(Q30373969)

21 June 2017

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title

Individualization of treatments with drugs metabolized by CES1: combining genetics and metabolomics. (English)

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21 June 2017

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6

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Søren Brunak

10

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Thomas Werge

19

Thomas Werge

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21 June 2017

8

Rima Kaddurah-Daouk

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Anne Katrine Pagsberg

Anne Katrine Pagsberg

13

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Pia Jeppesen

Pia Jeppesen

12

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Kristian Linnet

Kristian Linnet

3

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Poul Erik Hansen

Poul Erik Hansen

17

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Thomas Hankemeier

7

Thomas Hankemeier

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21 June 2017

author name string

Henrik Berg Rasmussen

1

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21 June 2017

Ditte Bjerre

2

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21 June 2017

Gesche Jürgens

4

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21 June 2017

Kim Dalhoff

5

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21 June 2017

Olivier Taboureau

9

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21 June 2017

Tine Houmann

11

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21 June 2017

Kerstin Plessen

14

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21 June 2017

Jørgen Dyrborg

15

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21 June 2017

Peter Riis Hansen

16

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21 June 2017

Tim Hughes

18

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21 June 2017

INDICES Consortium

20

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21 June 2017

publication date

21 April 2015

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21 June 2017

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21 June 2017

volume

16

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21 June 2017

issue

6

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21 June 2017

page(s)

649-665

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Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs

21 June 2017

cites work

1 reference

21 January 2018

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Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1.

21 January 2018

1 reference

Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel.

21 January 2018

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Hydrolytic profile for ester- or amide-linkage by carboxylesterases pI 5.3 and 4.5 from human liver

21 January 2018

1 reference

Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril

21 January 2018

1 reference

Involvement of carboxylesterase 1 and 2 in the hydrolysis of mycophenolate mofetil

21 January 2018

1 reference

Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: a potential role in adipocyte lipolysis

21 January 2018

1 reference

Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2

21 January 2018

1 reference

Association of carboxylesterase 1A genotypes with irinotecan pharmacokinetics in Japanese cancer patients

21 January 2018

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Pharmacogenomic assessment of carboxylesterases 1 and 2

21 January 2018

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Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity

21 January 2018

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Activation of the antiviral prodrug oseltamivir is impaired by two newly identified carboxylesterase 1 variants

21 January 2018

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Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis

21 January 2018

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Genomic structure and transcriptional regulation of the rat, mouse, and human carboxylesterase genes

21 January 2018

1 reference

Structure and characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes.

21 January 2018

1 reference

The sequence and analysis of duplication-rich human chromosome 16

21 January 2018

1 reference

Human carboxylesterase 1A2 expressed from carboxylesterase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro

21 January 2018

1 reference

Functional polymorphisms in carboxylesterase1A2 (CES1A2) gene involves specific protein 1 (Sp1) binding sites.

21 January 2018

1 reference

A discriminative analytical method for detection of CES1A1 and CES1A2/CES1A3 genetic variants

21 January 2018

1 reference

Influence of ethanol and gender on methylphenidate pharmacokinetics and pharmacodynamics

21 January 2018

1 reference

Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation

21 January 2018

1 reference

Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme

21 January 2018

1 reference

The alpha/beta hydrolase fold

21 January 2018

1 reference

Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1.

21 January 2018

1 reference

Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil

21 January 2018

1 reference

Evolved to be active: sulfate ions define substrate recognition sites of CK2alpha and emphasise its exceptional role within the CMGC family of eukaryotic protein kinases

21 January 2018

1 reference

Crystal structure at 1.9 A resolution of the apoovotransferrin N-lobe bound by sulfate anions: implications for the domain opening and iron release mechanism.

21 January 2018

1 reference

Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids

21 January 2018

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Identification of the cytosolic carboxylesterase catalyzing the 5'-deoxy-5-fluorocytidine formation from capecitabine in human liver

21 January 2018

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Different inhibitory effects in rat and human carboxylesterases.

21 January 2018

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Simultaneous absolute protein quantification of carboxylesterases 1 and 2 in human liver tissue fractions using liquid chromatography-tandem mass spectrometry

21 January 2018

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Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol

21 January 2018

1 reference

Pharmacotherapy of epilepsy: newly approved and developmental agents

21 January 2018

1 reference

Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide.

21 January 2018

1 reference

DrugBank: a comprehensive resource for in silico drug discovery and exploration

21 January 2018

1 reference

DrugBank: a knowledgebase for drugs, drug actions and drug targets

21 January 2018

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DrugBank 3.0: a comprehensive resource for 'omics' research on drugs

21 January 2018

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Drug-induced angioedema without urticaria

21 January 2018

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The epidemiology of psychotropic drug use in children and adolescents.

21 January 2018

1 reference

Diagnosis and management of attention-deficit/hyperactivity disorder in children, young people, and adults: summary of NICE guidance

21 January 2018

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Attention-deficit hyperactivity disorder: recent advances in paediatric pharmacotherapy

21 January 2018

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ADHD: current and future therapeutics

21 January 2018

1 reference

Methylphenidate for the treatment of apathy in Alzheimer disease: prediction of response using dextroamphetamine challenge

21 January 2018

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The use of dopaminergic and stimulant drugs for the treatment of depression

21 January 2018

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Methylphenidate for freezing of gait in Parkinson's disease.

21 January 2018

1 reference

21 January 2018

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Comparing the efficacy of stimulants for ADHD in children and adolescents using meta-analysis

21 January 2018

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Impairment and deportment responses to different methylphenidate doses in children with ADHD: the MTA titration trial

21 January 2018

1 reference

Methylphenidate dosage for children with ADHD over time under controlled conditions: lessons from the MTA.

21 January 2018

1 reference

Psychiatric pharmacogenetics: personalizing psychostimulant therapy in attention-deficit/hyperactivity disorder

21 January 2018

1 reference

Pharmacotherapy of attention-deficit/hyperactivity disorder: nonstimulant medication approaches.

21 January 2018

1 reference

Plasma level-dependent effects of methylphenidate on task-related functional magnetic resonance imaging signal changes.

21 January 2018

1 reference

Learning ability and methylphenidate (Ritalin) plasma concentration in hyperkinetic children. A preliminary investigation.

21 January 2018

1 reference

Attention deficit disorder with hyperactivity and methylphenidate: the effects of dose and mastery level on children's learning performance.

21 January 2018

1 reference

A dose-response study of OROS methylphenidate in children with attention-deficit/hyperactivity disorder

21 January 2018

1 reference

Pharmacokinetics of methylphenidate in hyperkinetic children

21 January 2018

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Pharmacogenetics of methylphenidate response in attention deficit/hyperactivity disorder: association with the dopamine transporter gene (SLC6A3).

21 January 2018

1 reference

Roles of the two active sites of somatic angiotensin-converting enzyme in the cleavage of angiotensin I and bradykinin: insights from selective inhibitors

21 January 2018

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In vitro drug metabolism by human carboxylesterase 1: focus on angiotensin-converting enzyme inhibitors

21 January 2018

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Variability in response to antihypertensive drugs

21 January 2018

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Dose-dependent antihypertensive efficacy and tolerability of perindopril in a large, observational, 12-week, general practice-based study

21 January 2018

1 reference

Genetic tailoring of pharmacotherapy in heart failure: optimize the old, while we wait for something new.

21 January 2018

1 reference

Comparative pharmacokinetics and pharmacodynamics of platelet adenosine diphosphate receptor antagonists and their clinical implications

21 January 2018

1 reference

A possible mechanism for the differences in efficiency and variability of active metabolite formation from thienopyridine antiplatelet agents, prasugrel and clopidogrel.

21 January 2018

1 reference

Clopidogrel nonresponsiveness in patients undergoing percutaneous coronary intervention with stenting: a systematic review and meta-analysis.

21 January 2018

1 reference

Clopidogrel loading dose and bleeding outcomes in patients undergoing urgent coronary artery bypass grafting.

21 January 2018

1 reference

The pharmacogenetics of antiplatelet agents: towards personalized therapy?

21 January 2018

1 reference

The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response

21 January 2018

1 reference

Oseltamivir in seasonal, pandemic, and avian influenza: a comprehensive review of 10-years clinical experience

21 January 2018

1 reference

Neuraminidase inhibitors for influenza

21 January 2018

1 reference

Clinical pharmacokinetics of the prodrug oseltamivir and its active metabolite Ro 64-0802.

21 January 2018

1 reference

The pharmacokinetics and tolerability of the oral neuraminidase inhibitor oseltamivir (Ro 64-0796/GS4104) in healthy adult and elderly volunteers.

21 January 2018

1 reference

Oseltamivir in seasonal, avian H5N1 and pandemic 2009 A/H1N1 influenza: pharmacokinetic and pharmacodynamic characteristics.

21 January 2018

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21 January 2018

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Pharmacologic considerations for oseltamivir disposition: focus on the neonate and young infant

21 January 2018

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Pharmacokinetics of high-dose oseltamivir in healthy volunteers

21 January 2018

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Safety and pharmacology of oseltamivir in clinical use.

21 January 2018

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Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2.

21 January 2018

1 reference

Lipopolysaccharide down-regulates carbolesterases 1 and 2 and reduces hydrolysis activity in vitro and in vivo via p38MAPK-NF-κB pathway

21 January 2018

1 reference

Clinical pharmacokinetics and pharmacodynamics of mycophenolate in solid organ transplant recipients

21 January 2018

1 reference

Immunosuppressive therapies in myasthenia gravis

21 January 2018

1 reference

Clinical pharmacokinetics of mycophenolate mofetil

21 January 2018

1 reference

C-440T/T-331C polymorphisms in the UGT1A9 gene affect the pharmacokinetics of mycophenolic acid in kidney transplantation

21 January 2018

1 reference

The impact of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T on early mycophenolic acid dose-interval exposure in de novo renal allograft recipients

21 January 2018

1 reference

Rufinamide: clinical pharmacokinetics and concentration-response relationships in patients with epilepsy

21 January 2018

1 reference

Oxybutynin for treatment of urge urinary incontinence and overactive bladder: an updated review

21 January 2018

1 reference

The pharmacokinetics of oxybutynin in man

21 January 2018

1 reference

Allosteric kinetics of human carboxylesterase 1: species differences and interindividual variability.

21 January 2018

1 reference

Activity-based protein profiling identifies a host enzyme, carboxylesterase 1, which is differentially active during hepatitis C virus replication

21 January 2018

1 reference

Inhibition of carboxylesterase 1 is associated with cholesteryl ester retention in human THP-1 monocyte/macrophages.

21 January 2018

1 reference

Triacylglycerol hydrolase: role in intracellular lipid metabolism

21 January 2018

1 reference

Purification, cloning, and expression of a human enzyme with acyl coenzyme A: cholesterol acyltransferase activity, which is identical to liver carboxylesterase

21 January 2018

1 reference

Control of RhoA methylation by carboxylesterase I

21 January 2018

1 reference

Human egasyn binds beta-glucuronidase but neither the esterase active site of egasyn nor the C terminus of beta-glucuronidase is involved in their interaction

21 January 2018

1 reference

Comparative proteomic analysis of lung lamellar bodies and lysosome-related organelles

21 January 2018

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A dysregulation in CES1, APOE and other lipid metabolism-related genes is associated to cardiovascular risk factors linked to obesity

21 January 2018

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Depot-specific expression of lipolytic genes in human adipose tissues--association among CES1 expression, triglyceride lipase activity and adiposity.

21 January 2018

1 reference

Loss of TGH/Ces3 in mice decreases blood lipids, improves glucose tolerance, and increases energy expenditure

21 January 2018

1 reference

Carboxylesterase: specificity and spontaneous reactivation of an endogenous scavenger for organophosphorus compounds

21 January 2018

1 reference

Extremely sensitive biomarker of acute organophosphorus insecticide exposure

21 January 2018

1 reference

Innovation: Metabolomics: the apogee of the omics trilogy

21 January 2018

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Metabolomics: a global biochemical approach to drug response and disease

21 January 2018

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Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

21 January 2018

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Allosteric activation of cytochrome P450 3A4 by α-naphthoflavone: branch point regulation revealed by isotope dilution analysis

21 January 2018

1 reference

Evaluation of endogenous metabolic markers of hepatic CYP3A activity using metabolic profiling and midazolam clearance.

21 January 2018

1 reference

Detection of an endogenous urinary biomarker associated with CYP2D6 activity using global metabolomics

21 January 2018

1 reference

Genetic variation in rates of antipyrine metabolite formation: a study in uninduced twins

21 January 2018

1 reference

The interindividual differences in the 3-demthylation of caffeine alias CYP1A2 is determined by both genetic and environmental factors

21 January 2018

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Prediction of variability in CYP3A4 induction using a combined 1H NMR metabonomics and targeted UPLC-MS approach.

21 January 2018

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21 January 2018

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Regulation of carboxylesterase 1 (CES1) in human adipose tissue

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/PGS.15.7

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21 June 2017

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