(Q30487092)

18 August 2017

T cell receptor-dependent tyrosine phosphorylation of beta2-chimaerin modulates its Rac-GAP function in T cells (English)

1 reference

18 August 2017

1 reference

Isabel Mérida

2

1 reference

ORCID Public Data File 2021

author name string

María Siliceo

series ordinal

1

1 reference

PMCID

2670141

18 August 2017

language of work or name

English

0 references

publication date

6 February 2009

1 reference

Journal of Biological Chemistry

18 August 2017

1 reference

18 August 2017

284

1 reference

18 August 2017

17

1 reference

18 August 2017

11354-11363

1 reference

PMCID

2670141

describes a project that uses

18 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2670141/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Alpha2-chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse

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20 June 2018

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Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling

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20 June 2018

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Regulation of T-cell activation by the cytoskeleton

20 June 2018

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A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells

20 June 2018

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Phospholipase Cgamma/diacylglycerol-dependent activation of beta2-chimaerin restricts EGF-induced Rac signaling

20 June 2018

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20 June 2018

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Essential role for Rac in heregulin beta1 mitogenic signaling: a mechanism that involves epidermal growth factor receptor and is independent of ErbB4.

20 June 2018

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Beta2-chimaerin provides a diacylglycerol-dependent mechanism for regulation of adhesion and chemotaxis of T cells

20 June 2018

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Vav-family proteins in T-cell signalling

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20 June 2018

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GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

20 June 2018

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Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin

20 June 2018

1 reference

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Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

20 June 2018

1 reference

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Interplay between TCR signalling and actin cytoskeleton dynamics.

20 June 2018

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Diacylglycerol-dependent binding recruits PKCtheta and RasGRP1 C1 domains to specific subcellular localizations in living T lymphocytes.

20 June 2018

1 reference

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Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src.

20 June 2018

1 reference

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Rho GTPase-activating proteins in cell regulation

20 June 2018

1 reference

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Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

alpha2-chimaerin, a Cdc42/Rac1 regulator, is selectively expressed in the rat embryonic nervous system and is involved in neuritogenesis in N1E-115 neuroblastoma cells.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

Differential clustering of CD4 and CD3zeta during T cell recognition

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

The Wiskott-Aldrich syndrome protein-interacting protein (WIP) binds to the adaptor protein Nck

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

Lck regulates Vav activation of members of the Rho family of GTPases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

Interaction of the Nck adapter protein with p21-activated kinase (PAK1)

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

20 June 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

20 June 2018

https://api.crossref.org/works/10.1074%2FJBC.M806098200

The GTPase-activating protein n-chimaerin cooperates with Rac1 and Cdc42Hs to induce the formation of lamellipodia and filopodia

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

Multiple p21ras effector pathways regulate nuclear factor of activated T cells.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

The aminosteroid U-73122 inhibits muscarinic receptor sequestration and phosphoinositide hydrolysis in SK-N-SH neuroblastoma cells. A role for Gp in receptor compartmentation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

20 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806098200

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806098200

Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806098200

Tyrosine phosphorylation of beta2-chimaerin by Src-family kinase negatively regulates its Rac-specific GAP activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806098200

Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806098200

SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806098200

Pharmacology of the receptors for the phorbol ester tumor promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M806098200

Expression of a catalytically inactive form of diacylglycerol kinase alpha induces sustained signaling through RasGRP.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2670141

EphA4-dependent axon guidance is mediated by the RacGAP alpha2-chimaerin

26 November 2018

1 reference

12 December 2020

The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation

1 reference

12 December 2020

TCR and CD28 are coupled via ZAP-70 to the activation of the Vav/Rac-1-/PAK-1/p38 MAPK signaling pathway

1 reference

12 December 2020

The lipid second messenger diacylglycerol as a negative regulator of Rac signalling

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M806098200

1 reference

18 August 2017

1 reference

18 August 2017

1 reference

PMCID

2670141