(Q30424937)

English

Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway

scientific article published on 28 July 2011

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Src homology domain 2-containing protein-tyrosine phosphatase-1 (SHP-1) binds and dephosphorylates G(alpha)-interacting, vesicle-associated protein (GIV)/Girdin and attenuates the GIV-phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway (English)

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

author name string

Yash Mittal

1

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Yelena Pavlova

2

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Mikel Garcia-Marcos

3

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Pradipta Ghosh

4

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

language of work or name

0 references

publication date

28 July 2011

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

286

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

37

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

32404-32415

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

Tyrosine phosphorylation of the Gα-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Expression of GIV/Girdin, a metastasis‐related protein, predicts patient survival in colon cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Role of the protein tyrosine phosphatase SHP‐1 in Interleukin‐6 regulation of prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

A G{alpha}i-GIV molecular complex binds epidermal growth factor receptor and determines whether cells migrate or proliferate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Central neuroinvasion and demyelination by inflammatory macrophages after peripheral virus infection is controlled by SHP-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Immunohistochemical detection of tyrosine phosphatase SHP-1 predicts outcome after radical prostatectomy for localized prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Interplay between the heterotrimeric G-protein subunits Galphaq and Galphai2 sets the threshold for chemotaxis and TCR activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

GIV is a nonreceptor GEF for G alpha i with a unique motif that regulates Akt signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Activation of Galphai3 triggers cell migration via regulation of GIV.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

An actin-binding protein Girdin regulates the motility of breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Girdin, a novel actin-binding protein, and its family of proteins possess versatile functions in the Akt and Wnt signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

The scaffolding adapter Gab1 mediates vascular endothelial growth factor signaling and is required for endothelial cell migration and capillary formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Modulation of alpha-catenin Tyr phosphorylation by SHP2 positively effects cell transformation induced by the constitutively active FGFR3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Akt/PKB regulates actin organization and cell motility via Girdin/APE

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

The tyrosine phosphatase, SHP-1, is a negative regulator of endothelial superoxide formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Phosphatidylinositol phosphate kinase type Igamma directly associates with and regulates Shp-1 tyrosine phosphatase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Identification and characterization of GIV, a novel Galpha i/s-interacting protein found on COPI, endoplasmic reticulum-Golgi transport vesicles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Localization of Src homology 2 domain-containing phosphatase 1 (SHP-1) to lipid rafts in T lymphocytes: functional implications and a role for the SHP-1 carboxyl terminus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Substrate-trapping techniques in the identification of cellular PTP targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Activated proliferation of B-cell lymphomas/leukemias with the SHP1 gene silencing by aberrant CpG methylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Phosphatases in cell-matrix adhesion and migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Gbeta gamma -independent constitutive association of Galpha s with SHP-1 and angiotensin II receptor AT2 is essential in AT2-mediated ITIM-independent activation of SHP-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Angiotensin II subtype 2 receptor activation inhibits insulin-induced phosphoinositide 3-kinase and Akt and induces apoptosis in PC12W cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Phosphotyrosine-binding domains in signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Src homology region 2 (SH2) domain-containing phosphatase-1 dephosphorylates B cell linker protein/SH2 domain leukocyte protein of 65 kDa and selectively regulates c-Jun NH2-terminal kinase activation in B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Inhibition of growth and metastatic progression of pancreatic carcinoma in hamster after somatostatin receptor subtype 2 (sst2) gene expression and administration of cytotoxic somatostatin analog AN-238.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

SHP-1 regulation of p62(DOK) tyrosine phosphorylation in macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Functional interaction between SHPTP1 and the Lyn tyrosine kinase in the apoptotic response to DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases using PTP-PEST as a model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Phosphotyrosine 1173 mediates binding of the protein-tyrosine phosphatase SHP-1 to the epidermal growth factor receptor and attenuation of receptor signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Hematopoietic cell phosphatase, SHP-1, is constitutively associated with the SH2 domain-containing leukocyte protein, SLP-76, in B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

The stress response to ionizing radiation involoves c-Abl-dependent phosphorylation of SHPTP1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: a new function for Src homology 2 domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Neither arginine nor histidine can carry out the function of lysine-295 in the ATP-binding site of p60src

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Tyr527 is phosphorylated in pp60c-src: implications for regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3173146

20 June 2018

Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.275685

21 January 2018

Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.275685

21 January 2018

RNA interference targeting SHP-1 attenuates myocardial infarction in rats

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.275685

21 January 2018

Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.275685

21 January 2018

Shp-2 mediates v-Src-induced morphological changes and activation of the anti-apoptotic protein kinase Akt.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.275685

21 January 2018

SHP-2 regulates the phosphatidylinositide 3'-kinase/Akt pathway and suppresses caspase 3-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.275685

21 January 2018

Human Protein Tyrosine Phosphatase 1C (PTPN6) Gene Structure: Alternate Promoter Usage and Exon Skipping Generate Multiple Transcripts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.275685

21 January 2018

Effective dephosphorylation of Src substrates by SHP-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.275685

21 January 2018

How DISC1 regulates postnatal brain development: girdin gets in on the AKT.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.275685

21 January 2018

The actin-binding protein Girdin and its Akt-mediated phosphorylation regulate neointima formation after vascular injury.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.275685

21 January 2018

Increased insulin-stimulated Akt pSer473 and cytosolic SHP2 protein abundance in human skeletal muscle following acute exercise and short-term training

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.275685

21 January 2018

Deficiency of Src homology 2-containing phosphatase 1 results in abnormalities in murine neutrophil function: studies in motheaten mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21799016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Both SH2 domains are involved in interaction of SHP-1 with the epidermal growth factor receptor but cannot confer receptor-directed activity to SHP-1/SHP-2 chimera

1 reference

https://pubmed.ncbi.nlm.nih.gov/21799016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SHP-1 associates with both platelet-derived growth factor receptor and the p85 subunit of phosphatidylinositol 3-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/21799016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conserved residues amino-terminal of cytoplasmic tyrosines contribute to the SHP-1-mediated inhibitory function of killer cell Ig-like receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21799016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/21799016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21799016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of SHP-1 tyrosine phosphatase expression correlates with the advanced stages of cutaneous T-cell lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21799016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.275685

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 September 2017

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