine analogs to McPC603

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7 January 2021

On the interpretation of biochemical data by molecular dynamics computer simulation

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7 January 2021

Dipoles localized at helix termini of proteins stabilize charges

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7 January 2021

GTP-binding proteins. Structures, interactions and relationships

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Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras.

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Preferential inhibition of the oncogenic form of RasH by mutations in the GAP binding/"effector" domain

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7 January 2021

Probing the role of loop 2 in Ras function with unnatural amino acids

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7 January 2021

Biological and biochemical properties of human rasH genes mutated at codon 61.

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7 January 2021

Two types of RAS mutants that dominantly interfere with activators of RAS.

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7 January 2021

Mutagenesis of the H-ras p21 at glycine-60 residue disrupts GTP-induced conformational change

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7 January 2021

Identification of residues of the H-ras protein critical for functional interaction with guanine nucleotide exchange factors

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7 January 2021

Switching nucleotide specificity of Ha-Ras p21 by a single amino acid substitution at aspartate 119.

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7 January 2021

Relationship among guanine nucleotide exchange, GTP hydrolysis, and transforming potential of mutated ras proteins

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7 January 2021

Electrostatic Energy and Macromolecular Function

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7 January 2021

Effect of the Asn52----Ile mutation on the redox potential of yeast cytochrome c. Theory and experiment

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7 January 2021

Why ion pair reversal by protein engineering is unlikely to succeed

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7 January 2021

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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7 January 2021

Identification of a nucleotide exchange-promoting activity for p21ras

1 reference

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7 January 2021

Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae

1 reference

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7 January 2021

RAS residues that are distant from the GDP binding site play a critical role in dissociation factor-stimulated release of GDP

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2896%2900052-4

7 January 2021

Identification of residues critical for Ras(17N) growth-inhibitory phenotype and for Ras interaction with guanine nucleotide exchange factors

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7 January 2021

Biological properties of human c-Ha-ras1 genes mutated at codon 12.

1 reference

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7 January 2021

Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity

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7 January 2021

Probing the structure and mechanism of Ras protein with an expanded genetic code

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7 January 2021

10.1016/S0969-2126(96)00052-4

Identifiers

DOI

1 reference

19 December 2017

PubMed ID

8740369

1 reference

19 December 2017