(Q30757280)

17 August 2017

Transthyretin variants with improved inhibition of β-amyloid aggregation (English)

1 reference

17 August 2017

Parth Mangrolia

1

1 reference

PMCID

4867095

17 August 2017

Dennis T Yang

series ordinal

2

1 reference

PMCID

4867095

17 August 2017

Regina M Murphy

series ordinal

3

1 reference

17 August 2017

19 April 2016

1 reference

Protein Engineering Design and Selection

17 August 2017

1 reference

17 August 2017

29

1 reference

17 August 2017

6

1 reference

17 August 2017

209-218

1 reference

PMCID

4867095

describes a project that uses

17 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4867095/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Evaluation of Nanoparticle Tracking for Characterization of Fibrillar Protein Aggregates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Delineation of concentration ranges and longitudinal changes of human plasma protein variants

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Transthyretin-derived peptides as β-amyloid inhibitors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Distinct transthyretin oxidation isoform profile in spinal fluid from patients with Alzheimer's disease and mild cognitive impairment

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Mechanisms of transthyretin inhibition of β-amyloid aggregation in vitro

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

News from the protein mutability landscape

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Transthyretin as both a sensor and a scavenger of β-amyloid oligomers

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Identification of beta-amyloid-binding sites on transthyretin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Experimentally derived structural constraints for amyloid fibrils of wild-type transthyretin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Familial amyloid polyneuropathy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Neuronal production of transthyretin in human and murine Alzheimer's disease: is it protective?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Mass spectrometric immunoassay for quantitative determination of transthyretin and its variants

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

A partially folded structure of amyloid-beta(1-40) in an aqueous environment

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

The Japanese Mutant Aβ (ΔE22-Aβ1−39) Forms Fibrils Instantaneously, with Low-Thioflavin T Fluorescence: Seeding of Wild-Type Aβ1−40into Atypical Fibrils by ΔE22-Aβ1−39

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Characterization of the interaction of β-amyloid with transthyretin monomers and tetramers

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Critical evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the measurement of nanoparticles and protein aggregates

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Differential modification of Cys10 alters transthyretin's effect on beta-amyloid aggregation and toxicity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Structural insight into pH-induced conformational changes within the native human transthyretin tetramer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

The modulation of transthyretin tetramer stability by cysteine 10 adducts and the drug diflunisal. Direct analysis by fluorescence-detected analytical ultracentrifugation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Transthyretin binding to A-Beta peptide--impact on A-Beta fibrillogenesis and toxicity.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Extrinsic fluorescent dyes as tools for protein characterization

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Structural basis for the protective role of sulfite against transthyretin amyloid formation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Differential post-translational modifications of transthyretin in Alzheimer's disease: a study of the cerebral spinal fluid.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

The pathway by which the tetrameric protein transthyretin dissociates.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

L55P transthyretin accelerates subunit exchange and leads to rapid formation of hybrid tetramers.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Transthyretin inhibition of amyloid beta aggregation and toxicity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

The binding of thioflavin-T to amyloid fibrils: localisation and implications

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Transthyretin: a review from a structural perspective.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Support for the multigenic hypothesis of amyloidosis: the binding stoichiometry of retinol-binding protein, vitamin A, and thyroid hormone influences transthyretin amyloidogenicity in vitro

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Trans-suppression of misfolding in an amyloid disease.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

The x-ray crystal structure refinements of normal human transthyretin and the amyloidogenic Val-30-->Met variant to 1.7-A resolution

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Transthyretin sequesters amyloid beta protein and prevents amyloid formation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Fibril in senile systemic amyloidosis is derived from normal transthyretin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Analysis of thyroid hormone binding to human serum prealbumin by 8-anilinonaphthalene-1-sulfonate fluorescence

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin).

20 June 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZW008

Mutagenic analysis of the nucleation propensity of oxidized Alzheimer's beta-amyloid peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZW008

Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZW008

Characterization and stability of transthyretin isoforms in cerebrospinal fluid examined by immunoprecipitation and high-resolution mass spectrometry of intact protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZW008

Online registry for mutations in hereditary amyloidosis including nomenclature recommendations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZW008

Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZW008

Kinetic stabilization of an oligomeric protein under physiological conditions demonstrated by a lack of subunit exchange: implications for transthyretin amyloidosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZW008

Cys10 mixed disulfides make transthyretin more amyloidogenic under mildly acidic conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZW008

KFC2: a knowledge-based hot spot prediction method based on interface solvation, atomic density, and plasticity features.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZW008

The Tetrameric Protein Transthyretin Dissociates to a Non-native Monomer in Solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZW008

Transthyretin amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZW008

Detailed Structural Analysis of Amyloidogenic Wild-Type Transthyretin Using a Novel Purification Strategy and Mass Spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FPROTEIN%2FGZW008

Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4867095

Immunotherapy for Alzheimer's disease

25 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27099354

12 December 2020

inferred from PubMed ID database lookup

Quantifying the kinetic stability of hyperstable proteins via time-dependent SDS trapping

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27099354

12 December 2020

inferred from PubMed ID database lookup

X-ray analysis of thyroid hormone binding to prealbumin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27099354

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1093/PROTEIN/GZW008

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ntkcz27d4fhkbhjv2oz2bu3zgu

30 July 2022

release_ntkcz27d4fhkbhjv2oz2bu3zgu

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ntkcz27d4fhkbhjv2oz2bu3zgu

30 July 2022

https://api.fatcat.wiki/v0/release/ntkcz27d4fhkbhjv2oz2bu3zgu

1 reference

30 July 2022

https://api.fatcat.wiki/v0/release/ntkcz27d4fhkbhjv2oz2bu3zgu

1 reference

30 July 2022