(Q37778899)

English

Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies

scientific article published on January 2010

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scholarly article

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Europe PubMed Central

PubMed publication ID

23 August 2017

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Europe PubMed Central

Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies (English)

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

0 references

Parkinson's disease

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

0 references

3

object named as

Hilal A Lashuel

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

author name string

Abid Oueslati

1

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

Margot Fournier

2

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

publication date

1 January 2010

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Europe PubMed Central

PubMed publication ID

23 August 2017

Progress in Brain Research

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

183

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

115-145

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Cellular polyamines promote the aggregation of alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

The dark side of EGFP: defective polyubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Paramagnetism-based NMR restraints provide maximum allowed probabilities for the different conformations of partially independent protein domains.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Interactions between metals and alpha-synuclein--function or artefact?

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Double-stranded DNA stimulates the fibrillation of alpha-synuclein in vitro and is associated with the mature fibrils: an electron microscopy study

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitin immunochemistry as a diagnostic aid for community pathologists evaluating patients who have dementia.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Heparin and other glycosaminoglycans stimulate the formation of amyloid fibrils from alpha-synuclein in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthetic filaments assembled from C-terminally truncated alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Aggregates from mutant and wild-type alpha-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of beta-sheet and amyloid-like filaments

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

A Drosophila model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

alpha-Synuclein is phosphorylated in synucleinopathy lesions

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Polycation-induced oligomerization and accelerated fibrillation of human alpha-synuclein in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

alpha-Synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostaining

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Parkin counteracts symptoms in a Drosophila model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Impact of the acidic C-terminal region comprising amino acids 109-140 on alpha-synuclein aggregation in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Cleavage of normal and pathological forms of alpha-synuclein by neurosin in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural and functional implications of C-terminal regions of alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Casein kinase II-mediated phosphorylation regulates alpha-synuclein/synphilin-1 interaction and inclusion body formation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Increased alpha-synuclein aggregation following limited cleavage by certain matrix metalloproteinases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Accelerated formation of alpha-synuclein oligomers by concerted action of the 20S proteasome and familial Parkinson mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Impaired dopamine storage resulting from alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitin is a common factor in intermediate filament inclusion bodies of diverse type in man, including those of Parkinson's disease, Pick's disease, and Alzheimer's disease, as well as Rosenthal fibres in cerebellar astrocytomas, cytoplasmic bodie

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitin is associated with abnormal cytoplasmic filaments characteristic of neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of synucleins by members of the Polo-like kinase family

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Alpha synuclein is present in Lewy bodies in sporadic Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of alpha-synuclein carboxy-terminus on fibril formation in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiple phosphorylation of alpha-synuclein by protein tyrosine kinase Syk prevents eosin-induced aggregation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitination of alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Localization of a novel type trypsin-like serine protease, neurosin, in brain tissues of Alzheimer's disease and Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Copper(II)-induced self-oligomerization of alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Prediction of "aggregation-prone" and "aggregation-susceptible" regions in proteins associated with neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural determinants of PLD2 inhibition by alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Synucleins are a novel class of substrates for G protein-coupled receptor kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Proteasomal inhibition-induced inclusion formation and death in cortical neurons require transcription and ubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of fibrillization and accumulation of prefibrillar oligomers in mixtures of human and mouse alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Monoubiquitylation of alpha-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

High transgene expression by lentiviral vectors causes maldevelopment of Purkinje cells in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Alpha-synuclein in Lewy bodies

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxidative stress-induced phosphorylation, degradation and aggregation of alpha-synuclein are linked to upregulated CK2 and cathepsin D

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Risk factors for dopaminergic neuron loss in human alpha-synuclein transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Neuropathology in mice expressing human alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of conformational and dynamic properties of natively unfolded human and mouse alpha-synuclein ensembles by NMR: implication for aggregation.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

alpha-synuclein degradation by autophagic pathways: a potential key to Parkinson's disease pathogenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Overexpression of alpha-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of alpha-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Nitration inhibits fibrillation of human α‐synuclein in vitro by formation of soluble oligomers

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0079-6123%2810%2983007-9

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0079-6123(10)83007-9

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 August 2017

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