(Q48499999)

English

Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways.

scientific article published in September 2002

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scholarly article

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Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/12196559

Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758007&resulttype=core&format=json

12 May 2020

1 reference

based on heuristic

inferred from title

neurodegeneration

1 reference

based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758007&resulttype=core&format=json

12 May 2020

author name string

Jeffrey A Johnson

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758007&resulttype=core&format=json

12 May 2020

language of work or name

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publication date

1 September 2002

1 reference

Europe PubMed Central

PubMed publication ID

12 February 2018

http://europepmc.org/abstract/MED/12196559

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758007&resulttype=core&format=json

12 May 2020

22

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758007&resulttype=core&format=json

12 May 2020

17

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758007&resulttype=core&format=json

12 May 2020

7380-7388

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758007&resulttype=core&format=json

12 May 2020

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of growth hormone receptor delivers an antiapoptotic signal: evidence for a role of Akt in this pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improvement of multiple pathophysiological phenotypes of klotho (kl/kl) mice by adenovirus-mediated expression of the klotho gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of EGFR-mediated phosphoinositide-3-OH kinase (PI3-K) signaling and glioblastoma phenotype by signal-regulatory proteins (SIRPs)

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-site APP cleaving enzyme mRNA expression in APP transgenic mice: anatomical overlap with transgene expression and static levels with aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor-1 (IGF-1): a neuroprotective trophic factor acting via the Akt kinase pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylated map kinase (ERK1, ERK2) expression is associated with early tau deposition in neurones and glial cells, but not with increased nuclear DNA vulnerability and cell death, in Alzheimer disease, Pick's disease, progressive supranuclear pa

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth hormone as a neuronal rescue factor during recovery from CNS injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of the Alzheimer amyloid fragment Abeta(25-35) on Akt/PKB kinase and survival of PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effect of sodium orthovanadate on delayed neuronal death after transient forebrain ischemia in gerbil hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma homocysteine as a risk factor for dementia and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coordinated pattern of expression and localization of insulin-like growth factor-II (IGF-II) and IGF-binding protein-2 in the adult rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of amyloid peptides beta-(1-40) and beta-(25-35) injections into the rat nucleus basalis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor-1 activation of extracellular signal-related kinase-1 and -2 in growth hormone-secreting cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transthyretin sequesters amyloid beta protein and prevents amyloid formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptosis by c-Fos protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prolactin activates tyrosyl phosphorylation of insulin receptor substrate 1 and phosphatidylinositol-3-OH kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrospinal fluid transthyretin: aging and late onset Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of amyloid precursor protein catabolism involves the mitogen-activated protein kinase signal transduction pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factors-I and -II differentially regulate endogenous acetylcholine release from the rat hippocampal formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-ordinated and cellular specific induction of the components of the IGF/IGFBP axis in the rat brain following hypoxic-ischemic injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuron loss in APP transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative neuronal c-fos and c-jun expression in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High density synthetic oligonucleotide arrays

1 reference

https://pubmed.ncbi.nlm.nih.gov/12196559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.22-17-07380.2002

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758007&resulttype=core&format=json

12 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758007&resulttype=core&format=json

12 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758007&resulttype=core&format=json

12 May 2020

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