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Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease
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scholarly article
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PubMed
title
Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease
(English)
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stated in
PubMed
main subject
pathogenesis
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based on heuristic
inferred from title
Alzheimer's disease
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based on heuristic
inferred from title
author
Eliezer Masliah
series ordinal
2
0 references
author name string
Cassia R. Overk
series ordinal
1
1 reference
stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
15 April 2014
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stated in
PubMed
published in
Biochemical Pharmacology
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stated in
PubMed
volume
88
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stated in
PubMed
issue
4
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stated in
PubMed
page(s)
508-16
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PubMed
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The genetics of Alzheimer disease
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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
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Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
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AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss
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A role for tau at the synapse in Alzheimer's disease pathogenesis.
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28 September 2017
Identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and Alzheimer's diseases
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28 September 2017
Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model
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28 September 2017
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28 September 2017
Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathies
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Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease
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28 September 2017
Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein.
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28 September 2017
Abnormal interaction of oligomeric amyloid-β with phosphorylated tau: implications to synaptic dysfunction and neuronal damage
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28 September 2017
Synaptic changes in the dentate gyrus of APP/PS1 transgenic mice revealed by electron microscopy
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28 September 2017
Synapse stability in the precuneus early in the progression of Alzheimer's disease
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Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia
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28 September 2017
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28 September 2017
Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease
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28 September 2017
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28 September 2017
Genetic insights in Alzheimer's disease
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28 September 2017
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28 September 2017
The central theme of Parkinson's disease: α-synuclein
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28 September 2017
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28 September 2017
Role of tau protein in neuronal damage in Alzheimer's disease and Down syndrome.
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28 September 2017
Pathogenesis of Abeta oligomers in synaptic failure.
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28 September 2017
Targeting synaptic dysfunction in Alzheimer's disease therapy.
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28 September 2017
Synaptotoxic amyloid-β oligomers: a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease?
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28 September 2017
Neurotoxicity of amyloid β-protein: synaptic and network dysfunction
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28 September 2017
Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease
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28 September 2017
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28 September 2017
Structural features and cytotoxicity of amyloid oligomers: implications in Alzheimer's disease and other diseases with amyloid deposits
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28 September 2017
α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer
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28 September 2017
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
Aggregation of αSynuclein promotes progressive in vivo neurotoxicity in adult rat dopaminergic neurons
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases
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28 September 2017
Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques
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28 September 2017
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28 September 2017
Semi-quantitative analysis of alpha-synuclein in subcellular pools of rat brain neurons: an immunogold electron microscopic study using a C-terminal specific monoclonal antibody
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28 September 2017
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28 September 2017
Alpha-synuclein alters Notch-1 expression and neurogenesis in mouse embryonic stem cells and in the hippocampus of transgenic mice.
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28 September 2017
Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization
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28 September 2017
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28 September 2017
Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.
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28 September 2017
A network dysfunction perspective on neurodegenerative diseases
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28 September 2017
Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery
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28 September 2017
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28 September 2017
Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence
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28 September 2017
Demonstration of a role for alpha-synuclein as a functional microtubule-associated protein
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28 September 2017
Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration
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28 September 2017
Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity
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28 September 2017
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice
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28 September 2017
Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model
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28 September 2017
Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?
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28 September 2017
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28 September 2017
Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry.
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28 September 2017
Delayed localization of synelfin (synuclein, NACP) to presynaptic terminals in cultured rat hippocampal neurons
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28 September 2017
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973539
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28 November 2018
Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the Consortium on DLB International Workshop.
1 reference
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PubMed Central
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28 November 2018
Collaborative Analysis of α-Synuclein Gene Promoter Variability and Parkinson Disease
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973539
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28 November 2018
Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers.
1 reference
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PubMed Central
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28 November 2018
Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973539
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28 November 2018
Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.
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PubMed Central
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28 November 2018
Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice.
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PubMed Central
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28 November 2018
Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973539
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28 November 2018
α-Synuclein Is Degraded by Both Autophagy and the Proteasome
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973539
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28 November 2018
Proteasome inhibition causes nigral degeneration with inclusion bodies in rats
1 reference
stated in
PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973539
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28 November 2018
Phases of A beta-deposition in the human brain and its relevance for the development of AD.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973539
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28 November 2018
Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973539
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28 November 2018
TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973539
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28 November 2018
Accumulation of alpha-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy.
1 reference
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PubMed Central
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28 November 2018
Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973539
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28 November 2018
Structural and kinetic features of amyloid beta-protein fibrillogenesis
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28 November 2018
Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3973539
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28 November 2018
Differing patterns of aberrant neuronal sprouting in Alzheimer's disease with and without Lewy bodies
1 reference
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28 November 2018
Quantitative assessment of synaptic density in the entorhinal cortex in Alzheimer's disease.
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PubMed Central
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28 November 2018
ADDLs & protofibrils--the missing links?
1 reference
stated in
PubMed
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https://pubmed.ncbi.nlm.nih.gov/24462903
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24462903
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.BCP.2014.01.015
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
526572
Fatcat ID
release_72d2dhanorepxdrl7thgnio6r4
0 references
OpenCitations bibliographic resource ID
526572
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
526572
PMC publication ID
3973539
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
526572
PubMed publication ID
24462903
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
526572
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