(Q30386079)

21 June 2017

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title

The sour side of neurodegenerative disorders: the effects of protein glycation. (English)

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21 June 2017

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1

Hugo Vicente Miranda

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21 June 2017

Tiago Fleming Outeiro

series ordinal

2

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PubMed ID

20186922

21 June 2017

language of work or name

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1 May 2010

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21 June 2017

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21 June 2017

221

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21 June 2017

1

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21 June 2017

13-25

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Demography. Broken limits to life expectancy

21 June 2017

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Unifying features of systemic and cerebral amyloidosis

21 January 2018

1 reference

Alpha-synuclein in Lewy bodies

21 January 2018

1 reference

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

1 reference

Transthyretin mutations in hyperthyroxinemia and amyloid diseases

21 January 2018

1 reference

Advanced glycation end-products (AGEs) and heart failure: pathophysiology and clinical implications

21 January 2018

1 reference

Advanced glycosylation: chemistry, biology, and implications for diabetes and aging

21 January 2018

1 reference

Advanced glycation: an important pathological event in diabetic and age related ocular disease

21 January 2018

1 reference

Advanced glycation endproducts--role in pathology of diabetic complications

21 January 2018

1 reference

Accumulation of Maillard reaction products in skin collagen in diabetes and aging

21 January 2018

1 reference

The clinical relevance of assessing advanced glycation endproducts accumulation in diabetes

21 January 2018

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Clinical relevance of advanced glycation endproducts for vascular surgery

21 January 2018

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Further identification of the nature and linkage of the carbohydrate in hemoglobin A1c

21 January 2018

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Nonenzymatic glycosylation and the pathogenesis of diabetic complications

21 January 2018

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Role of fructose in glycation and cross-linking of proteins

21 January 2018

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Methylglyoxal, glyoxalases and the development of diabetic complications

21 January 2018

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Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification--a role in pathogenesis and antiproliferative chemotherapy.

21 January 2018

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Methylglyoxal, oxidative stress, and hypertension

21 January 2018

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Mechanism for the formation of methylglyoxal from triosephosphates

21 January 2018

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Molecular identity and cellular distribution of advanced glycation endproduct receptors: relationship of p60 to OST-48 and p90 to 80K-H membrane proteins.

21 January 2018

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The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses

21 January 2018

1 reference

Receptor for Advanced Glycation Endproducts (RAGE): a formidable force in the pathogenesis of the cardiovascular complications of diabetes & aging

21 January 2018

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Receptor for advanced glycation end products (AGEs) has a central role in vessel wall interactions and gene activation in response to circulating AGE proteins

21 January 2018

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Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of dia

21 January 2018

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Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. Soluble receptor for advanced glycation end products blocks hyperpermeability in diabetic rats

21 January 2018

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Advanced protein glycosylation induces transendothelial human monocyte chemotaxis and secretion of platelet-derived growth factor: role in vascular disease of diabetes and aging.

21 January 2018

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Advanced glycation end product-induced apoptosis and overexpression of vascular endothelial growth factor and monocyte chemoattractant protein-1 in human-cultured mesangial cells

21 January 2018

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Receptor-specific induction of insulin-like growth factor I in human monocytes by advanced glycosylation end product-modified proteins

21 January 2018

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Mechanisms involved in the stimulatory effect of advanced glycation end products on growth of rat aortic smooth muscle cells

21 January 2018

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Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB

21 January 2018

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N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression

21 January 2018

1 reference

The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment

21 January 2018

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Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1.

21 January 2018

1 reference

Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum

21 January 2018

1 reference

Recent insights into the molecular genetics of dementia

21 January 2018

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Synapse Formation and Function Is Modulated by the Amyloid Precursor Protein

21 January 2018

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Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

21 January 2018

1 reference

Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms.

21 January 2018

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Aberrant tau phosphorylation by glycogen synthase kinase-3beta and JNK3 induces oligomeric tau fibrils in COS-7 cells.

21 January 2018

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Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

21 January 2018

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Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

21 January 2018

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ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

21 January 2018

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Advanced glycation end products contribute to amyloidosis in Alzheimer disease

21 January 2018

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Advanced Maillard reaction end products are associated with Alzheimer disease pathology

21 January 2018

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Pseudophosphorylation and glycation of tau protein enhance but do not trigger fibrillization in vitro

21 January 2018

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Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide.

21 January 2018

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Methylglyoxal induces apoptosis through activation of p38 mitogen-activated protein kinase in rat mesangial cells

21 January 2018

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Phosphorylation Sites on Tau Identified by Nanoelectrospray Mass Spectrometry

21 January 2018

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Potential inplications of endogenous aldehydes in beta-amyloid misfolding, oligomerization and fibrillogenesis.

21 January 2018

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Age- and stage-dependent glyoxalase I expression and its activity in normal and Alzheimer's disease brains

21 January 2018

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Therapy Insight: type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease

21 January 2018

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Glyceraldehyde-derived advanced glycation end products in Alzheimer's disease

21 January 2018

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Toxic advanced glycation end products (TAGE) theory in Alzheimer's disease

21 January 2018

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Involvement of advanced glycation end-products (AGEs) in Alzheimer's disease

21 January 2018

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A tombstone in Alzheimer's?

21 January 2018

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In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification.

21 January 2018

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Age- and stage-dependent accumulation of advanced glycation end products in intracellular deposits in normal and Alzheimer's disease brains.

21 January 2018

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Glycation and microglial reaction in lesions of Alzheimer's disease.

21 January 2018

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Neurotoxicity of advanced glycation end-products for cultured cortical neurons

21 January 2018

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Immunohistochemical distribution of the receptor for advanced glycation end products in neurons and astrocytes in Alzheimer's disease.

21 January 2018

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Incidence of Parkinson's disease: variation by age, gender, and race/ethnicity

21 January 2018

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alpha-Synuclein and Parkinson's disease.

21 January 2018

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Staging of brain pathology related to sporadic Parkinson's disease

21 January 2018

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Overexpression of human alpha-synuclein causes dopamine neuron death in primary human mesencephalic culture

21 January 2018

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Impact of recent genetic findings in Parkinson's disease

21 January 2018

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Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions

21 January 2018

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Does oxidative stress participate in nerve cell death in Parkinson's disease?

21 January 2018

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Lipid binding inhibits alpha-synuclein fibril formation

21 January 2018

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The biochemistry of Parkinson's disease

21 January 2018

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Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

21 January 2018

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Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease.

21 January 2018

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Evidence of oxidative stress in the neocortex in incidental Lewy body disease

21 January 2018

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Glutathione-dependent detoxification of alpha-oxoaldehydes by the glyoxalase system: involvement in disease mechanisms and antiproliferative activity of glyoxalase I inhibitors.

21 January 2018

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The modification of alpha-synuclein by dicarbonyl compounds inhibits its fibril-forming process

21 January 2018

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Trends in the molecular pathogenesis and clinical therapeutics of common neurodegenerative disorders

21 January 2018

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Genetics of familial and sporadic amyotrophic lateral sclerosis

21 January 2018

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Molecular biology of amyotrophic lateral sclerosis: insights from genetics

21 January 2018

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Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations.

21 January 2018

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Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease.

21 January 2018

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TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor

21 January 2018

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Selective formation of certain advanced glycation end products in spinal cord astrocytes of humans and mice with superoxide dismutase-1 mutation

21 January 2018

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Central role of RAGE-dependent neointimal expansion in arterial restenosis

21 January 2018

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RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy

21 January 2018

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The advanced glycation end-product N epsilon-(carboxymethyl)lysine level is elevated in cerebrospinal fluid of patients with amyotrophic lateral sclerosis

21 January 2018

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A peculiar form of peripheral neuropathy; familiar atypical generalized amyloidosis with special involvement of the peripheral nerves

21 January 2018

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Retinol-binding protein: the transport protein for vitamin A in human plasma

21 January 2018

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Amyloid fibril protein related to prealbumin in familial amyloidotic polyneuropathy

21 January 2018

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Fibril in senile systemic amyloidosis is derived from normal transthyretin

21 January 2018

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Argpyrimidine, a methylglyoxal-derived advanced glycation end-product in familial amyloidotic polyneuropathy.

21 January 2018

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Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathways

21 January 2018

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Prions as adaptive conduits of memory and inheritance

21 January 2018

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Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal

21 January 2018

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Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils

21 January 2018

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21 January 2018

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The controversial protein-only hypothesis of prion propagation.

21 January 2018

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Imbalance of antioxidant defense in mice lacking cellular prion protein.

21 January 2018

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Impairment of superoxide dismutase activation by N-terminally truncated prion protein (PrP) in PrP-deficient neuronal cell line

21 January 2018

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Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding

21 January 2018

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Advanced glycation end products (AGE) and their receptor (RAGE) in the brain of patients with Creutzfeldt-Jakob disease with prion plaques.

21 January 2018

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Nonenzymatic glycation at the N terminus of pathogenic prion protein in transmissible spongiform encephalopathies

21 January 2018

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Methylglyoxal in living organisms: chemistry, biochemistry, toxicology and biological implications

21 January 2018

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Diagnosis of cell death induced by methylglyoxal, a metabolite derived from glycolysis, in Saccharomyces cerevisiae.

21 January 2018

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Kinetics and mechanism of the reaction of aminoguanidine with the alpha-oxoaldehydes glyoxal, methylglyoxal, and 3-deoxyglucosone under physiological conditions.

21 January 2018

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The carbonyl scavengers aminoguanidine and tenilsetam protect against the neurotoxic effects of methylglyoxal

21 January 2018

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Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase

21 January 2018

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Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo

21 January 2018

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Fructosamine 3-kinase is involved in an intracellular deglycation pathway in human erythrocytes

21 January 2018

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Fructosamine 3-kinase-related protein and deglycation in human erythrocytes

21 January 2018

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Molecular cloning and expression of amadoriase isoenzyme (fructosyl amine:oxygen oxidoreductase, EC 1.5.3) from Aspergillus fumigatus

21 January 2018

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Identification of a pathway for the utilization of the Amadori product fructoselysine in Escherichia coli

21 January 2018

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Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases

21 January 2018

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Evidence for the formation of adducts and S-(carboxymethyl)cysteine on reaction of alpha-dicarbonyl compounds with thiol groups on amino acids, peptides, and proteins

21 January 2018

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Inactivation of cellular enzymes by carbonyls and protein-bound glycation/glycoxidation products

21 January 2018

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Glycation-induced inactivation and loss of antigenicity of catalase and superoxide dismutase

21 January 2018

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Protein glycation in vivo: functional and structural effects on yeast enolase.

21 January 2018

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Enhancement of chaperone function of alpha-crystallin by methylglyoxal modification

21 January 2018

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Effect of methylglyoxal modification and phosphorylation on the chaperone and anti-apoptotic properties of heat shock protein 27.

21 January 2018

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Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers.

21 January 2018

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Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

21 January 2018

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Production of the Alzheimer amyloid beta protein by normal proteolytic processing

21 January 2018

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Genetics of Parkinson's disease and biochemical studies of implicated gene products: Commentary

21 January 2018

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The amyloidogenic potential of transthyretin variants correlates with their tendency to aggregate in solution

21 January 2018

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The Tetrameric Protein Transthyretin Dissociates to a Non-native Monomer in Solution

21 January 2018

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Tetramer Dissociation and Monomer Partial Unfolding Precedes Protofibril Formation in Amyloidogenic Transthyretin Variants

21 January 2018

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Advanced glycation end product in familial amyloidotic polyneuropathy (FAP)

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/PATH.2682

1 reference

21 June 2017

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PubMed ID

20186922