(Q30479736)

12 October 2017

Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution (English)

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12 October 2017

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inferred from abstract

fitness landscape

1 reference

https://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-2-17#article-info

25 October 2022

binding site

object named as

Substrate Binding Pocket

1 reference

https://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-2-17#article-info

25 October 2022

Neutral network

1 reference

https://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-2-17#article-info

25 October 2022

genetic drift

object named as

Neutral Evolution

1 reference

https://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-2-17#article-info

25 October 2022

enzyme promiscuity

object named as

promiscuous protein functions

1 reference

inferred from abstract

adaptive evolution

1 reference

inferred from abstract

author

Jesse D. Bloom

series ordinal

1

1 reference

12 October 2017

4

Frances H Arnold

1 reference

12 October 2017

Philip A Romero

2

1 reference

12 October 2017

Zhongyi Lu

3

1 reference

12 October 2017

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28 June 2007

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12 October 2017

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12 October 2017

2

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12 October 2017

17

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Creative Commons Attribution 2.0 Generic

12 October 2017

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describes a project that uses

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https://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-2-17#Sec14

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exact match

https://scigraph.springernature.com/pub.10.1186/1745-6150-2-17

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cites work

Evolution favors protein mutational robustness in sufficiently large populations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Multivariate-activity mining for molecular quasi-species in a glutathione transferase mutant library

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Beyond cataloging the Library of Babel.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Empirical fitness landscapes reveal accessible evolutionary paths

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Thermodynamics of neutral protein evolution

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

The Latent Promiscuity of Newly Identified Microbial Lactonases Is Linked to a Recently Diverged Phosphotriesterase†

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Relative tolerance of mesostable and thermostable protein homologs to extensive mutation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Enzyme promiscuity: evolutionary and mechanistic aspects.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Evolution of hormone-receptor complexity by molecular exploitation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Protein stability promotes evolvability

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Cytochromes P450 as versatile biocatalysts

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Catalytic promiscuity and the divergent evolution of DNA repair enzymes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Diversification and specialization of HIV protease function during in vitro evolution

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Missense meanderings in sequence space: a biophysical view of protein evolution

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Engineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Thermodynamic prediction of protein neutrality

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

The 'evolvability' of promiscuous protein functions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Divergence of function in the thioredoxin fold suprafamily: evidence for evolution of peroxiredoxins from a thioredoxin-like ancestor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Structural aspects of ligand binding to and electron transfer in bacterial and fungal P450s

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Functional evolution and structural conservation in chimeric cytochromes p450: calibrating a structure-guided approach

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

A self-sufficient peroxide-driven hydroxylation biocatalyst

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Evolution of the protein repertoire

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Enzymes with extra talents: moonlighting functions and catalytic promiscuity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Dobzhansky-Muller incompatibilities in protein evolution

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

P450 BM3: the very model of a modern flavocytochrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Engineering cytochrome P450 BM-3 for oxidation of polycyclic aromatic hydrocarbons

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Pivotal role of water in the mechanism of P450BM-3

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Rational evolution of a medium chain-specific cytochrome P-450 BM-3 variant.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Metastable evolutionary dynamics: crossing fitness barriers or escaping via neutral paths?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Catalytic promiscuity and the evolution of new enzymatic activities

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Smoothness within ruggedness: the role of neutrality in adaptation.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Deleterious mutations, apparent stabilizing selection and the maintenance of quantitative variation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Is the evolution of insulin Darwinian or due to selectively neutral mutation?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Latent evolutionary potentials under the neutral mutational drift of an enzyme

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Preparation of human metabolites of propranolol using laboratory-evolved bacterial cytochromes P450.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Shared promiscuous activities and evolutionary features in various members of the amidohydrolase superfamily.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Direct conversion of ethane to ethanol by engineered cytochrome P450 BM3.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Regio- and enantioselective alkane hydroxylation with engineered cytochromes P450 BM-3.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

High-throughput screen for aromatic hydroxylation

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

High-throughput carbon monoxide binding assay for cytochromes p450.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Exploring phenotype space through neutral evolution.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Step-wise mutation of barnase to binase. A procedure for engineering increased stability of proteins and an experimental analysis of the evolution of protein stability

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Molecular recognition in cytochrome P-450: mechanism for the control of uncoupling reactions.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1914045

Continuity in evolution: on the nature of transitions

26 November 2018

1 reference

12 December 2020

In search of the limits of evolution

1 reference

12 December 2020

The catalytic mechanism of cytochrome P450 BM3 involves a 6 Å movement of the bound substrate on reduction

1 reference

12 December 2020

Are branched chain fatty acids the natural substrates for P450(BM3)?

1 reference

12 December 2020

Modelling neutral and selective evolution of protein folding

1 reference

12 December 2020

A continuous spectrophotometric assay for P450 BM-3, a fatty acid hydroxylating enzyme, and its mutant F87A

1 reference

12 December 2020

In vivo activation of zoxazolamine metabolism by flavone

1 reference

12 December 2020

Why are proteins marginally stable?

1 reference

12 December 2020

Evolutionary Divergence and Convergence in Proteins

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1186/1745-6150-2-17

Finite populations induce metastability in evolutionary search

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1186/1745-6150-2-17

Identifiers

DOI

10.1186/1745-6150-2-17

1 reference

Dimensions Publication ID

12 October 2017

1 reference

0 references

1 reference

12 October 2017

1 reference

PMCID

1914045